SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1icf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 1icf PROTEIN (CATHEPSIN
L: HEAVY CHAIN)
(Homo
sapiens) 		3 / 3 ALA A  33
VAL A 168
TRP A   7
 None
 1.01A 1c4dA-1icfA:
undetectable
1c4dB-1icfA:
undetectable		 1c4dA-1icfA:
4.68
1c4dB-1icfA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 1icf PROTEIN (CATHEPSIN
L: HEAVY CHAIN)
(Homo
sapiens) 		4 / 7 LEU A  53
THR A  31
LEU A  34
VAL A 106
 None
 0.97A 1jgsA-1icfA:
0.0		 1jgsA-1icfA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 1icf PROTEIN (CATHEPSIN
L: HEAVY CHAIN)
(Homo
sapiens) 		4 / 6 ASN A 108
GLY A  81
PRO A 102
SER A 105
 None
 0.85A 1n4fA-1icfA:
undetectable		 1n4fA-1icfA:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1icf PROTEIN (CATHEPSIN
L: HEAVY CHAIN)
PROTEIN (INVARIANT
CHAIN)
(Homo
sapiens;
Homo
sapiens) 		8 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 163
GLY I 210
 None
 0.37A 1stfE-1icfA:
23.7
1stfI-1icfA:
undetectable		 1stfE-1icfA:
36.67
1stfI-1icfA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1icf PROTEIN (CATHEPSIN
L: HEAVY CHAIN)
(Homo
sapiens) 		3 / 3 LYS A   1
TYR A 170
PRO A   2
 None
 1.10A 2j9cC-1icfA:
0.2		 2j9cC-1icfA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1icf PROTEIN (CATHEPSIN
L: HEAVY CHAIN)
(Homo
sapiens) 		4 / 7 THR A  14
PRO A  15
VAL A  16
GLU A  50
 None
 1.06A 2v2gA-1icfA:
undetectable
2v2gB-1icfA:
undetectable		 2v2gA-1icfA:
22.78
2v2gB-1icfA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1icf PROTEIN (CATHEPSIN
L: HEAVY CHAIN)
(Homo
sapiens) 		4 / 7 THR A  14
PRO A  15
VAL A  16
GLU A  50
 None
 1.07A 2v2gC-1icfA:
undetectable
2v2gD-1icfA:
undetectable		 2v2gC-1icfA:
22.78
2v2gD-1icfA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 1icf PROTEIN (CATHEPSIN
L: HEAVY CHAIN)
(Homo
sapiens) 		4 / 7 THR A  14
PRO A  15
VAL A  16
GLU A  50
 None
 1.07A 2v41E-1icfA:
undetectable
2v41F-1icfA:
undetectable		 2v41E-1icfA:
22.78
2v41F-1icfA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 1icf PROTEIN (CATHEPSIN
L: HEAVY CHAIN)
PROTEIN (INVARIANT
CHAIN)
(Homo
sapiens) 		4 / 8 HIS A 140
PHE A 143
ASP A 162
GLY I 229
 None
 0.90A 3c0zB-1icfA:
undetectable		 3c0zB-1icfA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 1icf PROTEIN (INVARIANT
CHAIN)
(Homo
sapiens) 		3 / 3 PRO I 239
SER I 258
ASN I 221
 None
 0.90A 3lslG-1icfI:
undetectable		 3lslG-1icfI:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 1icf PROTEIN (CATHEPSIN
L: HEAVY CHAIN)
(Homo
sapiens) 		3 / 3 LEU A  69
ASP A  71
TYR A  72
 None
 0.55A 4qc6B-1icfA:
0.0		 4qc6B-1icfA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1icf PROTEIN (CATHEPSIN
L: HEAVY CHAIN)
PROTEIN (INVARIANT
CHAIN)
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY A  68
HIS A 163
TYR I 228
GLN A  19
ILE I 231
 None
 1.44A 4ynmA-1icfA:
undetectable		 4ynmA-1icfA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 1icf PROTEIN (CATHEPSIN
L: HEAVY CHAIN)
PROTEIN (INVARIANT
CHAIN)
(Homo
sapiens) 		3 / 3 GLY A  20
ASN A  18
ARG I 250
 None
 0.70A 5w7bD-1icfA:
undetectable		 5w7bD-1icfA:
20.95