SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.05A 1cqeA-1i8dA:
0.0		 1cqeA-1i8dA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.04A 1cqeB-1i8dA:
0.0		 1cqeB-1i8dA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 10 ALA A  88
ASP A  92
ILE A  94
GLY A   4
PRO A 186
 None
 1.13A 1d4sA-1i8dA:
undetectable		 1d4sA-1i8dA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.00A 1eqhA-1i8dA:
undetectable		 1eqhA-1i8dA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.03A 1eqhB-1i8dA:
undetectable		 1eqhB-1i8dA:
15.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  49
LEU A  63
ILE A  70
THR A  71
PHE A   2
 None
 0.96A 1i18A-1i8dA:
13.2
1i18B-1i8dA:
12.7		 1i18A-1i8dA:
100.00
1i18B-1i8dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 10 PHE A   2
LEU A  49
LEU A  63
ILE A  70
THR A  71
 None
 0.98A 1i18A-1i8dA:
13.2
1i18B-1i8dA:
12.7		 1i18A-1i8dA:
100.00
1i18B-1i8dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A 147
THR A 148
THR A 165
THR A 169
ILE A   5
VAL A   6
 None
 0.53A 1pkvA-1i8dA:
18.1
1pkvB-1i8dA:
18.0		 1pkvA-1i8dA:
100.00
1pkvB-1i8dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		9 / 11 SER A  41
CYH A  47
CYH A  48
LEU A  49
THR A  50
MET A  64
THR A  67
ILE A  70
THR A  71
 None
 0.53A 1pkvA-1i8dA:
18.1
1pkvB-1i8dA:
18.0		 1pkvA-1i8dA:
100.00
1pkvB-1i8dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		6 / 11 ILE A   5
VAL A   6
LEU A 147
THR A 148
THR A 165
THR A 169
 None
 0.48A 1pkvA-1i8dA:
18.1
1pkvB-1i8dA:
18.0		 1pkvA-1i8dA:
100.00
1pkvB-1i8dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		9 / 11 SER A  41
CYH A  47
CYH A  48
LEU A  49
THR A  50
MET A  64
THR A  67
ILE A  70
THR A  71
 None
 0.58A 1pkvA-1i8dA:
18.1
1pkvB-1i8dA:
18.0		 1pkvA-1i8dA:
100.00
1pkvB-1i8dA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 8 ALA A  88
ASP A  92
ILE A  94
GLY A   4
PRO A 186
 None
 1.14A 1sh9A-1i8dA:
undetectable		 1sh9A-1i8dA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		3 / 3 ASP A  62
ILE A  54
VAL A  84
 None
 0.64A 2avvD-1i8dA:
undetectable		 2avvD-1i8dA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.01A 2aylA-1i8dA:
0.0		 2aylA-1i8dA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.03A 2aylB-1i8dA:
0.0		 2aylB-1i8dA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		3 / 3 SER A  14
GLU A  53
ASP A  16
 None
 0.69A 2zthA-1i8dA:
undetectable		 2zthA-1i8dA:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 CYH A  47
LEU A  49
THR A  50
THR A  71
ILE A 103
 None
 0.36A 3a35A-1i8dA:
25.8		 3a35A-1i8dA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 CYH A  47
LEU A  49
THR A  50
THR A  71
ILE A 103
 None
 0.36A 3a35B-1i8dA:
26.1		 3a35B-1i8dA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 CYH A  47
LEU A  49
THR A  50
THR A  71
ILE A 103
 None
 0.39A 3a3bA-1i8dA:
25.0		 3a3bA-1i8dA:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 ASN A  72
PHE A 123
LEU A 171
THR A 169
THR A 170
 None
 1.08A 3bl1A-1i8dA:
undetectable		 3bl1A-1i8dA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		3 / 3 SER A  14
GLU A  53
ASP A  16
 None
 0.72A 3bwmA-1i8dA:
undetectable		 3bwmA-1i8dA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		3 / 3 SER A  14
GLU A  53
ASP A  16
 None
 0.75A 3bwyA-1i8dA:
undetectable		 3bwyA-1i8dA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A   4
GLY A  96
ILE A 145
ASN A  83
LEU A  98
 None
 1.17A 3ckkA-1i8dA:
undetectable		 3ckkA-1i8dA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 THR A 170
GLY A 172
ILE A 145
GLY A 144
LEU A 166
 None
 1.12A 3eeyA-1i8dA:
undetectable		 3eeyA-1i8dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 THR A 170
GLY A 172
ILE A 145
GLY A 144
LEU A 166
