SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iap'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 1iap GUANINE NUCLEOTIDE
EXCHANGE FACTOR
P115RHOGEF
(Homo
sapiens) 		4 / 5 LEU A  76
MET A  60
LEU A  59
GLN A 153
 None
 1.45A 1p93D-1iapA:
undetectable		 1p93D-1iapA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 1iap GUANINE NUCLEOTIDE
EXCHANGE FACTOR
P115RHOGEF
(Homo
sapiens) 		4 / 6 TRP A 168
LEU A  59
LEU A  63
PRO A 167
 None
 1.19A 2dqyC-1iapA:
undetectable		 2dqyC-1iapA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1iap GUANINE NUCLEOTIDE
EXCHANGE FACTOR
P115RHOGEF
(Homo
sapiens) 		5 / 8 LEU A  62
ALA A  67
ILE A 222
GLY A  73
LEU A  59
 None
 1.40A 2o4nB-1iapA:
undetectable		 2o4nB-1iapA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1iap GUANINE NUCLEOTIDE
EXCHANGE FACTOR
P115RHOGEF
(Homo
sapiens) 		4 / 7 ALA A  57
PRO A  56
ARG A  54
ARG A 183
 None
 1.05A 3twpB-1iapA:
undetectable		 3twpB-1iapA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1iap GUANINE NUCLEOTIDE
EXCHANGE FACTOR
P115RHOGEF
(Homo
sapiens) 		4 / 7 ALA A  57
PRO A  56
ARG A  54
ARG A 183
 None
 1.11A 3twpC-1iapA:
undetectable		 3twpC-1iapA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1iap GUANINE NUCLEOTIDE
EXCHANGE FACTOR
P115RHOGEF
(Homo
sapiens) 		5 / 9 TYR A 225
PHE A 103
GLY A  73
LEU A  63
LEU A  59
 None
 1.42A 4ze0A-1iapA:
undetectable		 4ze0A-1iapA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1iap GUANINE NUCLEOTIDE
EXCHANGE FACTOR
P115RHOGEF
(Homo
sapiens) 		4 / 7 CYH A  77
HIS A 101
LEU A 104
ALA A 108
 None
 0.98A 5hrqE-1iapA:
undetectable
5hrqF-1iapA:
undetectable
5hrqJ-1iapA:
undetectable		 5hrqE-1iapA:
6.64
5hrqF-1iapA:
9.76
5hrqJ-1iapA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 1iap GUANINE NUCLEOTIDE
EXCHANGE FACTOR
P115RHOGEF
(Homo
sapiens) 		4 / 5 PHE A  46
VAL A 179
PRO A  56
VAL A  52
 None
 1.25A 6ekzA-1iapA:
0.0		 6ekzA-1iapA:
18.68