SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1idm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 ALA A 292
MET A   1
LEU A  32
GLU A  30
GLU A 304
 None
 1.50A 1a29A-1idmA:
undetectable		 1a29A-1idmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 TRP A 193
ALA A 184
VAL A 189
 None
 0.94A 1bdwA-1idmA:
undetectable
1bdwB-1idmA:
undetectable		 1bdwA-1idmA:
5.95
1bdwB-1idmA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A 317
THR A 337
VAL A 338
ALA A 329
 None
 0.87A 1fiqC-1idmA:
1.0		 1fiqC-1idmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ARG A 175
ARG A 227
ARG A 174
 None
 1.05A 1l7fA-1idmA:
undetectable		 1l7fA-1idmA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ARG A 175
ARG A 227
ARG A 174
 None
 1.06A 1l7hA-1idmA:
undetectable		 1l7hA-1idmA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 LEU A 290
VAL A 313
HIS A 298
GLU A 297
LEU A 127
 None
 1.25A 1mrqA-1idmA:
undetectable		 1mrqA-1idmA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 LEU A 290
GLY A 253
LEU A 110
LEU A 317
PHE A 107
 None
 1.08A 1nr6A-1idmA:
undetectable		 1nr6A-1idmA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A  10
GLY A  12
ILE A 277
ALA A 283
ASP A 276
 None
 1.21A 1ri4A-1idmA:
undetectable		 1ri4A-1idmA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 ARG A 102
GLU A 268
PRO A 269
ALA A 287
 None
 1.47A 2ejgB-1idmA:
undetectable		 2ejgB-1idmA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 LEU A  23
ILE A 289
VAL A 309
ALA A 292
 None
 0.91A 2j5mA-1idmA:
0.0		 2j5mA-1idmA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A 296
VAL A 338
LEU A 342
VAL A 313
 None
 0.83A 2zujA-1idmA:
undetectable		 2zujA-1idmA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A 317
THR A 337
VAL A 338
ALA A 329
 None
 0.90A 3ax9A-1idmA:
2.9		 3ax9A-1idmA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 GLU A 198
SER A 180
VAL A 232
 None
 0.65A 3eeoA-1idmA:
2.1		 3eeoA-1idmA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 GLY A  42
GLY A  87
THR A  57
ALA A  45
 None
 0.87A 3fpjB-1idmA:
undetectable		 3fpjB-1idmA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 GLY A 250
ALA A 121
SER A 114
GLU A 111
 None
 0.90A 3u9hA-1idmA:
undetectable		 3u9hA-1idmA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A 317
THR A 337
VAL A 338
ALA A 329
 None
 0.95A 3uniB-1idmA:
3.7		 3uniB-1idmA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 LEU A  69
PHE A 267
LEU A  91
PHE A  53
 None
 0.96A 3wg7P-1idmA:
undetectable
3wg7W-1idmA:
0.0		 3wg7P-1idmA:
18.75
3wg7W-1idmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 ASP A 243
ASN A 100
GLU A 268
ASP A 239
 None
 1.20A 4fevB-1idmA:
undetectable		 4fevB-1idmA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 THR A 335
LEU A  68
LYS A   1
LEU A 296
 None
 0.96A 4ib4A-1idmA:
1.2		 4ib4A-1idmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 SER A 259
SER A 257
LEU A   6
LEU A  69
 None
 0.91A 4ikjA-1idmA:
undetectable
4ikjB-1idmA:
undetectable		 4ikjA-1idmA:
18.08
4ikjB-1idmA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A   6
LEU A  69
SER A 259
SER A 257
 None
 0.92A 4ikkA-1idmA:
undetectable
4ikkB-1idmA:
undetectable		 4ikkA-1idmA:
18.08
4ikkB-1idmA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 SER A 259
SER A 257
LEU A   6
LEU A  69
 None
 0.92A 4iklA-1idmA:
undetectable
4iklB-1idmA:
undetectable		 4iklA-1idmA:
18.08
4iklB-1idmA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A 290
VAL A 313
HIS A 298
LEU A 127
 None
 0.81A 4l1xA-1idmA:
0.1		 4l1xA-1idmA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A  26
LEU A  23
VAL A  22
ILE A 289
 None
 0.95A 4oj4A-1idmA:
0.0		 4oj4A-1idmA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 LEU A  32
LEU A 290
LYS A   1
GLU A  65
VAL A 309
VAL A 338
 None
 1.42A 4y0qA-1idmA:
0.0		 4y0qA-1idmA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ARG A  92
ASN A 100
ASP A 243
 None
 0.73A 5gwxA-1idmA:
undetectable		 5gwxA-1idmA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A 316
PRO A 285
PHE A 334
GLY A 330
GLU A 332
 None
 1.15A 5hfjC-1idmA:
undetectable		 5hfjC-1idmA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 VAL A   3
GLU A  65
ALA A  66
LEU A  34
 None
 0.44A 5jq7A-1idmA:
0.0		 5jq7A-1idmA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 TYR A 137
ILE A 136
LEU A 241
GLY A 238
 None
 0.85A 5kmdC-1idmA:
undetectable
5kmdD-1idmA:
undetectable		 5kmdC-1idmA:
22.47
5kmdD-1idmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 PHE A 237
GLY A 238
VAL A 126
ALA A 218
LEU A 221
 None
 1.11A 5kocA-1idmA:
undetectable		 5kocA-1idmA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 236
VAL A 230
LEU A 127
ARG A 130
LEU A 260
 None
 1.07A 6a7pB-1idmA:
undetectable		 6a7pB-1idmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 HIS A 298
VAL A 129
LEU A 101
ALA A 170
 None
 1.37A 6d8pB-1idmA:
2.9		 6d8pB-1idmA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1idm 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 HIS A 271
ALA A 288
GLY A  12
SER A  71
ALA A 274
 None
 1.34A 6ieyA-1idmA:
undetectable
6ieyB-1idmA:
undetectable		 6ieyA-1idmA:
23.68
6ieyB-1idmA:
23.68