SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1igw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		4 / 8 ALA A 131
LEU A  78
ALA A  81
LYS A  82
 None
 0.77A 1e7cA-1igwA:
undetectable		 1e7cA-1igwA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		4 / 8 TYR A 112
GLY A  92
VAL A 183
PHE A 162
 None
PYR  A1444 (-3.7A)
None
None
 1.20A 1gsfA-1igwA:
0.0		 1gsfA-1igwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		4 / 8 TYR A 112
LEU A  90
VAL A 183
PHE A 162
 None
 1.09A 1gsfA-1igwA:
0.0		 1gsfA-1igwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		4 / 8 TYR A 112
GLY A  92
VAL A 183
PHE A 162
 None
PYR  A1444 (-3.7A)
None
None
 1.21A 1gsfB-1igwA:
0.0		 1gsfB-1igwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		4 / 8 TYR A 112
LEU A  90
VAL A 183
PHE A 162
 None
 1.09A 1gsfB-1igwA:
0.0		 1gsfB-1igwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		4 / 8 TYR A 112
GLY A  92
VAL A 183
PHE A 162
 None
PYR  A1444 (-3.7A)
None
None
 1.20A 1gsfD-1igwA:
0.0		 1gsfD-1igwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		4 / 8 TYR A 112
LEU A  90
VAL A 183
PHE A 162
 None
 1.09A 1gsfD-1igwA:
0.0		 1gsfD-1igwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		5 / 12 VAL A 120
ALA A 182
MET A 175
GLY A  92
TYR A 112
 None
None
None
PYR  A1444 (-3.7A)
None
 1.15A 1kiaB-1igwA:
undetectable		 1kiaB-1igwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		4 / 5 ARG A 217
LEU A 313
ASP A 284
LEU A 228
 None
 1.12A 1n13B-1igwA:
0.0
1n13C-1igwA:
0.0		 1n13B-1igwA:
14.02
1n13C-1igwA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		5 / 12 GLU A  42
ASP A 221
ALA A 220
ILE A 176
ARG A  36
 None
 1.20A 1s14B-1igwA:
0.3		 1s14B-1igwA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		5 / 11 TYR A 282
SER A  28
ILE A 210
VAL A 214
ALA A 215
 None
 1.00A 1uduA-1igwA:
undetectable		 1uduA-1igwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		5 / 10 TYR A 279
ALA A 280
ALA A 231
ALA A 283
TYR A 282
 None
 1.32A 2r2vC-1igwA:
0.0
2r2vF-1igwA:
0.0
2r2vG-1igwA:
0.0		 2r2vC-1igwA:
6.95
2r2vF-1igwA:
6.95
2r2vG-1igwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		5 / 12 LEU A 229
ALA A 209
ALA A 283
VAL A 286
PHE A 301
 None
 1.21A 3b0wB-1igwA:
0.0		 3b0wB-1igwA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		4 / 4 THR A 395
VAL A 403
GLY A  75
THR A  73
 None
 1.09A 3cflA-1igwA:
0.0		 3cflA-1igwA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		5 / 12 ILE A 269
GLN A 303
ALA A 298
LEU A 297
GLY A 344
 None
 1.07A 3ozwB-1igwA:
undetectable		 3ozwB-1igwA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		3 / 3 LYS A  82
LEU A  78
ALA A  81
 None
 0.69A 4ikiA-1igwA:
0.0		 4ikiA-1igwA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		4 / 5 LEU A 229
MET A 175
LEU A 171
HIS A 184
 None
None
None
PYR  A1444 (-4.5A)
 1.37A 4xi3B-1igwA:
0.0		 4xi3B-1igwA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		5 / 12 LEU A 171
GLY A 163
ASP A 187
THR A 233
VAL A 183
 None
 1.35A 5d0yA-1igwA:
0.0		 5d0yA-1igwA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1igw ISOCITRATE LYASE
(Escherichia
coli) 		4 / 6 PHE A 128
ARG A 130
ALA A  81
GLN A 133
 None
 0.86A 6b89B-1igwA:
0.6		 6b89B-1igwA:
11.92