SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i5g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 1i5g TRYPAREDOXIN II
(Crithidia
fasciculata) 		4 / 5 LEU A   4
GLU A 117
ALA A  28
LEU A  24
 None
 1.20A 1eta1-1i5gA:
undetectable		 1eta1-1i5gA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 1i5g TRYPAREDOXIN II
(Crithidia
fasciculata) 		4 / 6 LEU A   4
GLU A 117
ALA A  28
LEU A  24
 None
 1.16A 1etb1-1i5gA:
0.0		 1etb1-1i5gA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1i5g TRYPAREDOXIN II
(Crithidia
fasciculata) 		5 / 12 PHE A   8
VAL A 116
PHE A  34
ALA A  28
ALA A 118
 None
 1.24A 1q23A-1i5gA:
undetectable
1q23B-1i5gA:
undetectable		 1q23A-1i5gA:
21.23
1q23B-1i5gA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1i5g TRYPAREDOXIN II
(Crithidia
fasciculata) 		5 / 12 ALA A  19
ASP A  21
LEU A  27
LEU A  88
TYR A  82
 None
 1.04A 3k2hA-1i5gA:
undetectable		 3k2hA-1i5gA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 1i5g TRYPAREDOXIN II
(Crithidia
fasciculata) 		5 / 11 SER A  44
ILE A 110
ILE A  69
LEU A  68
ASP A  72
 None
TS5  A 401 (-4.1A)
None
None
None
 1.09A 4dt8A-1i5gA:
undetectable		 4dt8A-1i5gA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1i5g TRYPAREDOXIN II
(Crithidia
fasciculata) 		3 / 3 GLY A  29
THR A  31
ASN A  63
 None
 0.68A 5odiG-1i5gA:
1.4		 5odiG-1i5gA:
13.21