SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		3 / 3 VAL A 959
VAL A 935
TRP A 933
 None
 0.85A 1av2A-1i8qA:
undetectable
1av2B-1i8qA:
undetectable		 1av2A-1i8qA:
1.42
1av2B-1i8qA:
1.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 7 ARG A 321
TYR A 488
ARG A 542
ASN A 660
 GC4  A1001 (-3.2A)
None
NAG  A1002 (-4.6A)
None
 0.90A 1f9gA-1i8qA:
55.1		 1f9gA-1i8qA:
53.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 7 TYR A 484
ARG A 542
ARG A 546
ASN A 660
 None
NAG  A1002 (-4.6A)
NAG  A1002 (-3.3A)
None
 1.02A 1f9gA-1i8qA:
55.1		 1f9gA-1i8qA:
53.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 7 TYR A 488
ARG A 542
ARG A 546
ASN A 660
 None
NAG  A1002 (-4.6A)
NAG  A1002 (-3.3A)
None
 0.41A 1f9gA-1i8qA:
55.1		 1f9gA-1i8qA:
53.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 8 ARG A 837
SER A 679
ASP A 798
LYS A 800
 None
 1.20A 1hwiB-1i8qA:
undetectable		 1hwiB-1i8qA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 8 ARG A 837
SER A 679
ASP A 798
LYS A 800
 None
 1.16A 1hwkA-1i8qA:
undetectable		 1hwkA-1i8qA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 8 ARG A 837
SER A 679
ASP A 798
LYS A 800
 None
 1.20A 1hwkC-1i8qA:
undetectable		 1hwkC-1i8qA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 8 ARG A 837
SER A 679
ASP A 798
LYS A 800
 None
 1.20A 1hwkD-1i8qA:
undetectable		 1hwkD-1i8qA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 10 ASP A 395
THR A 402
ILE A 405
THR A 448
ILE A 449
 None
 1.35A 1i18A-1i8qA:
0.1
1i18B-1i8qA:
0.1		 1i18A-1i8qA:
9.66
1i18B-1i8qA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 10 THR A 448
ILE A 449
ASP A 395
THR A 402
ILE A 405
 None
 1.35A 1i18A-1i8qA:
0.1
1i18B-1i8qA:
0.0		 1i18A-1i8qA:
9.66
1i18B-1i8qA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 10 GLY A 265
GLN A 329
ASN A 332
TYR A 269
THR A 263
 None
 1.31A 1kvlA-1i8qA:
undetectable		 1kvlA-1i8qA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 12 GLY A 955
ALA A 954
ALA A 749
ILE A 936
GLN A 923
 None
 1.21A 1nt2A-1i8qA:
0.0		 1nt2A-1i8qA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 4 ALA A 554
VAL A 558
ALA A 555
HIS A 552
 None
 1.03A 1q23A-1i8qA:
0.0		 1q23A-1i8qA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 4 ALA A 554
VAL A 558
ALA A 555
HIS A 552
 None
 1.05A 1q23F-1i8qA:
0.0		 1q23F-1i8qA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 4 ALA A 554
VAL A 558
ALA A 555
HIS A 552
 None
 1.06A 1q23K-1i8qA:
undetectable		 1q23K-1i8qA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		6 / 12 ILE A 936
LEU A 646
LEU A 775
GLY A 776
TYR A 893
VAL A 773
 None
 1.37A 1tlsB-1i8qA:
0.0		 1tlsB-1i8qA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 7 ARG A 546
GLU A 547
ALA A 554
ALA A 553
 NAG  A1002 (-3.3A)
None
None
None
 0.98A 2ejfA-1i8qA:
0.0		 2ejfA-1i8qA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 12 ALA A 645
GLY A 643
MET A 895
GLY A 840
LEU A 830
 None
 0.94A 2hw2A-1i8qA:
0.4		 2hw2A-1i8qA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 11 LEU A 323
LEU A 354
SER A 313
LEU A 316
LEU A 303
 None
 1.09A 2xn5A-1i8qA:
0.0		 2xn5A-1i8qA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 10 VAL A 828
PHE A 843
TYR A 893
GLY A 699
PHE A 674
 None
 1.39A 3r6wA-1i8qA:
undetectable
3r6wB-1i8qA:
undetectable		 3r6wA-1i8qA:
13.73
3r6wB-1i8qA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 9 ILE A 767
LEU A 633
ILE A 676
MET A 673
GLY A 672
 None
 1.40A 3sj4X-1i8qA:
undetectable		 3sj4X-1i8qA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		3 / 3 GLN A 856
GLU A 852
LYS A 854
 None
 1.19A 3su9A-1i8qA:
0.0		 3su9A-1i8qA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 11 THR A 400
THR A 179
VAL A 177
VAL A 347
PHE A 393
 None
 1.03A 3tbgA-1i8qA:
