SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i9g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		5 / 10 PHE A  98
PRO A  99
VAL A 121
ILE A 128
GLY A 125
 None
 1.25A 13gsA-1i9gA:
0.0		 13gsA-1i9gA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		5 / 9 PHE A  98
PRO A  99
VAL A 121
ILE A 128
GLY A 125
 None
 1.25A 13gsB-1i9gA:
0.0		 13gsB-1i9gA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 7 ALA A  60
HIS A  34
THR A  35
SER A  57
 None
 0.91A 1c9sT-1i9gA:
1.2
1c9sU-1i9gA:
1.2		 1c9sT-1i9gA:
15.33
1c9sU-1i9gA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 8 SER A 160
VAL A 159
LEU A 157
VAL A 144
 None
 1.09A 1fduB-1i9gA:
6.8		 1fduB-1i9gA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 7 ALA A  60
HIS A  34
THR A  35
SER A  57
 None
 0.89A 1gtfL-1i9gA:
1.2
1gtfM-1i9gA:
1.2		 1gtfL-1i9gA:
15.33
1gtfM-1i9gA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 8 ALA A  60
HIS A  34
THR A  35
SER A  57
 None
 0.88A 1gtfN-1i9gA:
1.2
1gtfO-1i9gA:
1.2		 1gtfN-1i9gA:
15.33
1gtfO-1i9gA:
15.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		12 / 12 ILE A  83
GLY A 107
GLY A 109
SER A 110
ALA A 112
LEU A 113
GLN A 132
ARG A 133
ASP A 161
LEU A 162
MET A 179
VAL A 185
 SAM  A 301 (-4.0A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.7A)
None
 0.00A 1i9gA-1i9gA:
42.1		 1i9gA-1i9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 131
HIS A 136
ASP A 178
 SAM  A 301 (-2.6A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
 0.00A 1i9gA-1i9gA:
42.1		 1i9gA-1i9gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 105
GLY A 107
GLU A 131
ASP A 161
 None
SAM  A 301 (-2.7A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.4A)
 0.47A 1jg4A-1i9gA:
13.5		 1jg4A-1i9gA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 186
VAL A 189
LEU A 193
 None
 0.30A 1mz9B-1i9gA:
undetectable		 1mz9B-1i9gA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 104
VAL A 185
GLY A 107
ALA A 108
THR A 114
 None
None
SAM  A 301 (-2.7A)
None
None
 1.03A 1r9oA-1i9gA:
undetectable		 1r9oA-1i9gA:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		6 / 12 GLY A 107
GLY A 109
ARG A 133
HIS A 136
ASP A 161
MET A 179
 SAM  A 301 (-2.7A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
 0.60A 2b25A-1i9gA:
26.3		 2b25A-1i9gA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		6 / 12 GLY A 109
SER A 110
ARG A 133
HIS A 136
ASP A 161
MET A 179
 SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
None
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
 0.58A 2b25B-1i9gA:
27.3		 2b25B-1i9gA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		6 / 12 GLY A 109
SER A 110
GLY A 111
ARG A 133
HIS A 136
MET A 179
 SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 (-4.2A)
None
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
 1.04A 2b25B-1i9gA:
27.3		 2b25B-1i9gA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 107
GLU A 131
ASP A 178
 SAM  A 301 (-2.7A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.4A)
 0.20A 2b25B-1i9gA:
27.3		 2b25B-1i9gA:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 5 TRP A 155
ALA A 108
LEU A 118
ALA A 140
 None
 1.32A 2jstA-1i9gA:
0.0
2jstB-1i9gA:
0.0		 2jstA-1i9gA:
12.92
2jstB-1i9gA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		5 / 11 SER A 171
LEU A 177
LEU A 199
LEU A 193
LEU A 186
 None
 1.02A 2xn5A-1i9gA:
0.1		 2xn5A-1i9gA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  83
GLY A 107
GLY A 109
SER A 110
ALA A 112
LEU A 113
 SAM  A 301 (-4.0A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
 0.38A 2yvlA-1i9gA:
27.6		 2yvlA-1i9gA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  83
GLY A 107
GLY A 109
ALA A 112
LEU A 113
ASP A 178
 SAM  A 301 (-4.0A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
 0.37A 2yvlB-1i9gA:
27.7		 2yvlB-1i9gA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  83
GLY A 109
SER A 110
ALA A 112
LEU A 113
ASP A 178
 SAM  A 301 (-4.0A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
 0.38A 2yvlC-1i9gA:
27.5		 2yvlC-1i9gA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		7 / 12 ILE A  83
GLY A 107
GLY A 109
ALA A 112
LEU A 113
ASP A 161
ASP A 178
 SAM  A 301 (-4.0A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
 0.42A 2yvlD-1i9gA:
27.4		 2yvlD-1i9gA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 167
VAL A 185
ARG A 191
 None
 0.81A 3b0wB-1i9gA:
0.0		 3b0wB-1i9gA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		6 / 11 GLU A 105
GLY A 107
GLY A 109
GLU A 131
HIS A 136
ASP A 161
 None
