SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i78'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 1i78 PROTEASE VII
(Escherichia
coli) 		4 / 7 ILE A 219
ASP A 214
ASN A 269
ASP A 267
 None
 0.91A 1yc5A-1i78A:
undetectable		 1yc5A-1i78A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 1i78 PROTEASE VII
(Escherichia
coli) 		4 / 8 TYR A 180
ASP A 113
TRP A  71
TYR A 230
 None
 1.25A 2ha2B-1i78A:
undetectable		 2ha2B-1i78A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1i78 PROTEASE VII
(Escherichia
coli) 		5 / 12 LEU A 120
GLY A 129
GLY A 185
SER A 186
ASN A 122
 None
 1.13A 3cjtG-1i78A:
undetectable		 3cjtG-1i78A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 1i78 PROTEASE VII
(Escherichia
coli) 		3 / 3 PRO A  62
SER A   6
ASN A  11
 None
 0.73A 3lslG-1i78A:
0.0		 3lslG-1i78A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1i78 PROTEASE VII
(Escherichia
coli) 		5 / 12 SER A 137
GLN A 105
THR A 142
SER A  76
PHE A 141
 None
None
None
BOG  A 900 (-2.8A)
None
 1.31A 4c49D-1i78A:
undetectable		 4c49D-1i78A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1i78 PROTEASE VII
(Escherichia
coli) 		3 / 3 ARG A 218
HIS A 268
TYR A 213
 None
 1.07A 4fu8A-1i78A:
undetectable		 4fu8A-1i78A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1i78 PROTEASE VII
(Escherichia
coli) 		3 / 3 ARG A 218
HIS A 268
TYR A 213
 None
 1.03A 4fu9A-1i78A:
0.0		 4fu9A-1i78A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 1i78 PROTEASE VII
(Escherichia
coli) 		5 / 12 GLY A  54
GLY A  70
ILE A  56
ALA A  68
ALA A  14
 None
 1.03A 4kicA-1i78A:
undetectable		 4kicA-1i78A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 1i78 PROTEASE VII
(Escherichia
coli) 		5 / 12 GLY A  54
GLY A  70
ILE A  56
ALA A  68
ALA A  14
 None
 1.06A 4kicB-1i78A:
undetectable		 4kicB-1i78A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1i78 PROTEASE VII
(Escherichia
coli) 		5 / 9 PHE A 163
GLY A 166
ARG A 144
ALA A 169
GLY A 146
 None
 1.24A 5l8rA-1i78A:
undetectable		 5l8rA-1i78A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1i78 PROTEASE VII
(Escherichia
coli) 		4 / 6 PHE A  46
LEU A 106
ALA A  49
ASN A 254
 None
 0.95A 6f88A-1i78A:
undetectable		 6f88A-1i78A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 1i78 PROTEASE VII
(Escherichia
coli) 		5 / 12 THR A 184
GLY A 185
LEU A 128
GLY A  67
ASN A 122
 None
 1.19A 6gngA-1i78A:
undetectable		 6gngA-1i78A:
18.75