SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i5e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		5 / 12 ILE A  77
LEU A 118
PRO A 119
LEU A 147
ILE A 100
 None
 0.89A 1df7A-1i5eA:
undetectable		 1df7A-1i5eA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		4 / 6 PHE A 127
ILE A 100
LYS A 148
ALA A 152
 None
 1.26A 1hk2A-1i5eA:
0.7		 1hk2A-1i5eA:
16.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		5 / 5 MET A 133
ALA A 135
TYR A 193
ILE A 194
ASP A 200
 U5P  A 250 (-4.7A)
U5P  A 250 (-3.2A)
U5P  A 250 (-4.5A)
U5P  A 250 (-4.4A)
U5P  A 250 (-4.4A)
 0.62A 1upfA-1i5eA:
27.6		 1upfA-1i5eA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		4 / 7 ALA A 135
TYR A 193
ILE A 194
ASP A 200
 U5P  A 250 (-3.2A)
U5P  A 250 (-4.5A)
U5P  A 250 (-4.4A)
U5P  A 250 (-4.4A)
 0.35A 1upfB-1i5eA:
27.7		 1upfB-1i5eA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		4 / 7 MET A 133
ALA A 135
TYR A 193
ILE A 194
 U5P  A 250 (-4.7A)
U5P  A 250 (-3.2A)
U5P  A 250 (-4.5A)
U5P  A 250 (-4.4A)
 0.59A 1upfB-1i5eA:
27.7		 1upfB-1i5eA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		5 / 5 MET A 133
ALA A 135
TYR A 193
ILE A 194
ASP A 200
 U5P  A 250 (-4.7A)
U5P  A 250 (-3.2A)
U5P  A 250 (-4.5A)
U5P  A 250 (-4.4A)
U5P  A 250 (-4.4A)
 0.58A 1upfC-1i5eA:
27.8		 1upfC-1i5eA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		4 / 4 MET A 133
ALA A 135
TYR A 193
ILE A 194
 U5P  A 250 (-4.7A)
U5P  A 250 (-3.2A)
U5P  A 250 (-4.5A)
U5P  A 250 (-4.4A)
 0.52A 1upfD-1i5eA:
28.4		 1upfD-1i5eA:
36.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		4 / 5 LEU A 118
GLY A  98
HIS A  99
ILE A 100
 None
 0.87A 1xf1A-1i5eA:
undetectable		 1xf1A-1i5eA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		4 / 6 LEU A 118
GLY A  98
HIS A  99
ILE A 100
 None
 0.87A 1xf1B-1i5eA:
2.3		 1xf1B-1i5eA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		5 / 12 GLY A  81
GLY A  83
ARG A  79
HIS A  99
ILE A 100
 None
 1.15A 4krhB-1i5eA:
3.4		 4krhB-1i5eA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		5 / 12 ILE A  77
LEU A 118
PRO A 119
LEU A 147
ILE A 100
 None
 0.97A 4m2xA-1i5eA:
undetectable		 4m2xA-1i5eA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		5 / 12 ILE A  77
LEU A 118
PRO A 119
LEU A 147
ILE A 100
 None
 0.99A 4m2xC-1i5eA:
undetectable		 4m2xC-1i5eA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		5 / 12 ILE A  77
LEU A 118
PRO A 119
LEU A 147
ILE A 100
 None
 0.95A 4m2xE-1i5eA:
undetectable		 4m2xE-1i5eA:
21.80