SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iaw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		3 / 3 THR A  32
LEU A  36
LEU A  43
 None
 0.61A 1mz9C-1iawA:
undetectable		 1mz9C-1iawA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 5 ASP A 123
THR A  39
LEU A  43
LEU A  40
 None
 1.20A 1u18B-1iawA:
0.0		 1u18B-1iawA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 7 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.84A 1usqA-1iawA:
0.0		 1usqA-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 6 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.82A 1usqB-1iawA:
undetectable		 1usqB-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 6 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.84A 1usqC-1iawA:
0.0		 1usqC-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 6 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.82A 1usqD-1iawA:
undetectable		 1usqD-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 6 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.82A 1usqE-1iawA:
0.0		 1usqE-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 7 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.81A 1usqF-1iawA:
undetectable		 1usqF-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		3 / 3 ARG A 215
VAL A 201
GLY A 235
 None
 0.62A 2avvE-1iawA:
undetectable		 2avvE-1iawA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 6 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.78A 2jkjA-1iawA:
0.0		 2jkjA-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 6 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.78A 2jkjB-1iawA:
0.0		 2jkjB-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 6 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.79A 2jkjC-1iawA:
0.0		 2jkjC-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 7 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.78A 2jkjE-1iawA:
undetectable		 2jkjE-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 7 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.82A 2jklA-1iawA:
undetectable		 2jklA-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 6 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.83A 2jklB-1iawA:
0.0		 2jklB-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 7 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.84A 2jklC-1iawA:
undetectable		 2jklC-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 7 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.82A 2jklD-1iawA:
0.0		 2jklD-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 7 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.83A 2jklE-1iawA:
undetectable		 2jklE-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 7 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.82A 2jklF-1iawA:
0.0		 2jklF-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 5 VAL A  92
VAL A  18
ARG A  17
LYS A 134
 None
 0.98A 3rv5A-1iawA:
0.4
3rv5B-1iawA:
undetectable		 3rv5A-1iawA:
14.92
3rv5B-1iawA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 8 VAL A 231
ILE A 248
SER A 239
ALA A 308
 None
 0.93A 4eyzA-1iawA:
0.0		 4eyzA-1iawA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 8 VAL A 231
ILE A 248
SER A 239
ALA A 308
 None
 0.94A 4eyzB-1iawA:
undetectable		 4eyzB-1iawA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		4 / 5 SER A 187
ALA A 188
PHE A 186
GLU A 203
 None
 1.07A 4m93B-1iawA:
undetectable
4m93C-1iawA:
undetectable		 4m93B-1iawA:
20.50
4m93C-1iawA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		3 / 3 VAL A  69
LEU A  73
VAL A  35
 None
 0.55A 4wq4A-1iawA:
undetectable		 4wq4A-1iawA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		3 / 3 ASP A  26
VAL A  35
LEU A  73
 None
 0.66A 5e5jB-1iawA:
0.0		 5e5jB-1iawA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		5 / 12 VAL A  35
PHE A  77
ILE A  89
VAL A  94
PHE A  79
 None
 1.32A 6ap6A-1iawA:
undetectable		 6ap6A-1iawA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1iaw TYPE II RESTRICTION
ENZYME NAEI
(Lechevalieria
aerocolonigenes) 		5 / 12 VAL A  35
PHE A  77
ILE A  89
VAL A  94
PHE A  79
 None
 1.32A 6ap6B-1iawA:
undetectable		 6ap6B-1iawA:
21.88