SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i5p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		3 / 3 GLU A 254
ILE A 258
ARG A 548
 None
 0.67A 1cd2A-1i5pA:
undetectable		 1cd2A-1i5pA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		5 / 12 MET A  90
GLY A  85
GLN A 179
MET A 183
LEU A  77
 None
 1.13A 1p93C-1i5pA:
0.3		 1p93C-1i5pA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		5 / 10 LEU A 117
ALA A 180
VAL A 113
LEU A 173
PHE A  82
 None
 1.25A 1rlbE-1i5pA:
undetectable		 1rlbE-1i5pA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 8 ASN A 416
SER A 397
ARG A 405
ALA A 277
 None
 0.99A 1rqpC-1i5pA:
undetectable		 1rqpC-1i5pA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 8 ASN A 416
SER A 397
ARG A 405
ALA A 277
 None
 1.03A 1rqpA-1i5pA:
undetectable		 1rqpA-1i5pA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		5 / 12 LEU A 173
LEU A 176
ALA A 180
LEU A 120
ILE A 166
 None
 1.02A 1s9pD-1i5pA:
2.2		 1s9pD-1i5pA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 7 TYR A 255
THR A  97
VAL A  57
MET A 183
 None
 1.03A 1tv8A-1i5pA:
undetectable		 1tv8A-1i5pA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		3 / 3 ILE A 146
ASP A 190
PHE A 187
 None
 0.44A 1uwjB-1i5pA:
1.3		 1uwjB-1i5pA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		5 / 12 ILE A 258
ARG A 470
LEU A  77
ILE A  80
PHE A 262
 None
 1.28A 1y0xX-1i5pA:
0.9		 1y0xX-1i5pA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 8 TYR A 255
THR A  97
VAL A  57
MET A 183
 None
 1.12A 2fb2A-1i5pA:
undetectable		 2fb2A-1i5pA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 7 TYR A 255
THR A  97
VAL A  57
MET A 183
 None
 1.17A 2fb2B-1i5pA:
undetectable		 2fb2B-1i5pA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 7 ASN A 336
LEU A 316
SER A 334
THR A 332
 None
 1.02A 2uz2A-1i5pA:
undetectable		 2uz2A-1i5pA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 8 ASN A 416
SER A 397
ARG A 405
ALA A 277
 None
 1.00A 2v7uA-1i5pA:
undetectable		 2v7uA-1i5pA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 8 ILE A 188
TYR A 208
GLN A 154
PHE A 157
 None
 0.98A 2weyB-1i5pA:
4.5		 2weyB-1i5pA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 5 TYR A 475
ILE A 484
LEU A 369
LEU A   5
 None
 1.16A 2zb7A-1i5pA:
undetectable		 2zb7A-1i5pA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 7 ILE A 622
PHE A 624
ARG A 533
THR A 560
 None
 1.17A 2zxwN-1i5pA:
3.6
2zxwW-1i5pA:
0.0		 2zxwN-1i5pA:
23.40
2zxwW-1i5pA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 6 VAL A 269
SER A 260
LEU A 193
LEU A 267
 None
 0.82A 3kk6A-1i5pA:
0.0		 3kk6A-1i5pA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 6 VAL A 269
SER A 260
LEU A 193
LEU A 267
 None
 0.88A 3kk6B-1i5pA:
undetectable		 3kk6B-1i5pA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		3 / 3 GLY A 540
GLY A 538
THR A 601
 None
 0.43A 3si7B-1i5pA:
undetectable		 3si7B-1i5pA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 5 PHE A 494
TYR A 491
ILE A 258
LEU A  62
 None
 1.34A 3sueC-1i5pA:
0.0		 3sueC-1i5pA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 6 GLY A 352
HIS A 358
SER A 337
THR A 354
 None
 1.11A 3tj7A-1i5pA:
0.0
3tj7B-1i5pA:
0.0		 3tj7A-1i5pA:
14.46
3tj7B-1i5pA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 6 GLY A 352
HIS A 358
SER A 337
THR A 354
 None
 1.13A 3tj7C-1i5pA:
0.0
3tj7D-1i5pA:
0.0		 3tj7C-1i5pA:
14.46
3tj7D-1i5pA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 6 HIS A 358
SER A 337
THR A 354
GLY A 352
 None
 1.13A 3tj7C-1i5pA:
0.0
3tj7D-1i5pA:
0.0		 3tj7C-1i5pA:
14.46
3tj7D-1i5pA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		3 / 3 ASP A 618
ARG A 524
ASP A 521
 None
 0.81A 4fp9D-1i5pA:
undetectable		 4fp9D-1i5pA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		3 / 3 SER A 329
ALA A 388
VAL A 387
 None
 0.63A 4o2bA-1i5pA:
undetectable		 4o2bA-1i5pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		3 / 3 SER A 329
ALA A 388
VAL A 387
 None
 0.64A 4o2bC-1i5pA:
undetectable		 4o2bC-1i5pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 7 GLU A  98
THR A  97
LEU A 117
ASN A 114
 None
 1.15A 4pfjA-1i5pA:
undetectable		 4pfjA-1i5pA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 8 HIS A  46
SER A 376
ARG A 375
TRP A 393
 None
 0.92A 4uhxA-1i5pA:
undetectable		 4uhxA-1i5pA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 5 LEU A 173
GLU A  98
MET A  90
LEU A 117
 None
 1.37A 4xi3B-1i5pA:
1.2		 4xi3B-1i5pA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		3 / 3 ALA A 273
ASN A 274
LEU A 275
 None
 0.49A 5i1pD-1i5pA:
undetectable		 5i1pD-1i5pA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		3 / 3 HIS A 500
SER A 304
ARG A 424
 None
 0.98A 5u63A-1i5pA:
undetectable		 5u63A-1i5pA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 6 ASN A   3
ALA A 476
VAL A   4
TYR A 475
 None
 1.22A 5umd2-1i5pA:
0.0
5umdF-1i5pA:
0.0		 5umd2-1i5pA:
7.89
5umdF-1i5pA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 7 THR A 246
ARG A 245
PHE A 244
LEU A 101
 None
 1.12A 5uxcA-1i5pA:
2.1		 5uxcA-1i5pA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 7 ILE A 423
ARG A 405
THR A 395
LEU A 378
 None
 0.93A 5xdxA-1i5pA:
2.9
5xdxJ-1i5pA:
undetectable		 5xdxA-1i5pA:
23.40
5xdxJ-1i5pA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		4 / 5 ILE A 622
PHE A 624
ARG A 533
THR A 560
 None
 1.29A 5z84N-1i5pA:
3.0
5z84W-1i5pA:
0.0		 5z84N-1i5pA:
23.40
5z84W-1i5pA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		3 / 3 ASP A 618
ARG A 524
ASP A 521
 None
 0.84A 5zvgA-1i5pA:
undetectable		 5zvgA-1i5pA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		3 / 3 ASP A 618
ARG A 524
ASP A 521
 None
 0.82A 5zvgB-1i5pA:
undetectable		 5zvgB-1i5pA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		6 / 12 LEU A 120
LEU A 161
ILE A  93
GLU A 116
VAL A 113
LEU A 117
 None
 1.43A 6ecxA-1i5pA:
undetectable		 6ecxA-1i5pA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA
(Bacillus
thuringiensis) 		3 / 3 LEU A  62
ASN A 274
LEU A 250
 None
 0.55A 6exiA-1i5pA:
undetectable		 6exiA-1i5pA:
8.15