0.0		 3tbgA-1i8qA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 10 THR A 400
THR A 179
VAL A 177
VAL A 347
PHE A 393
 None
 1.15A 3tbgC-1i8qA:
0.0		 3tbgC-1i8qA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 8 ILE A 880
ASP A 850
ILE A 851
PHE A 822
 None
 0.72A 4ac9C-1i8qA:
undetectable		 4ac9C-1i8qA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 8 ILE A 880
ASP A 850
ILE A 851
PHE A 822
 None
 0.77A 4acaC-1i8qA:
undetectable		 4acaC-1i8qA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 8 ILE A 880
ASP A 850
ILE A 851
PHE A 822
 None
 0.77A 4acbC-1i8qA:
undetectable		 4acbC-1i8qA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 8 ILE A 767
LEU A 633
ILE A 676
MET A 673
GLY A 672
 None
 1.48A 4hb8A-1i8qA:
undetectable		 4hb8A-1i8qA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 12 LEU A 496
LEU A 492
LEU A 430
ILE A 503
ILE A 438
 None
 1.06A 4j24A-1i8qA:
0.5		 4j24A-1i8qA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 11 TYR A 591
VAL A 556
ILE A 585
MET A 606
LEU A 610
 None
 1.23A 4lhmA-1i8qA:
undetectable		 4lhmA-1i8qA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 12 GLY A 764
ALA A 748
PHE A 674
ILE A 767
ASP A 793
 None
 1.24A 4xe5A-1i8qA:
0.7		 4xe5A-1i8qA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 10 LEU A 351
LEU A 354
SER A 313
LEU A 316
LEU A 303
 None
 1.22A 4yiaA-1i8qA:
0.0		 4yiaA-1i8qA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB402_0
(GLYCINE OXIDASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 5 GLU A 657
TYR A 488
ARG A 546
ARG A 542
 None
None
NAG  A1002 (-3.3A)
NAG  A1002 (-4.6A)
 1.21A 4yshB-1i8qA:
undetectable		 4yshB-1i8qA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		3 / 3 ARG A 757
ASN A 655
ASP A 631
 None
 0.89A 5gwxA-1i8qA:
undetectable		 5gwxA-1i8qA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 7 VAL A 409
PHE A 408
ILE A 365
PHE A 415
 None
 0.85A 5hieC-1i8qA:
0.3		 5hieC-1i8qA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		3 / 3 LYS A 883
ASP A 885
ILE A 792
 None
 0.86A 5kc4E-1i8qA:
0.6		 5kc4E-1i8qA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 5 LEU A 958
LEU A 956
MET A 951
TYR A 966
 None
 1.29A 5uc3A-1i8qA:
0.0		 5uc3A-1i8qA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 5 THR A 453
GLU A 440
THR A 402
LEU A 256
 None
 1.17A 5utuH-1i8qA:
undetectable		 5utuH-1i8qA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_C_9F2C302_1
(BETA-LACTAMASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 10 THR A 825
ILE A 851
THR A 790
THR A 791
ASP A 797
 None
 1.45A 6b5yC-1i8qA:
0.0
6b5yD-1i8qA:
0.0		 6b5yC-1i8qA:
8.53
6b5yD-1i8qA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_C_9F2C302_1
(BETA-LACTAMASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 10 THR A 825
ILE A 851
THR A 790
THR A 791
ASP A 797
 None
 1.45A 6b68C-1i8qA:
0.0
6b68D-1i8qA:
0.0		 6b68C-1i8qA:
8.53
6b68D-1i8qA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_A_9F2A302_1
(BETA-LACTAMASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 9 THR A 825
ILE A 851
THR A 790
THR A 791
ASP A 797
 None
 1.40A 6b69A-1i8qA:
0.0
6b69B-1i8qA:
undetectable		 6b69A-1i8qA:
8.53
6b69B-1i8qA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_C_9F2C302_1
(BETA-LACTAMASE)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 9 THR A 825
ILE A 851
THR A 790
THR A 791
ASP A 797
 None
 1.41A 6b69C-1i8qA:
0.0
6b69D-1i8qA:
0.4		 6b69C-1i8qA:
8.53
6b69D-1i8qA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		4 / 7 ASP A 889
ASN A 778
ALA A 761
LYS A 763
 None
 1.00A 6ci6A-1i8qA:
0.0		 6ci6A-1i8qA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1i8q HYALURONATE LYASE
(Streptococcus
agalactiae) 		5 / 12 GLY A 561
GLN A 498
LEU A 515
ILE A 522
MET A 568
 None
 1.44A 6md4A-1i8qA:
undetectable		 6md4A-1i8qA:
7.04