SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i6q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 12 TYR A 400
LEU A 680
HIS A 246
LEU A 407
ILE A 381
 None
 1.38A 1fmlA-1i6qA:
0.0		 1fmlA-1i6qA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		3 / 3 GLU A  80
HIS A 253
ASP A 302
 None
 0.83A 1i9gA-1i6qA:
undetectable		 1i9gA-1i6qA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 12 THR A 326
GLY A 387
GLU A 333
SER A 322
ARG A 342
 None
 1.48A 1jdvE-1i6qA:
undetectable
1jdvF-1i6qA:
undetectable		 1jdvE-1i6qA:
16.19
1jdvF-1i6qA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 12 LEU A 434
LEU A 589
PHE A 487
LEU A 571
HIS A 458
 None
 1.27A 1kt5A-1i6qA:
undetectable		 1kt5A-1i6qA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		4 / 8 ASP A  66
TYR A 324
LEU A 320
GLY A  68
 None
 0.89A 1rmtC-1i6qA:
undetectable		 1rmtC-1i6qA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 10 LEU A 298
ASP A 302
SER A 291
TRP A   8
THR A  10
 None
 1.50A 1rqpC-1i6qA:
1.1		 1rqpC-1i6qA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 12 GLY A 472
PHE A 475
ALA A 668
TYR A 665
ARG A 674
 None
 1.40A 2avdA-1i6qA:
undetectable		 2avdA-1i6qA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		4 / 8 ALA A 529
PHE A 530
ALA A 534
LEU A 564
 None
 0.94A 2bxmA-1i6qA:
0.0		 2bxmA-1i6qA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		3 / 3 LYS A 151
GLY A 140
PRO A 141
 None
 0.93A 2hreB-1i6qA:
0.0		 2hreB-1i6qA:
19.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		3 / 3 LEU A 651
TYR A 660
GLY A 662
 None
 0.40A 2ocuA-1i6qA:
25.8		 2ocuA-1i6qA:
42.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		4 / 5 SER A 316
GLY A  68
HIS A 253
ASP A  66
 None
 1.02A 2oxtB-1i6qA:
undetectable		 2oxtB-1i6qA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		4 / 6 VAL A  95
GLY A 406
ARG A 600
LEU A 385
 None
 1.09A 3bjwE-1i6qA:
undetectable		 3bjwE-1i6qA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 10 LEU A 407
ALA A 382
ILE A 314
GLY A 317
ILE A 325
 None
 1.07A 3el5A-1i6qA:
undetectable		 3el5A-1i6qA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 12 ALA A 389
VAL A 597
PHE A 641
VAL A 410
LEU A 611
 None
 1.30A 3hkuA-1i6qA:
undetectable		 3hkuA-1i6qA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 12 VAL A 384
LEU A 385
ILE A 401
GLY A 403
ALA A 402
 None
 1.12A 3kk6A-1i6qA:
0.0		 3kk6A-1i6qA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		4 / 7 LEU A 611
VAL A 597
LEU A 407
ASP A 390
 None
 0.95A 3rgfA-1i6qA:
0.0		 3rgfA-1i6qA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		4 / 5 LEU A 533
PHE A 530
PHE A 569
ARG A 440
 None
 1.05A 3smtA-1i6qA:
0.0		 3smtA-1i6qA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 12 GLY A 321
ILE A 401
GLY A 406
ALA A 683
SER A 678
 None
 0.92A 3sudB-1i6qA:
undetectable		 3sudB-1i6qA:
15.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 7 GLY A 432
PRO A 593
ASN A 594
TYR A 660
GLY A 662
 None
 0.60A 3tajA-1i6qA:
25.5		 3tajA-1i6qA:
42.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 11 LEU A 230
THR A 235
LEU A 132
PHE A 152
PHE A 135
 None
 1.37A 3tbgA-1i6qA:
0.0		 3tbgA-1i6qA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 12 GLY A 525
GLY A 466
HIS A 458
ARG A 522
GLU A 510
 None
 1.34A 3tkaA-1i6qA:
