SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		5 / 10 LEU A 265
ALA A 217
ASP A 203
VAL A 219
ILE A 202
 None
None
MG  A 403 ( 4.3A)
None
None
 1.19A 1d4sA-1i74A:
undetectable		 1d4sA-1i74A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_B_TOYB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		5 / 9 ASP A  12
GLU A  44
ALA A 292
THR A 255
ASP A 203
 MN  A 401 ( 2.0A)
None
None
None
MG  A 403 ( 4.3A)
 1.48A 1m4dB-1i74A:
1.2		 1m4dB-1i74A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		4 / 5 LEU A  38
ALA A  15
ILE A  16
SER A  19
 None
MN  A 401 ( 4.1A)
None
None
 0.86A 2othA-1i74A:
undetectable		 2othA-1i74A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		4 / 5 HIS A  97
HIS A  98
ASP A 149
ASP A  12
 MN  A 402 ( 3.6A)
SO4  A 405 (-3.8A)
MN  A 402 ( 2.6A)
MN  A 401 ( 2.0A)
 1.08A 3c0zA-1i74A:
undetectable		 3c0zA-1i74A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		4 / 5 HIS A  98
ASP A  75
HIS A  97
ASP A  14
 SO4  A 405 (-3.8A)
MN  A 401 (-2.5A)
MN  A 402 ( 3.6A)
MN  A 402 (-3.3A)
 1.23A 3c0zA-1i74A:
undetectable		 3c0zA-1i74A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		4 / 6 HIS A  97
HIS A  98
ASP A 149
ASP A  12
 MN  A 402 ( 3.6A)
SO4  A 405 (-3.8A)
MN  A 402 ( 2.6A)
MN  A 401 ( 2.0A)
 1.10A 3c0zC-1i74A:
undetectable		 3c0zC-1i74A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		4 / 8 ASN A 130
GLU A  93
TYR A  22
LEU A  25
 None
 1.05A 3rqwC-1i74A:
undetectable
3rqwD-1i74A:
undetectable		 3rqwC-1i74A:
24.38
3rqwD-1i74A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		4 / 8 GLU A  93
TYR A  22
LEU A  25
ASN A 130
 None
 1.07A 3rqwF-1i74A:
undetectable
3rqwJ-1i74A:
undetectable		 3rqwF-1i74A:
24.38
3rqwJ-1i74A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		4 / 7 LEU A 146
ASP A 162
GLU A 114
HIS A  97
 None
None
None
MN  A 402 ( 3.6A)
 1.09A 4aq7A-1i74A:
2.4		 4aq7A-1i74A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		5 / 12 ALA A  68
VAL A  71
GLN A   9
ILE A  86
PHE A   6
 None
 1.11A 4c49A-1i74A:
undetectable		 4c49A-1i74A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		5 / 12 ASP A 162
GLY A 117
ALA A 119
GLY A 145
ASP A  14
 None
None
MN  A 402 ( 4.9A)
None
MN  A 402 (-3.3A)
 0.88A 4dc3A-1i74A:
undetectable		 4dc3A-1i74A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		4 / 7 LEU A  38
ALA A  15
ASP A  14
ILE A 138
 None
MN  A 401 ( 4.1A)
MN  A 402 (-3.3A)
None
 0.81A 4eyrA-1i74A:
undetectable		 4eyrA-1i74A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		4 / 6 VAL A 227
LEU A 228
ARG A 230
LEU A 252
 None
 0.95A 4o1zA-1i74A:
0.0		 4o1zA-1i74A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		3 / 3 ASP A 149
ASP A  75
ASN A  77
 MN  A 402 ( 2.6A)
MN  A 401 (-2.5A)
None
 0.84A 4q5mA-1i74A:
undetectable		 4q5mA-1i74A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		5 / 12 TYR A 180
LEU A 153
ALA A 166
ILE A  16
SER A 121
 None
 1.09A 5hbsA-1i74A:
undetectable		 5hbsA-1i74A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		4 / 6 ASP A  96
HIS A  97
HIS A  98
HIS A   8
 None
MN  A 402 ( 3.6A)
SO4  A 405 (-3.8A)
MN  A 401 ( 3.5A)
 0.92A 5ncdA-1i74A:
undetectable
5ncdD-1i74A:
undetectable		 5ncdA-1i74A:
23.42
5ncdD-1i74A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		4 / 6 HIS A   8
ASP A  96
HIS A  97
HIS A  98
 MN  A 401 ( 3.5A)
None
MN  A 402 ( 3.6A)
SO4  A 405 (-3.8A)
 0.90A 5ncdB-1i74A:
undetectable
5ncdC-1i74A:
undetectable		 5ncdB-1i74A:
23.42
5ncdC-1i74A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		5 / 12 PRO A  11
GLY A   7
ASP A 203
ILE A 202
ASP A  14
 None
None
MG  A 403 ( 4.3A)
None
MN  A 402 (-3.3A)
 1.26A 5wwsB-1i74A:
undetectable		 5wwsB-1i74A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
mutans) 		3 / 3 LYS A 273
ASN A 270
SER A 212
 None
 0.94A 5yw0A-1i74A:
0.0		 5yw0A-1i74A:
23.26