SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		5 / 12 ILE A  57
ALA A  55
PHE A 285
PRO A  82
LEU A  93
 FAD  A 450 (-4.1A)
None
None
None
None
 1.18A 1og5B-1i8tA:
undetectable		 1og5B-1i8tA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		4 / 8 TYR A 181
PHE A 182
PHE A  78
ALA A  55
 None
 0.94A 1x8vA-1i8tA:
undetectable		 1x8vA-1i8tA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		3 / 3 TRP A 303
LEU A 301
LYS A 250
 None
 1.27A 1yajK-1i8tA:
undetectable		 1yajK-1i8tA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		4 / 7 TYR A 239
TYR A 246
TYR A 325
ILE A 233
 None
 1.10A 2ph9A-1i8tA:
0.0
2ph9B-1i8tA:
undetectable		 2ph9A-1i8tA:
22.31
2ph9B-1i8tA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		5 / 11 GLY A   8
ILE A  30
GLU A  31
HIS A  35
ASP A 212
 FAD  A 450 (-3.2A)
None
FAD  A 450 (-2.8A)
None
FAD  A 450 (-3.5A)
 1.00A 3dxyA-1i8tA:
2.1		 3dxyA-1i8tA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		5 / 12 VAL A   7
TYR A 236
LEU A 214
ALA A 221
SER A 219
 FAD  A 450 (-4.7A)
None
FAD  A 450 ( 4.1A)
None
None
 1.00A 3pghC-1i8tA:
undetectable		 3pghC-1i8tA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		5 / 12 VAL A   7
TYR A 236
LEU A 214
ALA A 221
SER A 219
 FAD  A 450 (-4.7A)
None
FAD  A 450 ( 4.1A)
None
None
 1.04A 3rr3C-1i8tA:
0.0		 3rr3C-1i8tA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		5 / 12 VAL A 352
VAL A  27
ILE A 198
LEU A 202
VAL A 205
 FAD  A 450 ( 4.7A)
None
None
None
None
 1.02A 3w68D-1i8tA:
undetectable		 3w68D-1i8tA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		4 / 7 ILE A 227
ARG A 226
ILE A   5
ALA A 224
 None
 0.92A 4lv9B-1i8tA:
undetectable		 4lv9B-1i8tA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		3 / 3 THR A 290
ASN A  76
PHE A  78
 None
 0.77A 4pd9A-1i8tA:
undetectable		 4pd9A-1i8tA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		4 / 6 TYR A 346
ILE A  57
TYR A 181
TYR A 151
 FAD  A 450 (-4.7A)
FAD  A 450 (-4.1A)
None
None
 0.89A 5igyA-1i8tA:
0.0		 5igyA-1i8tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		4 / 6 TYR A 346
ILE A  57
TYR A 181
TYR A 151
 FAD  A 450 (-4.7A)
FAD  A 450 (-4.1A)
None
None
 0.95A 5ih0A-1i8tA:
0.0		 5ih0A-1i8tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		4 / 7 GLY A   8
GLU A  31
LYS A  32
ASP A 212
 FAD  A 450 (-3.2A)
FAD  A 450 (-2.8A)
FAD  A 450 (-3.8A)
FAD  A 450 (-3.5A)
 0.59A 5mvsA-1i8tA:
3.0		 5mvsA-1i8tA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		5 / 12 GLY A 193
VAL A 207
LEU A 209
GLY A  37
ILE A 198
 None
 1.19A 5vooA-1i8tA:
undetectable		 5vooA-1i8tA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		5 / 12 GLY A 193
VAL A 207
LEU A 209
GLY A  37
ILE A 198
 None
 1.16A 5vooC-1i8tA:
undetectable		 5vooC-1i8tA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		5 / 11 VAL A   7
GLY A   8
GLU A  31
LYS A  32
ASP A 212
 FAD  A 450 (-4.7A)
FAD  A 450 (-3.2A)
FAD  A 450 (-2.8A)
FAD  A 450 (-3.8A)
FAD  A 450 (-3.5A)
 0.79A 5x6yA-1i8tA:
undetectable		 5x6yA-1i8tA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		5 / 10 VAL A   7
GLY A   8
GLU A  31
LYS A  32
ASP A 212
 FAD  A 450 (-4.7A)
FAD  A 450 (-3.2A)
FAD  A 450 (-2.8A)
FAD  A 450 (-3.8A)
FAD  A 450 (-3.5A)
 0.74A 5x6yB-1i8tA:
2.0		 5x6yB-1i8tA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		5 / 11 VAL A   7
GLY A   8
GLU A  31
LYS A  32
ASP A 212
 FAD  A 450 (-4.7A)
FAD  A 450 (-3.2A)
FAD  A 450 (-2.8A)
FAD  A 450 (-3.8A)
FAD  A 450 (-3.5A)
 0.51A 5x6yC-1i8tA:
undetectable		 5x6yC-1i8tA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		4 / 8 LEU A 202
VAL A 205
VAL A 207
ILE A   6
 None
 0.75A 5y9mA-1i8tA:
undetectable		 5y9mA-1i8tA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		5 / 12 GLY A 231
TYR A 239
TYR A 325
VAL A 335
GLY A 338
 FAD  A 450 (-3.5A)
None
None
None
None
 1.40A 6gngA-1i8tA:
2.5		 6gngA-1i8tA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		4 / 5 LEU A 147
THR A 270
THR A 152
GLY A 150
 None
 1.15A 6gtqA-1i8tA:
0.0		 6gtqA-1i8tA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 1i8t UDP-GALACTOPYRANOSE
MUTASE
(Escherichia
coli) 		4 / 5 GLY A 231
LEU A 341
TYR A 239
GLN A 235
 FAD  A 450 (-3.5A)
None
None
None
 1.25A 6ji6A-1i8tA:
0.0		 6ji6A-1i8tA:
21.08