SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1i7k UBIQUITIN-CONJUGATIN
G ENZYME E2 H10
(Homo
sapiens) 		5 / 12 GLY A  64
SER A  51
VAL A 128
LEU A 132
LEU A  83
 None
 0.84A 1mx1D-1i7kA:
undetectable		 1mx1D-1i7kA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 1i7k UBIQUITIN-CONJUGATIN
G ENZYME E2 H10
(Homo
sapiens) 		5 / 10 LEU A 132
LEU A  83
ALA A  52
LEU A  35
LEU A  42
 None
 1.02A 4p65A-1i7kA:
undetectable
4p65B-1i7kA:
undetectable
4p65F-1i7kA:
undetectable
4p65H-1i7kA:
undetectable		 4p65A-1i7kA:
8.06
4p65B-1i7kA:
9.47
4p65F-1i7kA:
9.47
4p65H-1i7kA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 1i7k UBIQUITIN-CONJUGATIN
G ENZYME E2 H10
(Homo
sapiens) 		5 / 11 LEU A 132
LEU A  83
ALA A  52
LEU A  42
LEU A  35
 None
 0.97A 4p65C-1i7kA:
undetectable
4p65D-1i7kA:
undetectable
4p65J-1i7kA:
undetectable
4p65L-1i7kA:
undetectable		 4p65C-1i7kA:
8.06
4p65D-1i7kA:
9.47
4p65J-1i7kA:
9.47
4p65L-1i7kA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 1i7k UBIQUITIN-CONJUGATIN
G ENZYME E2 H10
(Homo
sapiens) 		5 / 11 LEU A 132
LEU A  83
ALA A  52
LEU A  35
LEU A  42
 None
 0.93A 4p65E-1i7kA:
undetectable
4p65F-1i7kA:
undetectable
4p65J-1i7kA:
undetectable
4p65L-1i7kA:
undetectable		 4p65E-1i7kA:
8.06
4p65F-1i7kA:
9.47
4p65J-1i7kA:
9.47
4p65L-1i7kA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 1i7k UBIQUITIN-CONJUGATIN
G ENZYME E2 H10
(Homo
sapiens) 		5 / 12 LEU A  35
LEU A  42
LEU A 132
LEU A  83
ALA A  52
 None
 1.01A 4p65B-1i7kA:
undetectable
4p65D-1i7kA:
undetectable
4p65I-1i7kA:
undetectable
4p65J-1i7kA:
undetectable		 4p65B-1i7kA:
9.47
4p65D-1i7kA:
9.47
4p65I-1i7kA:
8.06
4p65J-1i7kA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1i7k UBIQUITIN-CONJUGATIN
G ENZYME E2 H10
(Homo
sapiens) 		3 / 3 TYR A  79
THR A  65
THR A 100
 None
 0.70A 5aoxB-1i7kA:
0.4		 5aoxB-1i7kA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1i7k UBIQUITIN-CONJUGATIN
G ENZYME E2 H10
(Homo
sapiens) 		3 / 3 TYR A  79
THR A  65
THR A 100
 None
 0.75A 5aoxE-1i7kA:
0.3		 5aoxE-1i7kA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 1i7k UBIQUITIN-CONJUGATIN
G ENZYME E2 H10
(Homo
sapiens) 		4 / 5 LEU A  81
LEU A 118
PHE A  98
LEU A 138
 None
 1.03A 5gtrA-1i7kA:
0.0		 5gtrA-1i7kA:
22.65