SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ig8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 267
ALA A 239
GLY A 238
TYR A 240
 None
 1.14A 1c8lA-1ig8A:
0.9		 1c8lA-1ig8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 273
LEU A 395
VAL A  36
VAL A 279
 None
 1.08A 1e7aB-1ig8A:
0.4		 1e7aB-1ig8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 267
ALA A 239
GLY A 238
TYR A 240
 None
 1.11A 1gfzA-1ig8A:
undetectable		 1gfzA-1ig8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 9 VAL A 217
GLY A 463
THR A 156
ILE A 467
SER A 158
 None
 1.34A 1gtnL-1ig8A:
undetectable
1gtnM-1ig8A:
undetectable		 1gtnL-1ig8A:
8.75
1gtnM-1ig8A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 267
ALA A 239
GLY A 238
TYR A 240
 None
 1.09A 1l5qA-1ig8A:
undetectable		 1l5qA-1ig8A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 267
ALA A 239
GLY A 238
TYR A 240
 None
 1.10A 1l5qB-1ig8A:
2.8		 1l5qB-1ig8A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 267
ALA A 239
GLY A 238
TYR A 240
 None
 1.10A 1l7xA-1ig8A:
undetectable		 1l7xA-1ig8A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 267
ALA A 239
GLY A 238
TYR A 240
 None
 1.09A 1l7xB-1ig8A:
undetectable		 1l7xB-1ig8A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 8 ASP A 417
GLY A 235
SER A 158
ASP A  86
THR A 156
 None
 1.31A 1m4iA-1ig8A:
0.0		 1m4iA-1ig8A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_B_KANB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 417
GLY A 235
SER A 158
ASP A  86
THR A 156
 None
 1.41A 1m4iB-1ig8A:
0.0		 1m4iB-1ig8A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 270
GLY A 238
TYR A 240
ILE A 403
ALA A 402
 None
 1.29A 1mrgA-1ig8A:
undetectable		 1mrgA-1ig8A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 416
GLY A 233
SER A 396
 None
SO4  A 501 ( 3.7A)
None
 0.59A 2ivuA-1ig8A:
undetectable		 2ivuA-1ig8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  41
GLY A 399
ALA A 401
ILE A 453
ILE A 438
 None
 0.87A 2q63A-1ig8A:
undetectable		 2q63A-1ig8A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 143
ILE A 203
PRO A 202
VAL A  94
TYR A 112
 None
 1.17A 2w3aA-1ig8A:
undetectable		 2w3aA-1ig8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 414
TYR A 270
VAL A 397
CYH A 404
 None
 1.28A 2xz5A-1ig8A:
0.0
2xz5C-1ig8A:
0.0		 2xz5A-1ig8A:
21.68
2xz5C-1ig8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 414
TYR A 270
VAL A 397
CYH A 404
 None
 1.29A 2xz5C-1ig8A:
0.0
2xz5D-1ig8A:
undetectable		 2xz5C-1ig8A:
21.68
2xz5D-1ig8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 414
TYR A 270
VAL A 397
CYH A 404
 None
 1.29A 2xz5D-1ig8A:
0.0
2xz5E-1ig8A:
0.0		 2xz5D-1ig8A:
21.68
2xz5E-1ig8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 5 ASN A 267
ALA A 239
GLY A 238
TYR A 240
 None
 1.10A 3bcrA-1ig8A:
undetectable		 3bcrA-1ig8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 216
GLY A 229
ILE A 414
LYS A 452
PRO A 455
 None
 1.37A 3bjwE-1ig8A:
undetectable		 3bjwE-1ig8A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 267
ALA A 239
GLY A 238
TYR A 240
 None
 1.08A 3dd1A-1ig8A:
undetectable		 3dd1A-1ig8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 267
ALA A 239
GLY A 238
TYR A 240
 None
 1.13A 3dd1B-1ig8A:
undetectable		 3dd1B-1ig8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 267
ALA A 239
GLY A 238
TYR A 240
 None
 1.10A 3ddsA-1ig8A:
0.9		 3ddsA-1ig8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 267
ALA A 239
GLY A 238
TYR A 240
 None
 1.11A 3ddsB-1ig8A:
0.4		 3ddsB-1ig8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 267
ALA A 239
GLY A 238
TYR A 240
 None
 1.11A 3ddwA-1ig8A:
undetectable		 3ddwA-1ig8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 267
ALA A 239
GLY A 238
TYR A 240
 None
 1.12A 3ddwB-1ig8A:
undetectable		 3ddwB-1ig8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 8 LEU A  41
GLY A 399
ALA A 401
ILE A 453
ILE A 438
 None
 0.94A 3ekpA-1ig8A:
undetectable		 3ekpA-1ig8A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 201
ILE A 196
PHE A 130
TYR A 112
VAL A  94
 None
 1.39A 3elzB-1ig8A:
0.0		 3elzB-1ig8A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 4 GLN A 193
PRO A 190
VAL A 189
GLU A 168
 None
 1.14A 3huoA-1ig8A:
0.0		 3huoA-1ig8A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 199
ASP A 140
ASP A 133
 None
 0.90A 3jayA-1ig8A:
0.0		 3jayA-1ig8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 232
VAL A 420
VAL A 236
GLY A 307
 None
 0.94A 3kmoB-1ig8A:
undetectable		 3kmoB-1ig8A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 333
SER A 334
PHE A 336
ILE A 371
 None
 0.95A 3ko0B-1ig8A:
