SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i51'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1i51 CASPASE-7 SUBUNIT
P20
X-LINKED INHIBITOR
OF APOPTOSIS PROTEIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 TYR A 151
GLY E 144
THR E 143
MET A  84
GLY A 188
 None
 1.27A 1nbiC-1i51A:
2.1		 1nbiC-1i51A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1i51 CASPASE-7 SUBUNIT
P20
X-LINKED INHIBITOR
OF APOPTOSIS PROTEIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 TYR A 151
GLY E 144
THR E 143
MET A  84
GLY A 188
 None
 1.27A 1nbiD-1i51A:
2.2		 1nbiD-1i51A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1i51 CASPASE-7 SUBUNIT
P11
CASPASE-7 SUBUNIT
P20
(Homo
sapiens) 		5 / 9 PHE A 106
LEU B 299
LEU B 262
LEU B 249
PHE A 182
 None
 1.26A 2vcvH-1i51A:
undetectable		 2vcvH-1i51A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 1i51 CASPASE-7 SUBUNIT
P20
(Homo
sapiens) 		5 / 10 PHE A 182
ALA A  96
PHE A 101
PHE A 106
LEU A 104
 None
 1.33A 3a3yA-1i51A:
2.4		 3a3yA-1i51A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1i51 CASPASE-7 SUBUNIT
P20
CASPASE-7 SUBUNIT
P11
(Homo
sapiens;
Homo
sapiens) 		4 / 4 ASP A 193
GLY A 194
LYS B 285
GLU B 274
 None
 1.06A 3hznD-1i51A:
undetectable		 3hznD-1i51A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1i51 CASPASE-7 SUBUNIT
P11
CASPASE-7 SUBUNIT
P20
(Homo
sapiens) 		4 / 7 LEU A 191
TYR B 230
VAL B 265
ILE B 288
 None
 1.24A 3ik3A-1i51A:
undetectable		 3ik3A-1i51A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 1i51 CASPASE-7 SUBUNIT
P11
(Homo
sapiens) 		3 / 3 PRO B 289
PHE B 273
ALA B 244
 None
 0.72A 3itaD-1i51B:
undetectable		 3itaD-1i51B:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_2
(VITAMIN D3 RECEPTOR)		 1i51 CASPASE-7 SUBUNIT
P11
CASPASE-7 SUBUNIT
P20
(Homo
sapiens) 		5 / 9 LEU B 295
ARG B 264
TYR B 300
LEU A 104
VAL B 291
 None
 1.26A 3m7rA-1i51B:
0.4		 3m7rA-1i51B:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1i51 CASPASE-7 SUBUNIT
P20
CASPASE-7 SUBUNIT
P11
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ILE B 258
PHE A 101
PHE A 106
LEU A 104
 None
 0.78A 3v7pA-1i51B:
undetectable		 3v7pA-1i51B:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 1i51 CASPASE-7 SUBUNIT
P20
(Homo
sapiens) 		5 / 12 MET A 119
LEU A 123
ILE A 183
ILE A 150
LEU A 142
 None
 1.06A 4j24C-1i51A:
undetectable		 4j24C-1i51A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 1i51 CASPASE-7 SUBUNIT
P20
(Homo
sapiens) 		5 / 12 MET A 119
LEU A 123
ILE A 150
LEU A 162
LEU A 142
 None
 1.18A 4j24D-1i51A:
undetectable		 4j24D-1i51A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1i51 CASPASE-7 SUBUNIT
P20
(Homo
sapiens) 		5 / 12 MET A 119
LEU A 123
ILE A 183
ILE A 150
LEU A 142
 None
 1.05A 4j26B-1i51A:
undetectable		 4j26B-1i51A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 1i51 CASPASE-7 SUBUNIT
P11
CASPASE-7 SUBUNIT
P20
(Homo
sapiens) 		4 / 7 PRO B 227
GLU A 147
SER B 224
THR A  90
 None
 1.28A 4uacA-1i51B:
0.0		 4uacA-1i51B:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1i51 CASPASE-7 SUBUNIT
P20
(Homo
sapiens) 		4 / 7 VAL A 108
ILE A 109
LEU A 162
LEU A 123
 None
 0.91A 4xo7A-1i51A:
undetectable		 4xo7A-1i51A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1i51 CASPASE-7 SUBUNIT
P11
X-LINKED INHIBITOR
OF APOPTOSIS PROTEIN
(Homo
sapiens) 		3 / 3 THR B 225
HIS B 281
LEU E 141
 None
 0.87A 5axdC-1i51B:
undetectable		 5axdC-1i51B:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1i51 CASPASE-7 SUBUNIT
P20
(Homo
sapiens) 		3 / 3 ARG A 167
HIS A 165
ARG A 170
 None
 1.01A 5iaoC-1i51A:
undetectable		 5iaoC-1i51A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1i51 CASPASE-7 SUBUNIT
P20
(Homo
sapiens) 		3 / 3 ARG A 167
HIS A 165
ARG A 170
 None
 1.05A 5iaoF-1i51A:
undetectable		 5iaoF-1i51A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 1i51 X-LINKED INHIBITOR
OF APOPTOSIS PROTEIN
(Homo
sapiens) 		4 / 5 THR E 135
HIS E 136
ALA E 137
ASP E 138
 None
 1.39A 5mfxA-1i51E:
undetectable		 5mfxA-1i51E:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 1i51 CASPASE-7 SUBUNIT
P20
(Homo
sapiens) 		5 / 12 MET A 119
LEU A 123
ILE A 150
LEU A 162
LEU A 142
 None
 1.16A 5toaB-1i51A:
undetectable		 5toaB-1i51A:
21.90