SAM  A 301 (-2.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
 0.93A 3dxyA-1i9gA:
14.7		 3dxyA-1i9gA:
24.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 109
SER A 110
ALA A 112
LEU A 113
ARG A 133
 SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
None
 0.29A 3mb5A-1i9gA:
29.8		 3mb5A-1i9gA:
35.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 107
GLU A 131
ASP A 161
ASP A 178
 SAM  A 301 (-2.7A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
 0.36A 3mb5A-1i9gA:
29.8		 3mb5A-1i9gA:
35.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  97
ALA A 253
LEU A 117
LEU A 255
LEU A 199
 None
 1.06A 3vw1B-1i9gA:
0.0		 3vw1B-1i9gA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 109
GLU A 131
ASP A 161
ASP A 178
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
 0.66A 3vywC-1i9gA:
12.0		 3vywC-1i9gA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 107
GLY A 111
ASP A 161
ASP A 178
MET A 179
 SAM  A 301 (-2.7A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
 0.91A 4b17A-1i9gA:
13.0		 4b17A-1i9gA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  87
ARG A 226
THR A 252
 None
 0.88A 4i13A-1i9gA:
2.6		 4i13A-1i9gA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  87
ARG A 226
THR A 252
 None
 0.88A 4p3rA-1i9gA:
2.6		 4p3rA-1i9gA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 4 GLY A  47
LEU A  15
PHE A  62
ILE A  40
 None
 0.91A 4xv2A-1i9gA:
0.0		 4xv2A-1i9gA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 107
GLY A 109
LEU A 113
HIS A 136
ASP A 178
 SAM  A 301 (-2.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
 0.37A 5c0oE-1i9gA:
27.8		 5c0oE-1i9gA:
38.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		6 / 12 GLY A 109
GLY A 111
LEU A 113
GLU A 131
HIS A 136
ASP A 178
 SAM  A 301 (-3.4A)
SAM  A 301 (-4.2A)
SAM  A 301 (-4.5A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
 0.91A 5c0oF-1i9gA:
26.8		 5c0oF-1i9gA:
38.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 131
HIS A 136
ASP A 178
 SAM  A 301 (-2.6A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
 0.29A 5c0oG-1i9gA:
28.6		 5c0oG-1i9gA:
38.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		7 / 12 GLY A 107
GLY A 109
SER A 110
GLY A 111
LEU A 113
ARG A 133
LEU A 162
 SAM  A 301 (-2.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 (-4.2A)
SAM  A 301 (-4.5A)
None
None
 0.91A 5c0oH-1i9gA:
28.3		 5c0oH-1i9gA:
38.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 8 SER A  57
ALA A  60
HIS A  34
THR A  35
 None
 0.86A 5eevL-1i9gA:
1.2
5eevV-1i9gA:
1.2		 5eevL-1i9gA:
15.33
5eevV-1i9gA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 8 SER A  57
ALA A  60
HIS A  34
THR A  35
 None
 0.86A 5eewL-1i9gA:
1.2
5eewV-1i9gA:
1.2		 5eewL-1i9gA:
15.33
5eewV-1i9gA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 8 SER A  57
ALA A  60
HIS A  34
THR A  35
 None
 0.86A 5eezL-1i9gA:
1.2
5eezV-1i9gA:
1.2		 5eezL-1i9gA:
15.33
5eezV-1i9gA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 8 SER A  57
ALA A  60
HIS A  34
THR A  35
 None
 0.87A 5ef1L-1i9gA:
1.2
5ef1V-1i9gA:
1.2		 5ef1L-1i9gA:
15.33
5ef1V-1i9gA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 8 SER A  57
ALA A  60
HIS A  34
THR A  35
 None
 0.86A 5ef2L-1i9gA:
1.2
5ef2V-1i9gA:
1.2		 5ef2L-1i9gA:
15.33
5ef2V-1i9gA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 8 SER A  57
ALA A  60
HIS A  34
THR A  35
 None
 0.86A 5ef3L-1i9gA:
1.2
5ef3V-1i9gA:
1.3		 5ef3L-1i9gA:
15.33
5ef3V-1i9gA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		6 / 7 GLY A 107
GLY A 109
SER A 110
GLU A 131
ASP A 161
ASP A 178
 SAM  A 301 (-2.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
 0.63A 5ergB-1i9gA:
23.7		 5ergB-1i9gA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 161
ASP A 178
GLY A 109
SER A 110
GLU A 131
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 (-2.6A)
 1.04A 5hfjF-1i9gA:
4.1		 5hfjF-1i9gA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 5 THR A 252
HIS A 251
ALA A 253
ASP A  87
 None
 1.32A 5mfxA-1i9gA:
2.9		 5mfxA-1i9gA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CR0_A_ACTA506_0
((S)-6-HYDROXYNICOTIN
E OXIDASE)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 204
HIS A 251
TYR A  84
LYS A  86
 None
 1.23A 6cr0A-1i9gA:
2.2		 6cr0A-1i9gA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 1i9g HYPOTHETICAL PROTEIN
RV2118C
(Mycobacterium
tuberculosis) 		5 / 12 ARG A 141
VAL A 144
ALA A 140
GLY A 111
LEU A 118
 None
None
None
SAM  A 301 (-4.2A)
None
 0.94A 6f6iA-1i9gA:
0.0
6f6iB-1i9gA:
0.0		 6f6iA-1i9gA:
14.98
6f6iB-1i9gA:
14.39