0.0		 3ko0B-1ig8A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 135
LEU A 192
PHE A 155
ILE A  85
PHE A  82
 None
 1.27A 3ko0A-1ig8A:
undetectable
3ko0B-1ig8A:
0.0
3ko0I-1ig8A:
0.0
3ko0J-1ig8A:
0.0		 3ko0A-1ig8A:
12.32
3ko0B-1ig8A:
12.32
3ko0I-1ig8A:
12.32
3ko0J-1ig8A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 333
SER A 334
PHE A 336
ILE A 371
 None
 0.97A 3ko0S-1ig8A:
0.0		 3ko0S-1ig8A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  84
ARG A  93
LYS A 111
 None
 1.12A 3kp5B-1ig8A:
0.0		 3kp5B-1ig8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 10 VAL A  95
VAL A  97
LEU A  99
GLY A 461
GLY A 463
 None
 1.20A 3ls4H-1ig8A:
undetectable		 3ls4H-1ig8A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 467
SER A 460
GLY A 214
SER A 158
 None
 0.92A 3lslA-1ig8A:
undetectable
3lslD-1ig8A:
undetectable		 3lslA-1ig8A:
18.40
3lslD-1ig8A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 8 SER A 158
ILE A 467
SER A 460
GLY A 214
 None
 0.86A 3lslA-1ig8A:
undetectable
3lslD-1ig8A:
undetectable		 3lslA-1ig8A:
18.40
3lslD-1ig8A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  41
GLY A 399
ALA A 401
ILE A 453
ILE A 438
 None
 0.89A 3nu4B-1ig8A:
undetectable		 3nu4B-1ig8A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  41
GLY A 399
ALA A 401
ILE A 453
ILE A 438
 None
 0.91A 3nujB-1ig8A:
undetectable		 3nujB-1ig8A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  41
GLY A 399
ALA A 401
ILE A 453
ILE A 438
 None
 0.95A 3nuoB-1ig8A:
undetectable		 3nuoB-1ig8A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 8 ILE A 203
ILE A 147
SER A 134
GLU A 141
VAL A  94
 None
 1.49A 3ua5A-1ig8A:
undetectable		 3ua5A-1ig8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 270
VAL A 397
CYH A 404
ILE A 414
 None
 1.24A 4bqtC-1ig8A:
0.0
4bqtD-1ig8A:
0.0		 4bqtC-1ig8A:
21.68
4bqtD-1ig8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 270
VAL A 397
CYH A 404
ILE A 414
 None
 1.29A 4bqtC-1ig8A:
0.0
4bqtD-1ig8A:
0.0		 4bqtC-1ig8A:
21.68
4bqtD-1ig8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 232
VAL A 230
LEU A 435
TYR A 270
 None
 0.78A 4f5zA-1ig8A:
undetectable		 4f5zA-1ig8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 384
ILE A 388
ARG A 391
 None
 0.63A 4mk4B-1ig8A:
undetectable		 4mk4B-1ig8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  41
GLY A 399
ALA A 401
ILE A 453
ILE A 438
 None
 0.93A 4rvjB-1ig8A:
undetectable		 4rvjB-1ig8A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  41
GLY A 399
ALA A 401
ILE A 453
ILE A 438
 None
 0.92A 4rvjD-1ig8A:
undetectable		 4rvjD-1ig8A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 161
VAL A 188
LEU A 127
LEU A  87
PHE A 159
 None
 1.13A 4zmeA-1ig8A:
0.0		 4zmeA-1ig8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 161
VAL A 188
LEU A 127
LEU A  87
PHE A 159
 None
 1.13A 4zmeB-1ig8A:
undetectable		 4zmeB-1ig8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		6 / 12 ARG A 394
LEU A  41
GLY A 399
ALA A 401
ILE A 453
ILE A 438
 None
 1.34A 5e5jB-1ig8A:
undetectable		 5e5jB-1ig8A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 311
LEU A 333
GLY A 325
PHE A 365
MET A 319
 None
 1.14A 5eskA-1ig8A:
0.0		 5eskA-1ig8A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 180
PRO A 181
ILE A 183
 None
 0.26A 5hw8F-1ig8A:
0.0		 5hw8F-1ig8A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 453
ALA A 432
GLY A 418
PHE A 232
GLY A 229
VAL A 230
 None
None
SO4  A 501 (-3.1A)
None
None
None
 1.41A 5i73A-1ig8A:
0.4		 5i73A-1ig8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 295
GLY A 297
GLN A 299
THR A 300
 None
 0.62A 5sxqA-1ig8A:
1.0		 5sxqA-1ig8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 295
GLY A 297
GLN A 299
THR A 300
 None
 0.62A 5sxqB-1ig8A:
0.0		 5sxqB-1ig8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 295
GLY A 297
GLN A 299
THR A 300
 None
 0.64A 5sxtA-1ig8A:
1.2		 5sxtA-1ig8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 295
GLY A 297
GLN A 299
THR A 300
 None
 0.62A 5sxtB-1ig8A:
1.1		 5sxtB-1ig8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 295
GLY A 297
GLN A 299
THR A 300
 None
 0.65A 5syjA-1ig8A:
1.3		 5syjA-1ig8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 295
GLY A 297
GLN A 299
THR A 300
 None
 0.76A 5syjB-1ig8A:
1.6		 5syjB-1ig8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 11 SER A 158
ILE A 467
THR A 213
ILE A 166
GLN A 163
 None
 1.24A 5y80A-1ig8A:
0.0		 5y80A-1ig8A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1ig8 HEXOKINASE PII
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 218
GLY A 214
THR A 213
THR A 222
PHE A 105
 None
 1.18A 5ybbA-1ig8A:
undetectable		 5ybbA-1ig8A:
21.39