SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ic8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 1ic8 HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Homo
sapiens) 		4 / 5 PRO A 129
LEU A 123
THR A 164
ARG A 168
 None
 1.39A 1i2wA-1ic8A:
undetectable		 1i2wA-1ic8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 1ic8 HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Homo
sapiens) 		3 / 3 TRP A 165
GLN A 157
THR A 164
 None
 0.87A 4m2xA-1ic8A:
undetectable		 4m2xA-1ic8A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1ic8 HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Homo
sapiens) 		5 / 10 VAL A 259
GLU A 240
VAL A 264
SER A 210
LEU A 214
 None
 1.07A 4yb6A-1ic8A:
undetectable
4yb6E-1ic8A:
0.0		 4yb6A-1ic8A:
20.75
4yb6E-1ic8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1ic8 HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Homo
sapiens) 		5 / 10 VAL A 259
GLU A 240
VAL A 264
SER A 210
LEU A 214
 None
 1.06A 4yb6B-1ic8A:
0.0
4yb6C-1ic8A:
0.0		 4yb6B-1ic8A:
20.75
4yb6C-1ic8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1ic8 HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Homo
sapiens) 		5 / 10 VAL A 259
GLU A 240
VAL A 264
SER A 210
LEU A 214
 None
 1.07A 4yb6C-1ic8A:
undetectable
4yb6F-1ic8A:
undetectable		 4yb6C-1ic8A:
20.75
4yb6F-1ic8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1ic8 HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Homo
sapiens) 		5 / 10 SER A 210
LEU A 214
VAL A 259
GLU A 240
VAL A 264
 None
 1.04A 4yb6A-1ic8A:
undetectable
4yb6D-1ic8A:
undetectable		 4yb6A-1ic8A:
20.75
4yb6D-1ic8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1ic8 HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Homo
sapiens) 		5 / 10 SER A 210
LEU A 214
VAL A 259
GLU A 240
VAL A 264
 None
 1.08A 4yb6D-1ic8A:
0.0
4yb6E-1ic8A:
0.0		 4yb6D-1ic8A:
20.75
4yb6E-1ic8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1ic8 HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Homo
sapiens) 		5 / 10 SER A 210
LEU A 214
VAL A 259
GLU A 240
VAL A 264
 None
 1.09A 4yb6B-1ic8A:
0.0
4yb6F-1ic8A:
0.0		 4yb6B-1ic8A:
20.75
4yb6F-1ic8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1ic8 HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Homo
sapiens) 		4 / 4 GLY A 255
ARG A 244
ASN A 257
LEU A 258
 None
 1.41A 6b58A-1ic8A:
0.1		 6b58A-1ic8A:
16.09