SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		4 / 8 ASP A 177
ASP A  81
PRO A 170
THR A 171
 None
CA  A 190 (-3.1A)
None
None
 0.80A 3el9A-1i8aA:
undetectable		 3el9A-1i8aA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		4 / 8 ASP A 177
GLY A 182
PRO A 170
THR A 171
 None
 0.84A 3el9A-1i8aA:
undetectable		 3el9A-1i8aA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		5 / 9 VAL A  76
ILE A 128
ALA A  56
GLU A 130
ALA A 119
 None
None
None
CA  A 191 (-2.2A)
None
 1.14A 3mdvA-1i8aA:
0.0		 3mdvA-1i8aA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		5 / 12 ILE A 164
ASP A  74
LEU A  63
ASN A  64
ASN A  38
 None
CA  A 192 (-2.3A)
None
None
None
 1.22A 3q87B-1i8aA:
undetectable		 3q87B-1i8aA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		5 / 12 LEU A  52
LEU A 184
ASN A 183
ILE A 150
ILE A  25
 None
 1.08A 3ut5B-1i8aA:
undetectable		 3ut5B-1i8aA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		5 / 12 ASP A  12
ALA A 119
ASN A 103
ILE A  18
ASP A  16
 CA  A 191 (-3.0A)
None
None
None
CA  A 191 (-2.8A)
 1.26A 3w37A-1i8aA:
undetectable		 3w37A-1i8aA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		5 / 12 ASP A  12
ALA A 119
ASN A 103
ILE A  18
ASP A  16
 CA  A 191 (-3.0A)
None
None
None
CA  A 191 (-2.8A)
 1.24A 3welA-1i8aA:
2.1		 3welA-1i8aA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		5 / 11 ASP A 177
GLY A  88
ASP A  94
PRO A 170
THR A 171
 None
None
CA  A 190 (-2.3A)
None
None
 1.02A 4njvB-1i8aA:
undetectable		 4njvB-1i8aA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		5 / 12 LEU A  52
LEU A 184
ASN A 183
ILE A 150
ILE A  25
 None
 0.99A 4o2bB-1i8aA:
undetectable		 4o2bB-1i8aA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		5 / 12 LEU A  52
LEU A 184
ASN A 183
ILE A 150
ILE A  25
 None
 0.95A 4o2bD-1i8aA:
undetectable		 4o2bD-1i8aA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		5 / 11 ALA A  39
THR A  40
ALA A  41
GLY A 125
GLY A 126
 None
 0.74A 5lf3K-1i8aA:
undetectable
5lf3L-1i8aA:
undetectable		 5lf3K-1i8aA:
21.92
5lf3L-1i8aA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		5 / 11 ALA A  39
THR A  40
ALA A  41
GLY A 125
GLY A 126
 None
 0.74A 5lf3Y-1i8aA:
undetectable
5lf3Z-1i8aA:
undetectable		 5lf3Y-1i8aA:
21.92
5lf3Z-1i8aA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		5 / 12 LEU A  52
LEU A 184
ASN A 183
ILE A 150
ILE A  25
 None
 1.01A 5mioB-1i8aA:
undetectable		 5mioB-1i8aA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		4 / 5 ALA A 131
VAL A  54
PHE A 116
ILE A 150
 None
 1.00A 5of1A-1i8aA:
1.1		 5of1A-1i8aA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		4 / 5 ALA A 131
VAL A  54
PHE A 116
ILE A 150
 None
 1.02A 5of1B-1i8aA:
1.1		 5of1B-1i8aA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		5 / 12 LEU A  52
LEU A 184
ASN A 183
ILE A 150
ILE A  25
 None
 0.98A 5xiwB-1i8aA:
undetectable		 5xiwB-1i8aA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		5 / 12 GLY A  88
THR A 109
GLY A 108
ASP A 169
ASN A 173
 None
None
BGC  A 189 ( 4.3A)
None
None
 1.04A 6gngA-1i8aA:
undetectable		 6gngA-1i8aA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		5 / 11 ALA A  39
THR A  40
ALA A  41
GLY A 125
GLY A 126
 None
 0.74A 6hwdK-1i8aA:
undetectable
6hwdL-1i8aA:
undetectable		 6hwdK-1i8aA:
19.76
6hwdL-1i8aA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1i8a ENDO-1,4-BETA-XYLANA
SE A
(Thermotoga
maritima) 		5 / 11 ALA A  39
THR A  40
ALA A  41
GLY A 125
GLY A 126
 None
 0.74A 6hwdY-1i8aA:
undetectable
6hwdZ-1i8aA:
undetectable		 6hwdY-1i8aA:
19.76
6hwdZ-1i8aA:
21.02