SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		5 / 12 ALA A 426
LEU A 350
LEU A 370
PRO A 372
ILE A 389
 None
 1.02A 1dhjB-1iayA:
undetectable		 1dhjB-1iayA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		5 / 11 ASN A 131
ALA A 130
GLY A 126
ARG A 110
PHE A 116
 PLP  A 500 ( 4.8A)
None
PLP  A 500 (-3.4A)
None
None
 1.16A 1l5rA-1iayA:
2.0		 1l5rA-1iayA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		4 / 8 LEU A 370
VAL A 413
LEU A 395
VAL A 393
 None
 0.97A 2bdmA-1iayA:
0.5		 2bdmA-1iayA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		6 / 12 ALA A 144
ASP A 143
ILE A 232
ILE A 203
ALA A 188
ILE A 168
 None
 1.48A 2nmzA-1iayA:
undetectable		 2nmzA-1iayA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		5 / 10 LEU A 322
LEU A 276
ILE A  63
PHE A 331
THR A 109
 None
 1.10A 3fl9E-1iayA:
undetectable		 3fl9E-1iayA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		5 / 12 GLY A 201
VAL A 235
ALA A 144
LEU A 159
ILE A 135
 None
 0.98A 3ku1H-1iayA:
2.6		 3ku1H-1iayA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		4 / 8 PHE A 250
SER A 252
LEU A 204
ASP A 237
 None
None
None
PLP  A 500 (-3.5A)
 1.06A 3m0wE-1iayA:
undetectable
3m0wF-1iayA:
undetectable
3m0wG-1iayA:
undetectable
3m0wH-1iayA:
undetectable		 3m0wE-1iayA:
11.03
3m0wF-1iayA:
11.03
3m0wG-1iayA:
11.03
3m0wH-1iayA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		5 / 12 GLY A 363
GLY A 212
PRO A 207
ALA A 241
ALA A 242
 None
 1.05A 3mteB-1iayA:
undetectable		 3mteB-1iayA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		5 / 12 TYR A 274
LEU A 318
PHE A 105
PHE A 317
PHE A 331
 None
 1.15A 3nuvA-1iayA:
0.0		 3nuvA-1iayA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		4 / 7 PHE A 365
ILE A 170
LEU A 215
ARG A 412
 None
None
None
AVG  A 501 (-3.6A)
 1.14A 3nxuA-1iayA:
0.0		 3nxuA-1iayA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		4 / 6 ASP A  61
ASP A 324
ASN A 330
GLU A 334
 None
 1.18A 3vywA-1iayA:
2.5		 3vywA-1iayA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		4 / 5 ASP A  61
ASP A 324
ASN A 330
GLU A 334
 None
 1.24A 3vywD-1iayA:
2.3		 3vywD-1iayA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		4 / 7 ILE A 253
LEU A 257
HIS A 271
VAL A 235
 None
 0.76A 4g77A-1iayA:
undetectable		 4g77A-1iayA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		5 / 12 VAL A 165
GLY A 129
ILE A 135
ILE A 203
LEU A 167
 None
 1.05A 4iv0A-1iayA:
3.6		 4iv0A-1iayA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		4 / 6 PHE A 411
LEU A 395
SER A 398
GLY A  52
 None
 1.10A 5o4yF-1iayA:
undetectable		 5o4yF-1iayA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		5 / 12 MET A 304
ALA A 130
VAL A 235
ASP A 143
PHE A 145
 None
 1.48A 5vlmD-1iayA:
0.0		 5vlmD-1iayA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		5 / 10 ILE A 102
LEU A 276
ALA A 242
LEU A 332
GLU A 255
 None
 1.15A 5y7pG-1iayA:
0.0		 5y7pG-1iayA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		5 / 12 ASN A 360
PHE A 365
PHE A 415
PHE A 245
ILE A 239
 None
None
None
None
PLP  A 500 (-4.6A)
 1.48A 6dwnB-1iayA:
0.0		 6dwnB-1iayA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2
(Solanum
lycopersicum) 		5 / 11 TYR A 274
THR A 109
GLU A 255
ALA A 362
ALA A 127
 None
None
None
None
PLP  A 500 (-2.9A)
 1.46A 6efnA-1iayA:
undetectable		 6efnA-1iayA:
22.41