SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1igr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1
(Homo
sapiens) 		5 / 12 LEU A 331
LEU A 320
ALA A 317
LEU A 372
LEU A 366
 None
 1.41A 2oaxE-1igrA:
undetectable		 2oaxE-1igrA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1
(Homo
sapiens) 		3 / 3 LEU A  55
LEU A  95
PHE A  70
 None
 0.71A 2pgrA-1igrA:
undetectable		 2pgrA-1igrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1
(Homo
sapiens) 		5 / 11 MET A  92
ILE A  89
LEU A  69
LEU A  95
LEU A 100
 None
 1.29A 3a50C-1igrA:
undetectable		 3a50C-1igrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1
(Homo
sapiens) 		5 / 12 MET A  92
ILE A  89
LEU A  69
LEU A  95
LEU A 100
 None
 1.28A 3a50E-1igrA:
undetectable		 3a50E-1igrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1
(Homo
sapiens) 		4 / 9 PHE A 390
PHE A 371
ILE A 351
MET A 348
 None
 1.35A 4jvlA-1igrA:
0.0		 4jvlA-1igrA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_2
(SERUM ALBUMIN)		 1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1
(Homo
sapiens) 		4 / 4 VAL A  60
GLU A  91
ASP A  97
LYS A 143
 None
 1.26A 4l9qA-1igrA:
undetectable		 4l9qA-1igrA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1
(Homo
sapiens) 		3 / 3 ASP A 405
ASN A 408
SER A 427
 None
 0.81A 4obwA-1igrA:
undetectable		 4obwA-1igrA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1
(Homo
sapiens) 		4 / 7 ARG A 180
THR A 177
ASP A  97
GLY A  67
 SO4  A 493 (-4.1A)
SO4  A 493 (-2.9A)
None
None
 0.97A 5hwaA-1igrA:
0.0		 5hwaA-1igrA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1
(Homo
sapiens) 		4 / 8 GLY A  99
LEU A 100
VAL A 125
LEU A  87
 None
 0.72A 6czmD-1igrA:
undetectable
6czmF-1igrA:
undetectable		 6czmD-1igrA:
21.19
6czmF-1igrA:
21.19