SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		5 / 9 ASN A 409
ASP A 449
ARG A 452
ILE A 454
THR A 531
 MN  A 996 ( 2.8A)
ACP  A 998 (-3.7A)
None
ACP  A 998 (-4.3A)
ACP  A 998 (-3.8A)
 1.02A 1aj6A-1i5aA:
5.8		 1aj6A-1i5aA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		4 / 5 GLU A 390
THR A 389
HIS A 438
LEU A 539
 None
 0.99A 1d4fC-1i5aA:
undetectable		 1d4fC-1i5aA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		5 / 12 ASP A 412
ASP A 449
ARG A 452
ILE A 454
THR A 531
 None
ACP  A 998 (-3.7A)
None
ACP  A 998 (-4.3A)
ACP  A 998 (-3.8A)
 1.22A 1kijA-1i5aA:
5.8		 1kijA-1i5aA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		5 / 12 ASN A 409
ASP A 449
ARG A 452
ILE A 454
THR A 531
 MN  A 996 ( 2.8A)
ACP  A 998 (-3.7A)
None
ACP  A 998 (-4.3A)
ACP  A 998 (-3.8A)
 0.94A 1kijB-1i5aA:
5.7		 1kijB-1i5aA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		4 / 7 PHE A 362
ALA A 436
ILE A 399
ILE A 535
 None
 0.98A 1oniD-1i5aA:
undetectable
1oniF-1i5aA:
undetectable		 1oniD-1i5aA:
24.74
1oniF-1i5aA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		3 / 3 LEU A 403
PRO A 402
LEU A 406
 None
 0.57A 2po5B-1i5aA:
undetectable		 2po5B-1i5aA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		3 / 3 GLY A 414
GLY A 530
GLY A 451
 ACP  A 998 (-3.4A)
None
None
 0.34A 3bogC-1i5aA:
0.0		 3bogC-1i5aA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		3 / 3 GLY A 414
GLY A 530
GLY A 451
 ACP  A 998 (-3.4A)
None
None
 0.39A 3bogD-1i5aA:
undetectable		 3bogD-1i5aA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		3 / 3 VAL A 514
VAL A 533
SER A 522
 None
 0.72A 3n8xB-1i5aA:
undetectable		 3n8xB-1i5aA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		4 / 6 LYS A 511
ILE A 521
VAL A 533
LEU A 406
 None
 1.11A 4em2A-1i5aA:
undetectable		 4em2A-1i5aA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		4 / 8 PHE A 485
ILE A 460
PHE A 491
GLY A 467
 None
 0.96A 4fgjA-1i5aA:
undetectable
4fgjB-1i5aA:
undetectable		 4fgjA-1i5aA:
21.46
4fgjB-1i5aA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		5 / 12 GLY A 414
ALA A 410
GLY A 451
LEU A 432
GLY A 530
 ACP  A 998 (-3.4A)
ACP  A 998 (-4.1A)
None
None
None
 0.92A 4o3fA-1i5aA:
undetectable		 4o3fA-1i5aA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		5 / 12 ASN A 409
ASP A 449
ARG A 452
ILE A 454
THR A 531
 MN  A 996 ( 2.8A)
ACP  A 998 (-3.7A)
None
ACP  A 998 (-4.3A)
ACP  A 998 (-3.8A)
 1.07A 4uroD-1i5aA:
5.5		 4uroD-1i5aA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		5 / 12 LEU A 406
ILE A 454
VAL A 488
PHE A 487
MET A 507
 None
ACP  A 998 (-4.3A)
None
None
ACP  A 998 (-3.7A)
 1.15A 4y0pA-1i5aA:
0.0		 4y0pA-1i5aA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		5 / 12 VAL A 533
ILE A 454
VAL A 488
PHE A 487
MET A 507
 None
ACP  A 998 (-4.3A)
None
None
ACP  A 998 (-3.7A)
 0.96A 4y0pA-1i5aA:
0.0		 4y0pA-1i5aA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		5 / 12 SER A 520
GLU A 515
VAL A 514
SER A 492
GLY A 490
 None
None
None
ACP  A 998 ( 3.7A)
None
 1.31A 5f9zB-1i5aA:
undetectable		 5f9zB-1i5aA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 1i5a CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		5 / 12 GLY A 430
GLY A 414
GLY A 451
GLU A 448
ALA A 410
 None
ACP  A 998 (-3.4A)
None
None
ACP  A 998 (-4.1A)
 1.20A 5x7fA-1i5aA:
undetectable		 5x7fA-1i5aA:
25.00