SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1igy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1igy IGG1 INTACT ANTIBODY
MAB61.1.3
(Mus
musculus) 		5 / 12 THR B 422
PRO B 424
ILE B 400
VAL B 402
VAL B 437
 None
 1.22A 1z9hD-1igyB:
undetectable		 1z9hD-1igyB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 1igy IGG1 INTACT ANTIBODY
MAB61.1.3
(Mus
musculus) 		4 / 6 ASP B 262
VAL B 268
PRO B 260
THR B 401
 GAL  B 481 ( 4.6A)
None
None
None
 1.44A 2q6oB-1igyB:
undetectable		 2q6oB-1igyB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 1igy IGG1 INTACT ANTIBODY
MAB61.1.3
(Mus
musculus) 		4 / 8 THR B  57
ASN B  58
TYR B  59
TYR B  50
 None
 1.02A 3dmtC-1igyB:
undetectable		 3dmtC-1igyB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 1igy IGG1 INTACT ANTIBODY
MAB61.1.3
(Mus
musculus) 		3 / 3 GLU B  46
PHE B  63
GLN B  61
 None
 0.98A 3r55A-1igyB:
0.0		 3r55A-1igyB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1igy IGG1 INTACT ANTIBODY
MAB61.1.3
(Mus
musculus) 		4 / 6 ILE B  80
ARG B  62
THR B  83
LEU B  82
 None
 1.02A 3wg7N-1igyB:
undetectable
3wg7W-1igyB:
0.0		 3wg7N-1igyB:
20.39
3wg7W-1igyB:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1igy IGG1 INTACT ANTIBODY
MAB61.1.3
(Mus
musculus) 		3 / 3 TYR B  90
ARG B  40
LYS B  38
 None
 1.30A 4wq5B-1igyB:
0.0		 4wq5B-1igyB:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1igy IGG1 INTACT ANTIBODY
MAB61.1.3
(Mus
musculus) 		5 / 12 LEU B 166
VAL B 191
ILE B 223
LEU B 140
VAL B 219
 None
 0.98A 4y0qA-1igyB:
undetectable		 4y0qA-1igyB:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 1igy IGG1 INTACT ANTIBODY
MAB61.1.3
(Mus
musculus) 		4 / 8 ASP B  85
ASP B  86
ILE B  80
TYR B  59
 None
 1.05A 5cfsA-1igyB:
0.0		 5cfsA-1igyB:
15.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 1igy IGG1 INTACT ANTIBODY
MAB61.1.3
(Mus
musculus) 		5 / 5 SER B 112
ALA B 114
PHE B 148
LEU B 178
ASP B 183
 None
 1.03A 5mthA-1igyB:
18.8		 5mthA-1igyB:
80.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 1igy IGG1 INTACT ANTIBODY
MAB61.1.3
(Mus
musculus) 		3 / 3 TRP B 290
ILE B 255
GLU B 337
 None
NAG  B 483 ( 3.8A)
None
 0.78A 6hcxA-1igyB:
undetectable		 6hcxA-1igyB:
10.87