SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ifw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ifw POLYADENYLATE-BINDIN
G PROTEIN,
CYTOPLASMIC AND
NUCLEAR
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  34
SER A  63
THR A  46
ILE A  49
LEU A  60
 None
 1.02A 1qzfA-1ifwA:
undetectable		 1qzfA-1ifwA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ifw POLYADENYLATE-BINDIN
G PROTEIN,
CYTOPLASMIC AND
NUCLEAR
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  34
SER A  63
THR A  46
ILE A  49
LEU A  60
 None
 1.02A 1qzfB-1ifwA:
undetectable		 1qzfB-1ifwA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ifw POLYADENYLATE-BINDIN
G PROTEIN,
CYTOPLASMIC AND
NUCLEAR
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  34
SER A  63
THR A  46
ILE A  49
LEU A  60
 None
 1.02A 1qzfC-1ifwA:
undetectable		 1qzfC-1ifwA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ifw POLYADENYLATE-BINDIN
G PROTEIN,
CYTOPLASMIC AND
NUCLEAR
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  34
SER A  63
THR A  46
ILE A  49
LEU A  60
 None
 1.02A 1qzfD-1ifwA:
undetectable		 1qzfD-1ifwA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ifw POLYADENYLATE-BINDIN
G PROTEIN,
CYTOPLASMIC AND
NUCLEAR
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  34
SER A  63
THR A  46
ILE A  49
LEU A  60
 None
 1.03A 1qzfE-1ifwA:
undetectable		 1qzfE-1ifwA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1ifw POLYADENYLATE-BINDIN
G PROTEIN,
CYTOPLASMIC AND
NUCLEAR
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  34
SER A  63
THR A  46
ILE A  49
LEU A  60
 None
 1.01A 2oipA-1ifwA:
undetectable		 2oipA-1ifwA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1ifw POLYADENYLATE-BINDIN
G PROTEIN,
CYTOPLASMIC AND
NUCLEAR
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  34
SER A  63
THR A  46
ILE A  49
LEU A  60
 None
 0.94A 2oipD-1ifwA:
undetectable		 2oipD-1ifwA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1ifw POLYADENYLATE-BINDIN
G PROTEIN,
CYTOPLASMIC AND
NUCLEAR
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  34
SER A  63
THR A  46
ILE A  49
LEU A  60
 None
 0.99A 2oipE-1ifwA:
undetectable		 2oipE-1ifwA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1ifw POLYADENYLATE-BINDIN
G PROTEIN,
CYTOPLASMIC AND
NUCLEAR
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  34
SER A  63
THR A  46
ILE A  49
LEU A  60
 None
 1.06A 3hj3A-1ifwA:
undetectable		 3hj3A-1ifwA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1ifw POLYADENYLATE-BINDIN
G PROTEIN,
CYTOPLASMIC AND
NUCLEAR
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  34
SER A  63
THR A  46
ILE A  49
LEU A  60
 None
 0.98A 3hj3B-1ifwA:
undetectable		 3hj3B-1ifwA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1ifw POLYADENYLATE-BINDIN
G PROTEIN,
CYTOPLASMIC AND
NUCLEAR
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  34
SER A  63
THR A  46
ILE A  49
LEU A  60
 None
 1.02A 3hj3D-1ifwA:
undetectable		 3hj3D-1ifwA:
10.58