SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1igt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 1igt IGG2A INTACT
ANTIBODY - MAB231
(Mus
musculus) 		5 / 12 ILE B 351
VAL B 286
SER B 323
VAL B 321
VAL B 276
 None
 1.22A 3iw1A-1igtB:
0.0		 3iw1A-1igtB:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1igt IGG2A INTACT
ANTIBODY - MAB231
(Mus
musculus) 		3 / 3 SER B 216
ALA B 211
VAL B 210
 None
 0.62A 4o2bC-1igtB:
undetectable		 4o2bC-1igtB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1igt IGG2A INTACT
ANTIBODY - MAB231
(Mus
musculus) 		3 / 3 SER B 216
ALA B 211
VAL B 210
 None
 0.58A 4x1iA-1igtB:
undetectable		 4x1iA-1igtB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1igt IGG2A INTACT
ANTIBODY - MAB231
(Mus
musculus) 		3 / 3 SER B 216
ALA B 211
VAL B 210
 None
 0.54A 5eypA-1igtB:
undetectable		 5eypA-1igtB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 1igt IGG2A INTACT
ANTIBODY - MAB231
(Mus
musculus) 		3 / 3 SER B 216
ALA B 211
VAL B 210
 None
 0.48A 5xiwC-1igtB:
undetectable		 5xiwC-1igtB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 1igt IGG2A INTACT
ANTIBODY - MAB231
(Mus
musculus) 		5 / 12 VAL B 459
VAL B 272
GLN B 328
PHE B 338
ILE B 355
 None
 1.47A 6becA-1igtB:
2.8
6becB-1igtB:
2.7
6becC-1igtB:
2.0		 6becA-1igtB:
23.24
6becB-1igtB:
23.24
6becC-1igtB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 1igt IGG2A INTACT
ANTIBODY - MAB231
(Mus
musculus) 		3 / 3 TRP B 290
ILE B 255
GLU B 337
 None
 0.86A 6hcxA-1igtB:
undetectable		 6hcxA-1igtB:
12.60