SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ia5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		4 / 8 TYR A 262
TYR A 270
LEU A 303
SER A 305
 None
 1.09A 1i7zA-1ia5A:
undetectable		 1i7zA-1ia5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		3 / 3 ASP A 181
PHE A 222
VAL A 185
 None
 0.69A 1kijB-1ia5A:
0.0		 1kijB-1ia5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		4 / 8 SER A 274
SER A 275
ASN A 269
ILE A 240
 None
 1.00A 1meiA-1ia5A:
undetectable		 1meiA-1ia5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 10 VAL A  26
LEU A  27
LEU A 120
GLY A  78
ALA A  79
 None
 1.10A 1pxxA-1ia5A:
0.0		 1pxxA-1ia5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 9 VAL A  26
LEU A  27
LEU A 120
GLY A  78
ALA A  79
 None
 1.12A 1pxxB-1ia5A:
undetectable		 1pxxB-1ia5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		6 / 12 VAL A  26
LEU A  27
SER A  28
LEU A 120
GLY A  78
ALA A  79
 None
 1.17A 1pxxC-1ia5A:
0.0		 1pxxC-1ia5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 10 VAL A  26
LEU A  27
LEU A 120
GLY A  78
ALA A  79
 None
 1.11A 1pxxD-1ia5A:
undetectable		 1pxxD-1ia5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		3 / 3 LYS A 237
ILE A 283
THR A 278
 None
 0.79A 1rx3A-1ia5A:
undetectable		 1rx3A-1ia5A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 12 ALA A  15
VAL A  32
ALA A  31
PHE A  57
PHE A  51
 None
 1.04A 1uduB-1ia5A:
undetectable		 1uduB-1ia5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		4 / 7 PHE A 107
LEU A 112
PHE A  51
VAL A  26
 None
 1.11A 1wrlA-1ia5A:
undetectable
1wrlB-1ia5A:
undetectable		 1wrlA-1ia5A:
12.68
1wrlB-1ia5A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		3 / 3 SER A 225
VAL A 183
LEU A 204
 None
 0.71A 1yajG-1ia5A:
0.6		 1yajG-1ia5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		3 / 3 ASP A 159
ILE A 206
VAL A 169
 None
 0.69A 2avvD-1ia5A:
undetectable		 2avvD-1ia5A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 12 TRP A  92
GLY A 155
GLY A 154
ASN A 147
ASP A 181
 None
 1.04A 2dpmA-1ia5A:
undetectable		 2dpmA-1ia5A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		4 / 8 VAL A 220
THR A 221
VAL A 234
ILE A 236
 None
 0.92A 2qbmA-1ia5A:
undetectable		 2qbmA-1ia5A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		4 / 8 PHE A 107
ILE A  84
PHE A 130
GLY A 119
 None
 0.90A 2qwxA-1ia5A:
undetectable
2qwxB-1ia5A:
undetectable		 2qwxA-1ia5A:
20.95
2qwxB-1ia5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		4 / 8 PHE A 107
ILE A  84
PHE A 130
GLY A 119
 None
 0.87A 2qx4A-1ia5A:
undetectable
2qx4B-1ia5A:
undetectable		 2qx4A-1ia5A:
21.23
2qx4B-1ia5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		4 / 8 PHE A 107
ILE A  84
PHE A 130
GLY A 119
 None
 0.88A 2qx4A-1ia5A:
undetectable
2qx4B-1ia5A:
undetectable		 2qx4A-1ia5A:
21.23
2qx4B-1ia5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 10 GLY A 201
ASP A 231
GLY A 263
LEU A 256
SER A 294
 None
 0.97A 2v3kA-1ia5A:
undetectable		 2v3kA-1ia5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 12 GLY A 207
VAL A 209
ILE A 236
ALA A 184
VAL A 220
 None
 0.98A 3fpjA-1ia5A:
undetectable		 3fpjA-1ia5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 9 ALA A  15
LEU A  38
VAL A  49
ILE A  84
LEU A 120
 None
 1.19A 3jw3B-1ia5A:
undetectable		 3jw3B-1ia5A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		4 / 8 VAL A 281
VAL A 249
ILE A 236
GLN A 268
 None
 0.94A 3remA-1ia5A:
undetectable		 3remA-1ia5A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		4 / 8 VAL A 281
VAL A 249
ILE A 236
GLN A 268
 None
 0.93A 3remB-1ia5A:
undetectable		 3remB-1ia5A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 12 VAL A  26
LEU A  27
SER A  28
GLY A  78
ALA A  79
 None
 0.97A 4coxC-1ia5A:
undetectable		 4coxC-1ia5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		4 / 8 PHE A 107
ILE A  84
PHE A 130
GLY A 119
 None
 1.00A 4fgjA-1ia5A:
undetectable
4fgjB-1ia5A:
undetectable		 4fgjA-1ia5A:
21.23
4fgjB-1ia5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		3 / 3 LYS A 237
ILE A 283
THR A 278
 None
 0.82A 4gh8A-1ia5A:
undetectable		 4gh8A-1ia5A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		6 / 12 VAL A  26
LEU A  27
SER A  28
LEU A 120
GLY A  78
ALA A  79
 None
 1.44A 4otyA-1ia5A:
0.0		 4otyA-1ia5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		6 / 12 VAL A  26
LEU A  27
SER A  28
LEU A 120
GLY A  78
ALA A  79
 None
 1.43A 4otyB-1ia5A:
0.0		 4otyB-1ia5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 12 VAL A  26
LEU A  27
SER A  28
GLY A  78
ALA A  79
 None
 1.04A 4rrwD-1ia5A:
0.0		 4rrwD-1ia5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 12 VAL A  26
LEU A  27
SER A  28
GLY A  78
ALA A  79
 None
 1.04A 4rrzD-1ia5A:
0.0		 4rrzD-1ia5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 9 VAL A  26
LEU A  27
SER A  28
GLY A  78
ALA A  79
 None
 1.01A 4rs0A-1ia5A:
undetectable		 4rs0A-1ia5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		4 / 7 GLY A 299
SER A 297
GLY A 323
ALA A 260
 None
 1.01A 5e26A-1ia5A:
undetectable
5e26B-1ia5A:
undetectable		 5e26A-1ia5A:
21.04
5e26B-1ia5A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 12 GLY A   8
GLY A  11
LEU A  40
PHE A 107
THR A  75
 MAN  A 407 ( 4.8A)
MAN  A 414 ( 4.7A)
None
None
None
 1.08A 5eqbA-1ia5A:
0.0		 5eqbA-1ia5A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 12 VAL A  26
SER A  28
LEU A 120
GLY A  78
ALA A  79
 None
 1.13A 5iktA-1ia5A:
undetectable		 5iktA-1ia5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 12 VAL A  26
SER A  28
LEU A 120
GLY A  78
ALA A  79
 None
 1.14A 5iktB-1ia5A:
undetectable		 5iktB-1ia5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		4 / 5 TYR A 270
GLN A 267
ASN A 269
THR A 273
 None
 1.22A 6d8pA-1ia5A:
0.0		 6d8pA-1ia5A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		4 / 6 GLY A 233
ASN A 232
SER A 205
ARG A 235
 None
 1.06A 6dwdA-1ia5A:
0.0
6dwdC-1ia5A:
0.0		 6dwdA-1ia5A:
20.78
6dwdC-1ia5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 12 LEU A  38
ILE A  67
GLY A  86
PHE A  57
ILE A 122
 None
 1.08A 6qxsB-1ia5A:
0.0		 6qxsB-1ia5A:
21.26