 None
 1.11A 3eeyB-1i8dA:
undetectable		 3eeyB-1i8dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 THR A 170
GLY A 172
ILE A 145
GLY A 144
LEU A 166
 None
 1.12A 3eeyC-1i8dA:
undetectable		 3eeyC-1i8dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 THR A 170
GLY A 172
ILE A 145
GLY A 144
LEU A 166
 None
 1.13A 3eeyD-1i8dA:
undetectable		 3eeyD-1i8dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 THR A 170
GLY A 172
ILE A 145
GLY A 144
LEU A 166
 None
 1.16A 3eeyE-1i8dA:
undetectable		 3eeyE-1i8dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 THR A 170
GLY A 172
ILE A 145
GLY A 144
LEU A 166
 None
 1.16A 3eeyJ-1i8dA:
undetectable		 3eeyJ-1i8dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A   4
GLY A  96
ILE A 145
LEU A  98
MET A  99
 None
 1.09A 3fzgA-1i8dA:
undetectable		 3fzgA-1i8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.07A 3ln1B-1i8dA:
undetectable		 3ln1B-1i8dA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.07A 3ln1C-1i8dA:
undetectable		 3ln1C-1i8dA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.08A 3ln1D-1i8dA:
0.0		 3ln1D-1i8dA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.00A 3n8wA-1i8dA:
0.0		 3n8wA-1i8dA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.01A 3n8zA-1i8dA:
0.0		 3n8zA-1i8dA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 0.98A 3nt1A-1i8dA:
0.0		 3nt1A-1i8dA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 0.98A 3nt1B-1i8dA:
undetectable		 3nt1B-1i8dA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.05A 3pghD-1i8dA:
undetectable		 3pghD-1i8dA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.07A 3rr3A-1i8dA:
undetectable		 3rr3A-1i8dA:
15.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 11 LEU A 147
THR A 148
GLU A 164
THR A 169
VAL A   6
 None
 0.56A 4e0fA-1i8dA:
28.7		 4e0fA-1i8dA:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		6 / 11 SER A  41
CYH A  48
LEU A  49
THR A  50
GLU A  66
THR A  71
 None
 0.66A 4e0fA-1i8dA:
28.7		 4e0fA-1i8dA:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		3 / 3 LYS A 137
THR A 148
ILE A 162
 None
 0.34A 4e0fB-1i8dA:
29.8		 4e0fB-1i8dA:
36.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 10 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.02A 4ph9A-1i8dA:
undetectable		 4ph9A-1i8dA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 10 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.01A 4ph9B-1i8dA:
undetectable		 4ph9B-1i8dA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 9 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 0.99A 4rs0A-1i8dA:
undetectable		 4rs0A-1i8dA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		3 / 3 SER A  14
GLU A  53
ASP A  16
 None
 0.72A 4xudA-1i8dA:
undetectable		 4xudA-1i8dA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 ASP A 143
ASN A 181
HIS A  44
VAL A  82
LEU A  76
 None
 1.41A 4yhaA-1i8dA:
undetectable		 4yhaA-1i8dA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.11A 5ikrB-1i8dA:
0.0		 5ikrB-1i8dA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.05A 5jvzA-1i8dA:
undetectable		 5jvzA-1i8dA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.07A 5jvzB-1i8dA:
0.0		 5jvzB-1i8dA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.04A 5jw1A-1i8dA:
undetectable		 5jw1A-1i8dA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 9 ALA A  88
ASP A  92
ILE A  94
GLY A   4
PRO A 186
 None
 1.20A 5kr2A-1i8dA:
undetectable		 5kr2A-1i8dA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1i8d RIBOFLAVIN SYNTHASE
(Escherichia
coli) 		5 / 8 GLY A  46
VAL A 180
ILE A 145
GLY A   4
ILE A 134
 None
 1.26A 5vkqB-1i8dA:
undetectable
5vkqC-1i8dA:
undetectable		 5vkqB-1i8dA:
8.97
5vkqC-1i8dA:
8.97