SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ih5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		4 / 6 ASN A 192
GLY A 173
ILE A 172
ILE A 191
 None
 0.93A 1n49D-1ih5A:
undetectable		 1n49D-1ih5A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		5 / 12 ALA A  20
LEU A  63
ILE A  70
GLY A  72
LEU A  75
 None
 0.94A 1qknA-1ih5A:
undetectable		 1qknA-1ih5A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		4 / 6 PHE A 197
THR A 109
VAL A 107
ALA A 194
 None
 1.05A 2e1qA-1ih5A:
0.0		 2e1qA-1ih5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		4 / 6 PHE A 197
THR A 109
VAL A 107
ALA A 194
 None
 1.04A 2e1qC-1ih5A:
0.0		 2e1qC-1ih5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		4 / 6 ALA A 105
ASN A  76
PRO A 193
ALA A 194
 None
 1.16A 2zgwB-1ih5A:
0.1		 2zgwB-1ih5A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		4 / 8 LEU A  54
GLY A  30
ALA A  32
ILE A 184
 None
 0.70A 3jusA-1ih5A:
1.4		 3jusA-1ih5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		4 / 8 LEU A  54
GLY A  30
ALA A  32
ILE A 184
 None
 0.70A 3jusA-1ih5A:
1.4		 3jusA-1ih5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		4 / 8 LEU A  54
GLY A  30
ALA A  32
ILE A 184
 None
 0.66A 3jusB-1ih5A:
undetectable		 3jusB-1ih5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		5 / 9 THR A 109
ALA A 110
LEU A 112
ASN A 127
ARG A 126
 None
 1.42A 3kp6B-1ih5A:
0.0		 3kp6B-1ih5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		5 / 12 LEU A  19
ALA A  20
LEU A  63
ILE A  70
GLY A  72
 None
 0.98A 3q95B-1ih5A:
undetectable		 3q95B-1ih5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		4 / 7 GLY A 145
THR A 146
SER A  53
PHE A  56
 None
 0.87A 4ac9C-1ih5A:
undetectable		 4ac9C-1ih5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		5 / 12 ALA A  20
LEU A  63
ILE A  70
GLY A  72
LEU A  75
 None
 0.93A 4xi3B-1ih5A:
undetectable		 4xi3B-1ih5A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		5 / 12 LEU A  19
ALA A  20
LEU A  63
GLY A  72
LEU A  75
 None
 1.01A 4xi3C-1ih5A:
undetectable		 4xi3C-1ih5A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		5 / 11 ASP A 158
THR A 157
VAL A 153
VAL A  79
LEU A 151
 None
 1.45A 5jkwA-1ih5A:
0.0		 5jkwA-1ih5A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		5 / 7 GLY A 145
LEU A 147
LEU A  81
ILE A 143
GLY A 140
 None
 1.25A 5vkqA-1ih5A:
undetectable
5vkqB-1ih5A:
undetectable		 5vkqA-1ih5A:
10.44
5vkqB-1ih5A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		5 / 8 GLY A 145
LEU A 147
LEU A  81
ILE A 143
GLY A 140
 None
 1.23A 5vkqB-1ih5A:
undetectable
5vkqC-1ih5A:
undetectable		 5vkqB-1ih5A:
10.44
5vkqC-1ih5A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 1ih5 AQUAPORIN-1
(Homo
sapiens) 		4 / 7 ASN A  76
GLY A 219
ALA A 221
LEU A  81
 None
 0.77A 6dwnB-1ih5A:
1.2		 6dwnB-1ih5A:
16.03