SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ig0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 270
SER A 285
SER A 287
ASN A 288
 None
 0.17A 1ig3A-1ig0A:
25.7
1ig3B-1ig0A:
26.0		 1ig3A-1ig0A:
31.36
1ig3B-1ig0A:
31.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		4 / 7 TRP A 270
SER A 285
SER A 287
ASN A 288
 None
 0.19A 1ig3A-1ig0A:
25.7
1ig3B-1ig0A:
26.0		 1ig3A-1ig0A:
31.36
1ig3B-1ig0A:
31.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 191
ILE A  43
LEU A 189
ASP A 126
 None
 0.93A 1jg4A-1ig0A:
undetectable		 1jg4A-1ig0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 117
ASP A  69
LEU A  98
GLY A  96
ALA A  72
 None
 1.38A 1ju6A-1ig0A:
0.0		 1ju6A-1ig0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 117
ASP A  69
LEU A  98
GLY A  96
ALA A  72
 None
 1.38A 1ju6C-1ig0A:
0.0		 1ju6C-1ig0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 117
ASP A  69
LEU A  98
GLY A  96
ALA A  72
 None
 1.38A 1ju6D-1ig0A:
0.0		 1ju6D-1ig0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 131
LEU A 209
SER A 210
LEU A 229
THR A 128
 None
 1.37A 1kw0A-1ig0A:
undetectable		 1kw0A-1ig0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  64
VAL A  66
CYH A  67
ALA A  72
 None
 1.20A 1mz9E-1ig0A:
0.0		 1mz9E-1ig0A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 117
ILE A 147
PHE A 143
VAL A  66
LEU A  64
 None
 1.00A 1qhsA-1ig0A:
undetectable		 1qhsA-1ig0A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 117
ILE A 147
PHE A 143
VAL A  66
LEU A  64
 None
 1.07A 1qhyA-1ig0A:
undetectable		 1qhyA-1ig0A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 207
GLU A 258
THR A 300
 None
 1.03A 2y7hB-1ig0A:
2.2		 2y7hB-1ig0A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		5 / 8 ASN A 307
GLY A 252
GLY A 249
ILE A 248
THR A 224
 None
 1.18A 3so9A-1ig0A:
undetectable		 3so9A-1ig0A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 158
ASN A 156
PHE A 143
ILE A 147
 None
 0.97A 4j4vC-1ig0A:
undetectable		 4j4vC-1ig0A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 109
ALA A  71
GLY A  70
ILE A  48
GLY A 190
 None
 1.02A 4obwA-1ig0A:
2.3		 4obwA-1ig0A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 109
ALA A  71
GLY A  70
ILE A  48
GLY A 190
 None
 0.95A 4obwD-1ig0A:
undetectable		 4obwD-1ig0A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 202
GLY A 190
GLY A 191
PHE A 127
GLN A 198
 None
None
None
None
VIB  A 702 ( 4.5A)
 1.30A 4ubeA-1ig0A:
undetectable		 4ubeA-1ig0A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		5 / 6 ASP A 271
THR A 277
PRO A 255
THR A 260
VAL A 262
 None
 1.49A 4yoaA-1ig0A:
undetectable		 4yoaA-1ig0A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		4 / 7 THR A 208
LEU A 209
THR A 204
THR A 128
 None
 0.94A 4z90A-1ig0A:
0.0
4z90B-1ig0A:
0.0
4z90C-1ig0A:
0.0
4z90D-1ig0A:
0.0
4z90E-1ig0A:
0.0		 4z90A-1ig0A:
22.02
4z90B-1ig0A:
22.02
4z90C-1ig0A:
22.02
4z90D-1ig0A:
22.02
4z90E-1ig0A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		4 / 7 THR A 128
THR A 208
LEU A 209
THR A 204
 None
 0.89A 4z91F-1ig0A:
0.0
4z91G-1ig0A:
0.0
4z91H-1ig0A:
0.0
4z91I-1ig0A:
0.0
4z91J-1ig0A:
0.0		 4z91F-1ig0A:
22.02
4z91G-1ig0A:
22.02
4z91H-1ig0A:
22.02
4z91I-1ig0A:
22.02
4z91J-1ig0A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		4 / 7 THR A 208
LEU A 209
THR A 204
THR A 128
 None
 0.88A 4z91F-1ig0A:
0.0
4z91G-1ig0A:
0.0
4z91H-1ig0A:
0.0
4z91I-1ig0A:
0.0
4z91J-1ig0A:
0.0		 4z91F-1ig0A:
22.02
4z91G-1ig0A:
22.02
4z91H-1ig0A:
22.02
4z91I-1ig0A:
22.02
4z91J-1ig0A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 117
ASP A  69
LEU A  98
GLY A  96
ALA A  72
 None
 1.35A 5fctA-1ig0A:
0.0		 5fctA-1ig0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1ig0 THIAMIN
PYROPHOSPHOKINASE
(Saccharomyces
cerevisiae) 		5 / 8 ILE A 134
VAL A 131
VAL A 200
ILE A 192
ILE A 227
 None
 1.16A 5hi2A-1ig0A:
undetectable		 5hi2A-1ig0A:
19.55