SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i9i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
(Mus
musculus) 		7 / 11 SER H  35
TRP H  47
SER H  50
VAL H  52
TYR H  58
GLY H 104
LEU H 105
 None
 0.31A 1i9jH-1i9iH:
31.5
1i9jL-1i9iH:
15.2		 1i9jH-1i9iH:
100.00
1i9jL-1i9iH:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
(Mus
musculus) 		6 / 12 SER H  35
TRP H  47
SER H  50
TYR H  58
GLY H 104
LEU H 105
 None
 0.40A 1vpoH-1i9iH:
30.3
1vpoL-1i9iH:
15.7		 1vpoH-1i9iH:
97.73
1vpoL-1i9iH:
28.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
(Mus
musculus) 		4 / 8 PHE H  29
ILE H  73
GLY H  55
GLY H  54
 None
 0.74A 2qx4A-1i9iH:
undetectable
2qx4B-1i9iH:
undetectable		 2qx4A-1i9iH:
25.40
2qx4B-1i9iH:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
(Mus
musculus) 		4 / 6 PHE H  29
ILE H  73
GLY H  55
GLY H  54
 None
 0.79A 2qx6A-1i9iH:
undetectable
2qx6B-1i9iH:
undetectable		 2qx6A-1i9iH:
25.40
2qx6B-1i9iH:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
(Mus
musculus) 		5 / 12 VAL H 168
VAL H 186
SER H 184
ASN H 201
ASN H 160
 None
 1.40A 2y03A-1i9iH:
undetectable		 2y03A-1i9iH:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
(Mus
musculus) 		5 / 12 VAL H 168
VAL H 186
SER H 184
ASN H 201
ASN H 160
 None
 1.45A 2y03B-1i9iH:
undetectable		 2y03B-1i9iH:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
(Mus
musculus) 		4 / 5 TYR H  94
MET H  92
THR H 112
LEU H 113
 None
 1.46A 3ag4J-1i9iH:
undetectable		 3ag4J-1i9iH:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
(Mus
musculus) 		5 / 12 VAL H 168
VAL H 186
SER H 184
ASN H 201
ASN H 160
 None
 1.35A 3nyaA-1i9iH:
undetectable		 3nyaA-1i9iH:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
(Mus
musculus) 		4 / 7 ALA H  91
THR H  90
VAL H 114
GLU H  88
 None
 0.73A 5ecmD-1i9iH:
0.0		 5ecmD-1i9iH:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
(Mus
musculus) 		4 / 7 ALA H  91
THR H  90
VAL H 114
GLU H  88
 None
 0.84A 5ecoD-1i9iH:
0.0		 5ecoD-1i9iH:
18.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
(Mus
musculus) 		4 / 5 SER H 117
ALA H 119
PHE H 151
LEU H 175
 None
 0.41A 5mthA-1i9iH:
27.9		 5mthA-1i9iH:
72.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
(Mus
musculus) 		3 / 3 TYR H  59
GLY H  65
THR H  68
 None
 0.15A 6cjkB-1i9iH:
25.9		 6cjkB-1i9iH:
57.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
(Mus
musculus) 		5 / 12 VAL H 168
VAL H 186
SER H 184
ASN H 201
ASN H 160
 None
 1.44A 6h7mB-1i9iH:
undetectable		 6h7mB-1i9iH:
21.50