SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1i7n SYNAPSIN II
(Rattus
norvegicus) 		5 / 8 ALA A 375
ASP A 383
ILE A 248
ILE A 309
GLY A 334
 None
 1.24A 1sh9A-1i7nA:
undetectable		 1sh9A-1i7nA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1i7n SYNAPSIN II
(Rattus
norvegicus) 		5 / 12 MET A 415
LEU A 117
ILE A 407
PHE A 131
ILE A 142
 None
 1.11A 1xotA-1i7nA:
undetectable		 1xotA-1i7nA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 1i7n SYNAPSIN II
(Rattus
norvegicus) 		4 / 5 VAL A 203
LEU A 217
ILE A 220
VAL A 120
 None
 0.95A 4a9kB-1i7nA:
undetectable		 4a9kB-1i7nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1i7n SYNAPSIN II
(Rattus
norvegicus) 		4 / 6 HIS A 275
SER A 392
GLU A 387
ASP A 314
 None
 1.38A 4blvA-1i7nA:
undetectable		 4blvA-1i7nA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 1i7n SYNAPSIN II
(Rattus
norvegicus) 		4 / 7 VAL A 144
MET A 415
VAL A 411
THR A 408
 None
 0.90A 5e4dA-1i7nA:
0.0
5e4dB-1i7nA:
undetectable		 5e4dA-1i7nA:
21.41
5e4dB-1i7nA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1i7n SYNAPSIN II
(Rattus
norvegicus) 		4 / 8 ILE A 315
VAL A 388
ARG A 316
ASP A 403
 None
 0.98A 6hu9a-1i7nA:
undetectable
6hu9e-1i7nA:
undetectable		 6hu9a-1i7nA:
18.72
6hu9e-1i7nA:
16.28