SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i6a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1i6a HYDROGEN
PEROXIDE-INDUCIBLE
GENES ACTIVATOR
(Escherichia
coli) 		5 / 10 ILE A  98
THR A 129
ASP A 196
THR A 100
ILE A 268
 None
 1.38A 3kpbD-1i6aA:
undetectable		 3kpbD-1i6aA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1i6a HYDROGEN
PEROXIDE-INDUCIBLE
GENES ACTIVATOR
(Escherichia
coli) 		4 / 8 GLY A 102
LEU A  97
ILE A  98
ILE A 268
 None
 0.69A 4em2A-1i6aA:
undetectable		 4em2A-1i6aA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 1i6a HYDROGEN
PEROXIDE-INDUCIBLE
GENES ACTIVATOR
(Escherichia
coli) 		6 / 12 LEU A  93
LEU A 124
LEU A 113
MET A 112
ILE A 145
ILE A 289
 None
 1.49A 4o2bB-1i6aA:
undetectable		 4o2bB-1i6aA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 1i6a HYDROGEN
PEROXIDE-INDUCIBLE
GENES ACTIVATOR
(Escherichia
coli) 		5 / 12 VAL A 231
ILE A 237
LEU A 257
TYR A 256
LEU A 240
 None
 1.05A 4pd4C-1i6aA:
undetectable		 4pd4C-1i6aA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1i6a HYDROGEN
PEROXIDE-INDUCIBLE
GENES ACTIVATOR
(Escherichia
coli) 		4 / 6 LEU A 105
TYR A 104
PRO A 107
GLU A 126
 None
 1.25A 4z4gA-1i6aA:
undetectable		 4z4gA-1i6aA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 1i6a HYDROGEN
PEROXIDE-INDUCIBLE
GENES ACTIVATOR
(Escherichia
coli) 		4 / 7 ILE A 268
ARG A 266
VAL A 101
ILE A  98
 None
 1.00A 4zzbC-1i6aA:
undetectable
4zzbD-1i6aA:
undetectable		 4zzbC-1i6aA:
23.03
4zzbD-1i6aA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1i6a HYDROGEN
PEROXIDE-INDUCIBLE
GENES ACTIVATOR
(Escherichia
coli) 		4 / 7 LEU A 224
THR A 100
PRO A 241
LEU A 146
 None
 1.04A 5fxtA-1i6aA:
undetectable		 5fxtA-1i6aA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 1i6a HYDROGEN
PEROXIDE-INDUCIBLE
GENES ACTIVATOR
(Escherichia
coli) 		5 / 10 LEU A 120
ILE A 110
LEU A 124
ALA A 143
LEU A 270
 None
 1.24A 5y7pG-1i6aA:
undetectable		 5y7pG-1i6aA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1i6a HYDROGEN
PEROXIDE-INDUCIBLE
GENES ACTIVATOR
(Escherichia
coli) 		4 / 4 GLY A 269
LEU A 148
VAL A 271
GLU A 157
 None
 1.45A 5yw0A-1i6aA:
0.0		 5yw0A-1i6aA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		 1i6a HYDROGEN
PEROXIDE-INDUCIBLE
GENES ACTIVATOR
(Escherichia
coli) 		5 / 11 ILE A  98
LEU A 243
PRO A 107
ILE A 109
MET A 293
 None
 1.42A 6fgdA-1i6aA:
undetectable		 6fgdA-1i6aA:
18.75