SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
HEAVY CHAIN
(Mus
musculus) 		4 / 8 GLN B 306
VAL B 416
GLY B 308
GLY B 309
 None
 0.74A 1ekjE-1i8kB:
0.0
1ekjF-1i8kB:
0.0		 1ekjE-1i8kB:
19.27
1ekjF-1i8kB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
LIGHT CHAIN
EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
HEAVY CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 4 THR A  25
LEU A   4
LEU B 345
GLN B 339
 None
 1.25A 1fbmA-1i8kA:
undetectable		 1fbmA-1i8kA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8H_A_H4BA902_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
LIGHT CHAIN
(Mus
musculus) 		4 / 5 SER A  49
MET A  33
ILE A  48
TRP A  35
 None
 1.47A 1m8hA-1i8kA:
0.0		 1m8hA-1i8kA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8H_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
LIGHT CHAIN
(Mus
musculus) 		4 / 5 SER A  49
MET A  33
ILE A  48
TRP A  35
 None
 1.50A 1m8hB-1i8kA:
0.0		 1m8hB-1i8kA:
12.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
HEAVY CHAIN
EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
LIGHT CHAIN
(Mus
musculus) 		5 / 12 SER B 335
TRP B 347
SER B 350
TYR B 359
VAL A  94
 None
 0.65A 1vpoH-1i8kB:
23.0
1vpoL-1i8kB:
14.8		 1vpoH-1i8kB:
39.09
1vpoL-1i8kB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
HEAVY CHAIN
(Mus
musculus) 		6 / 11 PHE B 329
ASN B 374
GLY B 355
THR B 358
ILE B 370
LEU B 379
 None
 1.42A 1z11A-1i8kB:
0.0		 1z11A-1i8kB:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
HEAVY CHAIN
(Mus
musculus) 		6 / 11 PHE B 329
ASN B 374
GLY B 355
THR B 358
ILE B 370
LEU B 379
 None
 1.43A 1z11B-1i8kB:
0.0		 1z11B-1i8kB:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
HEAVY CHAIN
EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
LIGHT CHAIN
(Mus
musculus) 		4 / 7 SER B 350
SER B 335
VAL B 337
LEU A   4
 None
 1.05A 2hdnE-1i8kB:
undetectable
2hdnF-1i8kB:
undetectable
2hdnH-1i8kB:
undetectable		 2hdnE-1i8kB:
15.32
2hdnF-1i8kB:
15.52
2hdnH-1i8kB:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
HEAVY CHAIN
EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
LIGHT CHAIN
(Mus
musculus) 		4 / 7 SER B 335
VAL B 337
LEU A   4
SER B 350
 None
 0.98A 2hdnF-1i8kB:
undetectable
2hdnG-1i8kB:
0.0
2hdnH-1i8kB:
undetectable		 2hdnF-1i8kB:
15.52
2hdnG-1i8kB:
15.32
2hdnH-1i8kB:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6N_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
LIGHT CHAIN
(Mus
musculus) 		4 / 5 SER A  49
MET A  33
ILE A  48
TRP A  35
 None
 1.38A 3e6nA-1i8kA:
0.0		 3e6nA-1i8kA:
13.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
HEAVY CHAIN
(Mus
musculus) 		5 / 10 TRP B 347
SER B 350
TYR B 359
GLY B 399
TRP B 410
 None
 0.48A 3ls4H-1i8kB:
23.3		 3ls4H-1i8kB:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
HEAVY CHAIN
(Mus
musculus) 		4 / 7 ALA B 392
THR B 391
VAL B 416
GLU B 389
 None
 0.74A 5ecmD-1i8kB:
undetectable		 5ecmD-1i8kB:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
HEAVY CHAIN
(Mus
musculus) 		4 / 7 ALA B 392
THR B 391
VAL B 416
GLU B 389
 None
 0.82A 5ecoD-1i8kB:
0.0		 5ecoD-1i8kB:
14.11