SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i9a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		4 / 4 ARG A 103
LEU A   9
ASN A  10
VAL A 117
 None
 1.49A 1lqtA-1i9aA:
undetectable		 1lqtA-1i9aA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		4 / 4 ARG A 103
LEU A   9
ASN A  10
VAL A 117
 None
 1.49A 1lqtB-1i9aA:
0.0		 1lqtB-1i9aA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		4 / 4 ARG A 103
LEU A   9
ASN A  10
VAL A 117
 None
 1.49A 1lquA-1i9aA:
undetectable		 1lquA-1i9aA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		4 / 4 ARG A 103
LEU A   9
ASN A  10
VAL A 117
 None
 1.49A 1lquB-1i9aA:
0.0		 1lquB-1i9aA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		3 / 3 ALA A  52
VAL A  61
TRP A  58
 None
 0.79A 1tkqB-1i9aA:
undetectable		 1tkqB-1i9aA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		4 / 7 ARG A  83
GLU A  77
PRO A  95
ALA A 123
 None
 1.28A 2ejgA-1i9aA:
undetectable		 2ejgA-1i9aA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		5 / 12 ARG A  83
ARG A  82
GLU A 116
TYR A 104
ARG A  51
 None
None
MN  A1001 (-3.1A)
None
None
 1.30A 2f0zA-1i9aA:
undetectable		 2f0zA-1i9aA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		5 / 12 GLU A 114
GLU A 116
PHE A  35
SER A 159
TYR A 104
 MN  A1001 (-1.9A)
MN  A1001 (-3.1A)
None
None
None
 1.36A 3bjmB-1i9aA:
undetectable		 3bjmB-1i9aA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		3 / 3 HIS A  25
HIS A  32
HIS A  69
 MN  A1001 (-3.4A)
MN  A1001 (-3.4A)
MN  A1001 (-3.1A)
 0.50A 3qpkA-1i9aA:
undetectable		 3qpkA-1i9aA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		3 / 3 HIS A  25
HIS A  32
HIS A  69
 MN  A1001 (-3.4A)
MN  A1001 (-3.4A)
MN  A1001 (-3.1A)
 0.48A 3qpkB-1i9aA:
undetectable		 3qpkB-1i9aA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		5 / 12 HIS A  69
GLY A  68
VAL A 117
ALA A  24
ALA A  23
 MN  A1001 (-3.1A)
None
None
None
None
 0.80A 3sudD-1i9aA:
undetectable		 3sudD-1i9aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		5 / 12 HIS A  69
GLY A  68
VAL A 117
ALA A  24
ALA A  23
 MN  A1001 (-3.1A)
None
None
None
None
 0.85A 3sueC-1i9aA:
undetectable		 3sueC-1i9aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		5 / 12 HIS A  69
GLY A  68
VAL A 117
ALA A  24
ALA A  23
 MN  A1001 (-3.1A)
None
None
None
None
 0.78A 3sufD-1i9aA:
undetectable		 3sufD-1i9aA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		4 / 5 GLU A 135
LYS A  21
ARG A  51
GLU A  87
 None
 1.25A 3tj7C-1i9aA:
undetectable		 3tj7C-1i9aA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		3 / 3 SER A 159
GLU A  87
GLU A  74
 None
 0.87A 4ymgB-1i9aA:
undetectable		 4ymgB-1i9aA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		3 / 3 VAL A  61
SER A 159
TRP A  58
 None
 0.77A 5jwaA-1i9aA:
undetectable		 5jwaA-1i9aA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		3 / 3 HIS A  25
HIS A  32
HIS A  69
 MN  A1001 (-3.4A)
MN  A1001 (-3.4A)
MN  A1001 (-3.1A)
 0.50A 5migA-1i9aA:
undetectable		 5migA-1i9aA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		5 / 12 HIS A  69
GLY A  68
VAL A 117
ALA A  24
ALA A  23
 MN  A1001 (-3.1A)
None
None
None
None
 0.98A 6c2mD-1i9aA:
undetectable		 6c2mD-1i9aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Escherichia
coli) 		3 / 3 VAL A 136
GLU A 135
ILE A 131
 None
 0.66A 6f7lB-1i9aA:
undetectable		 6f7lB-1i9aA:
16.70