SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ihc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 1ihc GEPHYRIN
(Rattus
norvegicus) 		5 / 12 LEU A  70
LEU A  79
ILE A 104
ILE A 135
GLY A 137
 None
 0.98A 1qknA-1ihcA:
undetectable		 1qknA-1ihcA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1ihc GEPHYRIN
(Rattus
norvegicus) 		4 / 8 VAL A  59
THR A  69
THR A 100
ALA A  99
 None
 0.69A 2a1hA-1ihcA:
undetectable
2a1hB-1ihcA:
undetectable		 2a1hA-1ihcA:
19.57
2a1hB-1ihcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ihc GEPHYRIN
(Rattus
norvegicus) 		5 / 12 LEU A  48
GLY A  18
ILE A 166
LEU A 162
LEU A 159
 None
 0.93A 3adxB-1ihcA:
undetectable		 3adxB-1ihcA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1ihc GEPHYRIN
(Rattus
norvegicus) 		5 / 8 GLY A 110
GLU A 107
ILE A 158
ALA A 161
PHE A 157
 None
 1.31A 3aodA-1ihcA:
undetectable		 3aodA-1ihcA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 1ihc GEPHYRIN
(Rattus
norvegicus) 		5 / 12 GLY A  86
GLY A  87
VAL A  22
LEU A  39
ILE A  66
 None
 1.16A 3h52B-1ihcA:
undetectable		 3h52B-1ihcA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1ihc GEPHYRIN
(Rattus
norvegicus) 		3 / 3 LEU A  70
ASP A  75
ILE A 142
 None
 0.61A 4xi3D-1ihcA:
undetectable		 4xi3D-1ihcA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1ihc GEPHYRIN
(Rattus
norvegicus) 		3 / 3 LYS A  57
LEU A  79
ASP A  72
 None
 0.94A 5zv2A-1ihcA:
undetectable		 5zv2A-1ihcA:
17.58