SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1i9z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 7 GLY A 680
HIS A 699
THR A 670
ILE A 717
 None
 0.94A 1gtnF-1i9zA:
undetectable
1gtnG-1i9zA:
undetectable		 1gtnF-1i9zA:
13.15
1gtnG-1i9zA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU A 761
SER A 762
TRP A 814
PHE A 790
 None
 1.04A 1ismB-1i9zA:
undetectable		 1ismB-1i9zA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU A 770
PHE A 780
PHE A 730
PHE A 783
 None
 0.90A 1wrlC-1i9zA:
undetectable
1wrlD-1i9zA:
undetectable		 1wrlC-1i9zA:
12.28
1wrlD-1i9zA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 ARG A 744
HIS A 839
ASP A 816
ALA A 702
 2IP  A 302 (-2.8A)
None
None
2IP  A 302 ( 3.8A)
 0.94A 2rk8A-1i9zA:
3.1		 2rk8A-1i9zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		3 / 3 SER A 640
HIS A 699
ASP A 816
 None
 0.70A 2wa2B-1i9zA:
undetectable		 2wa2B-1i9zA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 4 ARG A 727
GLY A 665
GLU A 664
SER A 698
 None
 1.23A 2xctS-1i9zA:
0.0
2xctU-1i9zA:
0.2		 2xctS-1i9zA:
18.61
2xctU-1i9zA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 744
ASP A 713
ASN A 706
 2IP  A 302 (-2.8A)
None
None
 0.58A 2zzmA-1i9zA:
1.8		 2zzmA-1i9zA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		3 / 4 SER A 837
GLY A 739
GLU A 785
 None
 0.60A 3raeA-1i9zA:
0.0
3raeC-1i9zA:
0.0		 3raeA-1i9zA:
19.61
3raeC-1i9zA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 TYR A 836
THR A 574
TYR A 565
TRP A 617
 None
 1.49A 3wipB-1i9zA:
undetectable
3wipC-1i9zA:
undetectable		 3wipB-1i9zA:
20.73
3wipC-1i9zA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 TYR A 836
THR A 574
TYR A 565
TRP A 617
 None
 1.47A 3wipC-1i9zA:
undetectable
3wipD-1i9zA:
undetectable		 3wipC-1i9zA:
20.73
3wipD-1i9zA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 TRP A 617
TYR A 836
THR A 574
TYR A 565
 None
 1.36A 3wipA-1i9zA:
0.0
3wipE-1i9zA:
0.0		 3wipA-1i9zA:
20.73
3wipE-1i9zA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		3 / 4 SER A 837
GLY A 739
GLU A 785
 None
 0.61A 4juoA-1i9zA:
0.0
4juoC-1i9zA:
undetectable		 4juoA-1i9zA:
19.61
4juoC-1i9zA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 VAL A 736
LEU A 824
ASP A 589
ILE A 590
 None
 0.79A 4lzrA-1i9zA:
undetectable		 4lzrA-1i9zA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 686
ILE A 660
TYR A 688
PHE A 695
HIS A 827
 None
 1.21A 5esgA-1i9zA:
undetectable		 5esgA-1i9zA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 686
ILE A 660
TYR A 688
PHE A 695
HIS A 827
 None
 1.17A 5eslA-1i9zA:
0.0		 5eslA-1i9zA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 686
ILE A 660
TYR A 688
PHE A 695
HIS A 827
 None
 1.17A 5jlcA-1i9zA:
undetectable		 5jlcA-1i9zA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 686
ILE A 660
TYR A 688
PHE A 695
HIS A 827
 None
 1.28A 5v5zA-1i9zA:
undetectable		 5v5zA-1i9zA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 7 ASN A 742
HIS A 699
GLY A 569
ASN A 566
 None
None
None
CA  A 301 ( 4.6A)
 1.13A 5x7pA-1i9zA:
undetectable		 5x7pA-1i9zA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 6 ARG A 614
GLY A 641
THR A 646
VAL A 682
 None
 0.85A 5ysiA-1i9zA:
0.0		 5ysiA-1i9zA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 TRP A 814
THR A 793
TYR A 803
LEU A 761
 None
 1.28A 6cnjD-1i9zA:
0.0
6cnjE-1i9zA:
0.0		 6cnjD-1i9zA:
14.58
6cnjE-1i9zA:
12.94