SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1idt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		3 / 4 VAL A 143
TRP A 138
TRP A  46
 None
 1.23A 1gmkA-1idtA:
undetectable
1gmkB-1idtA:
undetectable		 1gmkA-1idtA:
7.91
1gmkB-1idtA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		3 / 3 ASP A  92
LEU A  95
HIS A 133
 None
 0.72A 1qknA-1idtA:
0.0		 1qknA-1idtA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		5 / 12 GLY A  66
ALA A  65
GLY A 166
ALA A 170
ILE A 171
 None
None
FMN  A1218 (-3.6A)
None
None
 0.91A 1rl8A-1idtA:
undetectable		 1rl8A-1idtA:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		5 / 8 TYR A  68
ASN A  71
LYS A  74
GLU A 165
GLY A 166
 None
FMN  A1218 (-3.4A)
FMN  A1218 (-2.7A)
FMN  A1218 (-3.5A)
FMN  A1218 (-3.6A)
 0.67A 1ykiA-1idtA:
34.0
1ykiB-1idtA:
34.1		 1ykiA-1idtA:
100.00
1ykiB-1idtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		5 / 8 TYR A  68
ASN A  71
LYS A  74
GLU A 165
GLY A 166
 None
FMN  A1218 (-3.4A)
FMN  A1218 (-2.7A)
FMN  A1218 (-3.5A)
FMN  A1218 (-3.6A)
 0.69A 1ykiA-1idtA:
34.0
1ykiB-1idtA:
34.1		 1ykiA-1idtA:
100.00
1ykiB-1idtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		5 / 8 TYR A  68
ASN A  71
LYS A  74
GLU A 165
GLY A 166
 None
FMN  A1218 (-3.4A)
FMN  A1218 (-2.7A)
FMN  A1218 (-3.5A)
FMN  A1218 (-3.6A)
 0.68A 1ykiC-1idtA:
34.1
1ykiD-1idtA:
34.1		 1ykiC-1idtA:
100.00
1ykiD-1idtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		5 / 8 TYR A  68
ASN A  71
LYS A  74
GLU A 165
GLY A 166
 None
FMN  A1218 (-3.4A)
FMN  A1218 (-2.7A)
FMN  A1218 (-3.5A)
FMN  A1218 (-3.6A)
 0.65A 1ykiC-1idtA:
34.1
1ykiD-1idtA:
34.1		 1ykiC-1idtA:
100.00
1ykiD-1idtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		5 / 12 GLY A  66
ALA A  65
GLY A 166
ALA A 170
ILE A 171
 None
None
FMN  A1218 (-3.6A)
None
None
 0.87A 2b60A-1idtA:
undetectable		 2b60A-1idtA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		5 / 11 GLY A  66
ALA A  65
GLY A 166
ALA A 170
ILE A 171
 None
None
FMN  A1218 (-3.6A)
None
None
 0.88A 2b60B-1idtA:
undetectable		 2b60B-1idtA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		5 / 12 GLY A  66
ALA A  65
GLY A 166
ALA A 170
ILE A 171
 None
None
FMN  A1218 (-3.6A)
None
None
 0.90A 2rkfA-1idtA:
undetectable		 2rkfA-1idtA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		5 / 12 GLY A  66
ALA A  65
GLY A 166
ALA A 170
ILE A 171
 None
None
FMN  A1218 (-3.6A)
None
None
 0.88A 2rkfB-1idtA:
undetectable		 2rkfB-1idtA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		5 / 11 LEU A 157
VAL A 154
LYS A   9
VAL A   6
HIS A 193
 None
 1.06A 2yy8A-1idtA:
undetectable
2yy8B-1idtA:
undetectable		 2yy8A-1idtA:
26.72
2yy8B-1idtA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		5 / 9 ASP A 160
ILE A  30
GLY A 153
PRO A 163
VAL A 162
 None
None
None
FMN  A1218 (-4.1A)
None
 1.30A 3ekyB-1idtA:
undetectable		 3ekyB-1idtA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		4 / 8 ASP A  91
ASP A  92
ASP A 134
TRP A 138
 None
 1.23A 3havA-1idtA:
0.8		 3havA-1idtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		3 / 3 LEU A 132
HIS A 128
MET A 127
 None
 0.96A 3thrD-1idtA:
undetectable		 3thrD-1idtA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1idt MINOR FMN-DEPENDENT
NITROREDUCTASE
(Escherichia
coli) 		4 / 5 SER A  79
ALA A  78
HIS A  80
LEU A 159
 None
 1.41A 5dzkf-1idtA:
0.0
5dzkt-1idtA:
undetectable		 5dzkf-1idtA:
24.19
5dzkt-1idtA:
1.32