SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		5 / 8 ALA A 272
LEU A 204
LEU A 269
LEU A 193
ALA A 201
 None
 1.39A 1e7cA-1ihoA:
undetectable		 1e7cA-1ihoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		5 / 12 HIS A  34
GLY A  36
HIS A  37
GLY A 149
ASP A 152
 None
 1.01A 1qu2A-1ihoA:
2.0		 1qu2A-1ihoA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		4 / 8 LEU A 215
LEU A 222
ASP A 247
ARG A 220
 None
 1.03A 2j2pA-1ihoA:
0.0
2j2pB-1ihoA:
0.0		 2j2pA-1ihoA:
20.26
2j2pB-1ihoA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		5 / 12 HIS A  34
GLY A  36
HIS A  37
GLY A 149
ASP A 152
 None
 1.04A 2x1lB-1ihoA:
7.1		 2x1lB-1ihoA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		5 / 11 HIS A  34
GLY A  36
HIS A  37
GLY A 149
ASP A 152
 None
 1.04A 2x1lC-1ihoA:
5.8		 2x1lC-1ihoA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		5 / 10 ILE A 177
PHE A 238
ALA A 272
LEU A 274
ALA A 267
 None
 1.21A 3lw5B-1ihoA:
undetectable		 3lw5B-1ihoA:
17.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		6 / 8 GLN A  61
ARG A 123
HIS A 126
VAL A 130
ASP A 152
GLN A 155
 EDO  A 702 (-2.9A)
None
None
EDO  A 702 ( 4.7A)
None
EDO  A 702 (-3.0A)
 0.65A 3uy4A-1ihoA:
31.3		 3uy4A-1ihoA:
42.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		4 / 8 ARG A  73
ASP A  78
LEU A  75
ILE A   3
 None
 0.86A 4k0bA-1ihoA:
undetectable		 4k0bA-1ihoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		4 / 8 ARG A  73
ASP A  78
LEU A  75
ILE A   3
 None
 1.02A 4l7iA-1ihoA:
0.0		 4l7iA-1ihoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		4 / 4 ILE A  14
VAL A  51
VAL A  24
ARG A  18
 None
 1.20A 4m6tA-1ihoA:
undetectable		 4m6tA-1ihoA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		4 / 7 ARG A 160
VAL A 173
GLU A 171
ARG A  47
 None
 1.36A 4mv7A-1ihoA:
4.3		 4mv7A-1ihoA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		5 / 10 ALA A 229
ILE A 243
GLY A 203
LEU A 204
ALA A 267
 None
 1.41A 5ajqB-1ihoA:
undetectable		 5ajqB-1ihoA:
24.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		5 / 12 HIS A  34
GLY A  36
GLY A 149
LYS A 151
ASP A 152
 None
 1.00A 5hg0A-1ihoA:
26.4		 5hg0A-1ihoA:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		7 / 12 HIS A  34
GLY A  36
LEU A  40
GLN A  61
TYR A  71
GLY A 149
ASP A 152
 None
None
None
EDO  A 702 (-2.9A)
None
None
None
 0.63A 5hg0A-1ihoA:
26.4		 5hg0A-1ihoA:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		7 / 12 HIS A  34
GLY A  36
HIS A  37
LEU A  40
TYR A  71
GLY A 149
ASP A 152
 None
 0.62A 5hg0B-1ihoA:
26.4		 5hg0B-1ihoA:
36.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 1iho PANTOATE--BETA-ALANI
NE LIGASE
(Escherichia
coli) 		4 / 6 LEU A  40
CYH A 147
GLY A 174
ARG A  47
 None
 1.26A 6gtqB-1ihoA:
0.0
6gtqD-1ihoA:
undetectable		 6gtqB-1ihoA:
19.65
6gtqD-1ihoA:
11.39