SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1id0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		5 / 9 ASN A 389
ASP A 415
ILE A 420
PRO A 421
ILE A 428
 ANP  A 487 (-3.0A)
ANP  A 487 (-3.7A)
ANP  A 487 (-4.7A)
None
ANP  A 487 (-3.7A)
 0.70A 1aj6A-1id0A:
6.3		 1aj6A-1id0A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		5 / 12 ASN A 389
ASP A 415
ILE A 420
PRO A 421
ILE A 428
 ANP  A 487 (-3.0A)
ANP  A 487 (-3.7A)
ANP  A 487 (-4.7A)
None
ANP  A 487 (-3.7A)
 0.78A 1kijB-1id0A:
6.6		 1kijB-1id0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		4 / 7 ALA A 470
ASP A 415
GLY A 469
GLY A 419
 ANP  A 487 (-3.5A)
ANP  A 487 (-3.7A)
None
ANP  A 487 (-4.3A)
 0.78A 2c49B-1id0A:
undetectable		 2c49B-1id0A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		4 / 5 VAL A 413
VAL A 412
THR A 348
ARG A 471
 None
 1.12A 3bjwA-1id0A:
0.0		 3bjwA-1id0A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		4 / 5 VAL A 413
VAL A 412
THR A 348
ARG A 471
 None
 1.08A 3bjwC-1id0A:
0.3		 3bjwC-1id0A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		5 / 10 ILE A 420
GLY A 419
GLY A 469
LEU A 467
VAL A 412
 ANP  A 487 (-4.7A)
ANP  A 487 (-4.3A)
None
None
None
 1.02A 3em4V-1id0A:
undetectable		 3em4V-1id0A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		5 / 12 ASN A 385
GLY A 445
ARG A 431
ASP A 388
VAL A 354
 MG  A 700 ( 2.7A)
ANP  A 487 (-3.4A)
None
None
None
 1.21A 3k13A-1id0A:
undetectable		 3k13A-1id0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		5 / 12 ASN A 385
GLY A 445
ARG A 431
ASP A 388
VAL A 354
 MG  A 700 ( 2.7A)
ANP  A 487 (-3.4A)
None
None
None
 1.26A 3k13B-1id0A:
undetectable		 3k13B-1id0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		5 / 12 ASN A 385
GLY A 445
ARG A 431
ASP A 388
VAL A 354
 MG  A 700 ( 2.7A)
ANP  A 487 (-3.4A)
None
None
None
 1.26A 3k13C-1id0A:
undetectable		 3k13C-1id0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		5 / 12 ASN A 389
ASP A 415
ILE A 420
PRO A 421
ILE A 428
 ANP  A 487 (-3.0A)
ANP  A 487 (-3.7A)
ANP  A 487 (-4.7A)
None
ANP  A 487 (-3.7A)
 0.73A 4uroA-1id0A:
6.0		 4uroA-1id0A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		5 / 12 ASN A 389
ASP A 415
ILE A 420
PRO A 421
ILE A 428
 ANP  A 487 (-3.0A)
ANP  A 487 (-3.7A)
ANP  A 487 (-4.7A)
None
ANP  A 487 (-3.7A)
 0.83A 4uroB-1id0A:
5.9		 4uroB-1id0A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		5 / 12 ASN A 389
ASP A 415
ILE A 420
PRO A 421
ILE A 428
 ANP  A 487 (-3.0A)
ANP  A 487 (-3.7A)
ANP  A 487 (-4.7A)
None
ANP  A 487 (-3.7A)
 0.60A 4uroC-1id0A:
5.9		 4uroC-1id0A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		5 / 12 ASN A 389
ASP A 415
ILE A 420
PRO A 421
ILE A 428
 ANP  A 487 (-3.0A)
ANP  A 487 (-3.7A)
ANP  A 487 (-4.7A)
None
ANP  A 487 (-3.7A)
 0.77A 4uroD-1id0A:
6.0		 4uroD-1id0A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		5 / 10 ILE A 411
ILE A 400
VAL A 474
ASN A 389
ASP A 415
 None
None
None
ANP  A 487 (-3.0A)
ANP  A 487 (-3.7A)
 1.27A 5lg3F-1id0A:
0.0		 5lg3F-1id0A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		5 / 10 ILE A 411
ILE A 400
VAL A 474
ASN A 389
ASP A 415
 None
None
None
ANP  A 487 (-3.0A)
ANP  A 487 (-3.7A)
 1.26A 5lg3G-1id0A:
0.0		 5lg3G-1id0A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		5 / 10 ILE A 411
ILE A 400
VAL A 474
ASN A 389
ASP A 415
 None
None
None
ANP  A 487 (-3.0A)
ANP  A 487 (-3.7A)
 1.25A 5lg3H-1id0A:
0.0		 5lg3H-1id0A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		5 / 11 GLY A 443
ASN A 389
TYR A 393
TYR A 355
LEU A 351
 MG  A 700 ( 4.4A)
ANP  A 487 (-3.0A)
ANP  A 487 (-4.0A)
None
None
 1.17A 5updA-1id0A:
0.0		 5updA-1id0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 1id0 PHOQ HISTIDINE
KINASE
(Escherichia
coli) 		5 / 11 GLY A 443
ASN A 389
TYR A 393
TYR A 355
LEU A 351
 MG  A 700 ( 4.4A)
ANP  A 487 (-3.0A)
ANP  A 487 (-4.0A)
None
None
 1.19A 6cenA-1id0A:
0.0		 6cenA-1id0A:
21.21