undetectable		 3tkaA-1i6qA:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		4 / 5 GLY A 432
PRO A 593
ASN A 594
TYR A 660
 None
 0.61A 3u8qA-1i6qA:
27.2		 3u8qA-1i6qA:
55.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		3 / 3 GLN A 200
PHE A 196
TYR A 227
 None
 0.92A 3ucjB-1i6qA:
undetectable		 3ucjB-1i6qA:
16.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		4 / 6 GLY A 432
PRO A 593
GLY A 662
TYR A 665
 None
 0.58A 4dxuA-1i6qA:
27.4		 4dxuA-1i6qA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		4 / 6 GLY A 432
VAL A 591
PRO A 593
TYR A 665
 None
 0.88A 4dxuA-1i6qA:
27.4		 4dxuA-1i6qA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 9 GLY A 432
PRO A 593
TYR A 660
GLY A 662
TYR A 665
 None
 0.63A 4fimA-1i6qA:
27.0		 4fimA-1i6qA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 9 PRO A 593
GLU A 659
TYR A 660
GLY A 662
TYR A 665
 None
 0.92A 4fimA-1i6qA:
27.0		 4fimA-1i6qA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 6 GLY A 432
PRO A 593
ASN A 594
TYR A 660
GLY A 662
 None
 0.65A 4fjpA-1i6qA:
27.4		 4fjpA-1i6qA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 7 GLY A 432
PRO A 593
ASN A 594
TYR A 660
GLY A 662
 None
 0.55A 4forA-1i6qA:
26.1		 4forA-1i6qA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		3 / 3 PRO A 251
TYR A 319
GLY A 321
 None
 0.59A 4g2zA-1i6qA:
27.2		 4g2zA-1i6qA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		3 / 3 PRO A 593
TYR A 660
GLY A 662
 None
 0.36A 4g2zA-1i6qA:
27.2		 4g2zA-1i6qA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		4 / 7 ILE A 127
LEU A 131
HIS A 246
ALA A 248
 None
 0.58A 4g77A-1i6qA:
25.8		 4g77A-1i6qA:
42.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 8 GLY A 406
VAL A 598
ALA A 596
ASP A 658
LEU A 661
 None
 1.06A 4l9iB-1i6qA:
undetectable		 4l9iB-1i6qA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		3 / 3 SER A 122
ASP A 302
ASP A  60
 CO3  A 692 (-4.1A)
None
None
 0.77A 4uckA-1i6qA:
undetectable		 4uckA-1i6qA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		4 / 6 LEU A 230
LEU A 229
GLU A 228
ILE A  97
 None
 0.78A 4ww7A-1i6qA:
0.0		 4ww7A-1i6qA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		3 / 3 ASP A  66
GLY A  62
ASP A  60
 None
 0.60A 4xdtA-1i6qA:
0.0		 4xdtA-1i6qA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		6 / 12 ASP A 395
LEU A 680
ARG A 673
ILE A 401
VAL A 384
LEU A 392
 None
 1.38A 4y8wA-1i6qA:
undetectable		 4y8wA-1i6qA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		5 / 12 ASP A 395
LEU A 680
ILE A 401
VAL A 384
LEU A 392
 None
 0.99A 4y8wB-1i6qA:
undetectable		 4y8wB-1i6qA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		4 / 7 SER A 122
GLY A  61
GLY A  62
ILE A 328
 CO3  A 692 (-4.1A)
None
None
None
 0.62A 4yjiA-1i6qA:
0.0		 4yjiA-1i6qA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		3 / 3 ASP A 395
GLU A 354
SER A 676
 None
 0.81A 5bw4B-1i6qA:
undetectable		 5bw4B-1i6qA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		4 / 4 LEU A 266
ARG A 309
ILE A 267
ILE A  77
 None
 1.23A 5dzk2-1i6qA:
undetectable
5dzkM-1i6qA:
undetectable
5dzkN-1i6qA:
0.0		 5dzk2-1i6qA:
1.52
5dzkM-1i6qA:
15.03
5dzkN-1i6qA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1i6q LACTOFERRIN
(Camelus
dromedarius) 		3 / 3 ALA A 148
VAL A 161
TYR A 166
 None
 0.71A 5zmqH-1i6qA:
undetectable		 5zmqH-1i6qA:
13.78