SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ihb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 1ihb CYCLIN-DEPENDENT
KINASE 6 INHIBITOR
(Homo
sapiens) 		5 / 12 ILE A  98
ALA A  72
LEU A 109
PRO A 106
LEU A 122
 None
 1.15A 1og5B-1ihbA:
0.0		 1og5B-1ihbA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ihb CYCLIN-DEPENDENT
KINASE 6 INHIBITOR
(Homo
sapiens) 		4 / 5 ARG A 145
VAL A 152
LEU A 155
SER A 154
 None
 1.17A 4e1gA-1ihbA:
undetectable		 4e1gA-1ihbA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1ihb CYCLIN-DEPENDENT
KINASE 6 INHIBITOR
(Homo
sapiens) 		4 / 6 ARG A  79
ASP A  67
GLY A  70
ASP A 100
 None
 1.12A 5hp1A-1ihbA:
undetectable		 5hp1A-1ihbA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1ihb CYCLIN-DEPENDENT
KINASE 6 INHIBITOR
(Homo
sapiens) 		5 / 12 LEU A  21
LEU A  18
ALA A  61
LEU A   9
GLN A  26
 None
 1.10A 6ew0B-1ihbA:
undetectable		 6ew0B-1ihbA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 1ihb CYCLIN-DEPENDENT
KINASE 6 INHIBITOR
(Homo
sapiens) 		5 / 12 LEU A  21
LEU A  18
ALA A  61
LEU A   9
GLN A  26
 None
 1.10A 6ew0D-1ihbA:
undetectable		 6ew0D-1ihbA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 1ihb CYCLIN-DEPENDENT
KINASE 6 INHIBITOR
(Homo
sapiens) 		5 / 12 LEU A  21
LEU A  18
ALA A  61
LEU A   9
GLN A  26
 None
 1.10A 6ew0H-1ihbA:
undetectable		 6ew0H-1ihbA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 1ihb CYCLIN-DEPENDENT
KINASE 6 INHIBITOR
(Homo
sapiens) 		5 / 12 LEU A  21
LEU A  18
ALA A  61
LEU A   9
GLN A  26
 None
 1.09A 6ew0I-1ihbA:
undetectable		 6ew0I-1ihbA:
20.50