SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ia7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		4 / 8 ALA A 223
LEU A 181
ALA A 184
LYS A 185
 None
 0.66A 1e7cA-1ia7A:
0.9		 1e7cA-1ia7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		4 / 5 SER A 208
TYR A 117
SER A  70
ASP A 257
 CA  A1332 (-2.5A)
None
None
EDO  A1337 ( 3.5A)
 1.48A 1vidA-1ia7A:
0.0		 1vidA-1ia7A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		4 / 4 LEU A  10
SER A   7
TYR A   6
LEU A 423
 None
 1.33A 1xz3A-1ia7A:
0.0		 1xz3A-1ia7A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		4 / 5 ILE A  73
ILE A 154
MET A 254
LEU A 162
 None
 0.90A 1zgyA-1ia7A:
0.0		 1zgyA-1ia7A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		4 / 8 LYS A  62
HIS A  39
ASP A  42
ALA A  26
 None
ZN  A1333 (-3.1A)
None
None
 1.34A 2rk8A-1ia7A:
undetectable		 2rk8A-1ia7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		5 / 12 LEU A  74
GLY A  75
TRP A 256
ASP A 414
ASP A 257
 None
None
SO4  A1335 (-4.1A)
SO4  A1335 ( 4.3A)
EDO  A1337 ( 3.5A)
 1.16A 3eeoA-1ia7A:
undetectable		 3eeoA-1ia7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		4 / 7 VAL A 390
ILE A 340
TYR A 350
ILE A 351
 None
 0.90A 3hgxA-1ia7A:
undetectable		 3hgxA-1ia7A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2U_A_ELVA397_1
(INTEGRASE)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		4 / 5 ASP A 250
ASP A 258
TYR A  69
PRO A 262
 None
EDO  A1337 (-4.4A)
None
None
 1.45A 3l2uA-1ia7A:
undetectable		 3l2uA-1ia7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		4 / 5 ASP A 250
ASP A 258
TYR A  69
PRO A 262
 None
EDO  A1337 (-4.4A)
None
None
 1.47A 3l2wA-1ia7A:
undetectable		 3l2wA-1ia7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		4 / 7 GLU A 313
SER A 314
VAL A 316
VAL A 422
 None
 0.95A 3n61A-1ia7A:
0.0
3n61B-1ia7A:
0.0		 3n61A-1ia7A:
21.41
3n61B-1ia7A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		4 / 8 GLU A 313
SER A 314
VAL A 316
VAL A 422
 None
 0.94A 3nlrA-1ia7A:
0.0
3nlrB-1ia7A:
0.0		 3nlrA-1ia7A:
21.41
3nlrB-1ia7A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		4 / 5 SER A 159
THR A 163
GLU A 157
ASP A 258
 None
None
None
EDO  A1337 (-4.4A)
 1.30A 3tm4A-1ia7A:
undetectable		 3tm4A-1ia7A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		4 / 5 SER A 159
THR A 163
GLU A 157
ASP A 258
 None
None
None
EDO  A1337 (-4.4A)
 1.27A 3tm4B-1ia7A:
undetectable		 3tm4B-1ia7A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		5 / 10 HIS A 363
GLN A  67
PHE A  63
GLY A  64
GLY A  58
 BGC  A 442 ( 3.9A)
None
None
None
BGC  A 442 ( 4.9A)
 1.44A 3v3oD-1ia7A:
undetectable		 3v3oD-1ia7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		5 / 12 ASP A  56
GLY A  64
GLY A  68
LEU A 142
GLY A 122
 None
 1.24A 4blvB-1ia7A:
undetectable		 4blvB-1ia7A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		5 / 12 GLY A  64
GLY A  68
LEU A 142
GLY A 120
ASP A  56
 None
 1.09A 4blvB-1ia7A:
undetectable		 4blvB-1ia7A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		4 / 7 LEU A 332
ALA A 310
VAL A 337
ILE A  73
 None
 0.95A 4eyrA-1ia7A:
undetectable		 4eyrA-1ia7A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		3 / 3 LEU A 419
LEU A  98
ASN A  90
 None
 0.67A 4otwA-1ia7A:
undetectable		 4otwA-1ia7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		5 / 12 GLY A 392
GLY A 305
LEU A 389
ASN A 303
LEU A 298
 None
 1.30A 4x61A-1ia7A:
undetectable		 4x61A-1ia7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		5 / 12 ASP A 414
ALA A 311
ALA A 312
MET A 315
VAL A 316
 SO4  A1335 ( 4.3A)
None
None
None
None
 1.11A 5igjA-1ia7A:
undetectable		 5igjA-1ia7A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		4 / 8 LEU A 167
TRP A 219
THR A 163
ASN A 225
 None
 1.16A 6c71B-1ia7A:
undetectable		 6c71B-1ia7A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1ia7 CELLULASE CEL9M
([Clostridium]
cellulolyticum) 		3 / 3 TYR A 408
ASP A 402
GLN A 405
 None
 0.95A 6g1pA-1ia7A:
0.4		 6g1pA-1ia7A:
22.99