SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ib1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ib1 SEROTONIN
N-ACETYLTRANSFERASE
(Ovis
aries) 		5 / 11 VAL E  48
SER E  81
LEU E  74
ILE E  94
ALA E 123
 None
None
None
None
COT  E 401 (-4.1A)
 0.99A 1eqgB-1ib1E:
undetectable		 1eqgB-1ib1E:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 1ib1 14-3-3 ZETA ISOFORM
(Homo
sapiens) 		5 / 11 TYR A 149
ASP A 124
PHE A 177
VAL A 142
ILE A 141
 None
 1.35A 1tcoC-1ib1A:
undetectable		 1tcoC-1ib1A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1ib1 14-3-3 ZETA ISOFORM
(Homo
sapiens) 		5 / 12 TRP A  59
ILE A 141
LEU A  98
SER A 145
ASP A  92
 None
 1.33A 2iyfB-1ib1A:
undetectable		 2iyfB-1ib1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1ib1 14-3-3 ZETA ISOFORM
(Homo
sapiens) 		5 / 10 TYR A 149
ASP A 124
PHE A 177
VAL A 142
ILE A 141
 None
 1.43A 2vn1B-1ib1A:
undetectable		 2vn1B-1ib1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1ib1 SEROTONIN
N-ACETYLTRANSFERASE
(Ovis
aries) 		4 / 6 PHE E 171
TYR E 168
VAL E 126
PHE E 167
 None
COT  E 401 (-4.8A)
COT  E 401 (-3.8A)
COT  E 401 (-3.6A)
 1.29A 3ltwA-1ib1E:
undetectable		 3ltwA-1ib1E:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 1ib1 14-3-3 ZETA ISOFORM
(Homo
sapiens) 		5 / 11 ARG A  56
LEU A  90
LEU A  98
GLY A 123
ASP A 124
 TPO  E  31 ( 3.0A)
None
None
None
None
 1.32A 3sfuC-1ib1A:
undetectable		 3sfuC-1ib1A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1ib1 14-3-3 ZETA ISOFORM
(Homo
sapiens) 		5 / 10 TYR A 149
ASP A 124
PHE A 177
VAL A 142
ILE A 141
 None
 1.40A 3uqaA-1ib1A:
undetectable		 3uqaA-1ib1A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 1ib1 SEROTONIN
N-ACETYLTRANSFERASE
(Ovis
aries) 		4 / 8 GLN E 150
HIS E 146
VAL E 147
VAL E 153
 None
 1.09A 3uy4A-1ib1E:
undetectable		 3uy4A-1ib1E:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1ib1 14-3-3 ZETA ISOFORM
SEROTONIN
N-ACETYLTRANSFERASE
(Homo
sapiens;
Ovis
aries) 		3 / 3 TYR A 211
HIS A 164
ARG E  89
 None
 0.98A 4e7bC-1ib1A:
0.3		 4e7bC-1ib1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 1ib1 14-3-3 ZETA ISOFORM
(Homo
sapiens) 		5 / 10 TYR A 149
ASP A 124
PHE A 177
VAL A 142
ILE A 141
 None
 1.48A 4laxA-1ib1A:
undetectable		 4laxA-1ib1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1ib1 SEROTONIN
N-ACETYLTRANSFERASE
(Ovis
aries) 		5 / 9 LEU E 144
ALA E 156
GLN E 169
PHE E 173
TYR E 168
 None
None
None
None
COT  E 401 (-4.8A)
 1.42A 4ltwA-1ib1E:
undetectable		 4ltwA-1ib1E:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 1ib1 SEROTONIN
N-ACETYLTRANSFERASE
(Ovis
aries) 		5 / 11 LEU E 164
VAL E 165
LEU E 140
GLY E 172
LEU E 158
 COT  E 401 (-4.6A)
None
None
None
COT  E 401 ( 4.8A)
 1.15A 4zbqA-1ib1E:
undetectable		 4zbqA-1ib1E:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ib1 14-3-3 ZETA ISOFORM
(Homo
sapiens) 		5 / 9 SER A 156
ALA A 152
ALA A 148
GLY A 169
ASP A 124
 None
 0.96A 5d0xK-1ib1A:
undetectable
5d0xL-1ib1A:
undetectable		 5d0xK-1ib1A:
22.76
5d0xL-1ib1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ib1 14-3-3 ZETA ISOFORM
(Homo
sapiens) 		5 / 9 SER A 156
ALA A 152
ALA A 148
GLY A 169
ASP A 124
 None
 0.94A 5d0xY-1ib1A:
undetectable
5d0xZ-1ib1A:
undetectable		 5d0xY-1ib1A:
22.76
5d0xZ-1ib1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1ib1 SEROTONIN
N-ACETYLTRANSFERASE
(Ovis
aries) 		4 / 6 LEU E 104
CYH E 193
HIS E 120
LEU E 121
 None
 1.35A 5hrqD-1ib1E:
undetectable
5hrqG-1ib1E:
undetectable
5hrqH-1ib1E:
undetectable		 5hrqD-1ib1E:
12.58
5hrqG-1ib1E:
7.95
5hrqH-1ib1E:
12.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1ib1 14-3-3 ZETA ISOFORM
(Homo
sapiens) 		4 / 5 PHE A 196
ILE A 200
MET A 218
GLN A 219
 None
 1.00A 5jm4A-1ib1A:
32.5		 5jm4A-1ib1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1ib1 SEROTONIN
N-ACETYLTRANSFERASE
(Ovis
aries) 		3 / 3 ARG E  28
ILE E  20
SER E  18
 TPO  E  31 ( 4.8A)
None
None
 0.81A 5zw2A-1ib1E:
undetectable		 5zw2A-1ib1E:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1ib1 SEROTONIN
N-ACETYLTRANSFERASE
(Ovis
aries) 		4 / 5 GLY E 116
ASP E 100
ARG E 115
ARG E 113
 None
 1.36A 6dwdB-1ib1E:
0.0
6dwdD-1ib1E:
0.0		 6dwdB-1ib1E:
18.48
6dwdD-1ib1E:
18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 1ib1 14-3-3 ZETA ISOFORM
SEROTONIN
N-ACETYLTRANSFERASE
(Homo
sapiens;
Ovis
aries) 		4 / 5 SER A  45
VAL A  46
ASN A  50
PRO E  33
 None
None
None
TPO  E  31 ( 4.0A)
 0.46A 6fi4A-1ib1A:
30.8
6fi4B-1ib1A:
undetectable		 6fi4A-1ib1A:
72.65
6fi4B-1ib1A:
3.03