SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ii2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		3 / 3 VAL A 330
VAL A 216
TRP A 411
 None
 0.91A 1bdwA-1ii2A:
undetectable
1bdwB-1ii2A:
undetectable		 1bdwA-1ii2A:
3.38
1bdwB-1ii2A:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		3 / 3 ARG A 236
GLY A 214
ASP A 215
 None
 0.59A 1kf6A-1ii2A:
undetectable
1kf6B-1ii2A:
0.0		 1kf6A-1ii2A:
22.74
1kf6B-1ii2A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		4 / 4 HIS A 205
ALA A 206
PHE A 219
GLY A 221
 None
 1.31A 1mj2B-1ii2A:
undetectable		 1mj2B-1ii2A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		4 / 4 HIS A 205
ALA A 206
PHE A 219
GLY A 221
 None
 1.39A 1mj2D-1ii2A:
undetectable		 1mj2D-1ii2A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		4 / 4 HIS A 205
ALA A 206
PHE A 219
GLY A 221
 None
 1.35A 1mjoB-1ii2A:
undetectable		 1mjoB-1ii2A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		4 / 4 HIS A 205
ALA A 206
PHE A 219
GLY A 221
 None
 1.31A 1mjoA-1ii2A:
undetectable		 1mjoA-1ii2A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		4 / 4 HIS A 205
ALA A 206
PHE A 219
GLY A 221
 None
 1.34A 1mjoD-1ii2A:
undetectable		 1mjoD-1ii2A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		3 / 3 ALA A 337
VAL A 340
TRP A 479
 None
 0.85A 1nt6A-1ii2A:
undetectable		 1nt6A-1ii2A:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		3 / 3 ALA A 337
VAL A 340
TRP A 479
 None
 0.85A 1nt6B-1ii2A:
undetectable		 1nt6B-1ii2A:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 12 THR A 334
ASN A 414
GLY A 339
ARG A 421
ALA A 337
 None
 1.26A 2axnA-1ii2A:
undetectable		 2axnA-1ii2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 12 THR A 415
THR A 361
GLY A 224
GLY A 226
GLY A 221
 None
None
SO4  A   1 (-3.2A)
SO4  A   1 (-3.3A)
None
 0.99A 2b25A-1ii2A:
undetectable		 2b25A-1ii2A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		4 / 8 ARG A  43
THR A 178
GLY A 182
ILE A 175
 None
 0.73A 2f9wA-1ii2A:
undetectable
2f9wB-1ii2A:
undetectable		 2f9wA-1ii2A:
19.62
2f9wB-1ii2A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		6 / 8 ARG A  43
LYS A 185
LYS A 186
HIS A 205
ASP A 242
ARG A 307
 None
 0.85A 2rk8A-1ii2A:
31.3		 2rk8A-1ii2A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		6 / 7 ARG A  43
LYS A 185
LYS A 186
HIS A 205
ASP A 242
ARG A 307
 None
 0.70A 2rk8B-1ii2A:
30.1		 2rk8B-1ii2A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APT_B_ACTB311_0
(METHYLENETETRAHYDROF
OLATE REDUCTASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 9 LEU A 238
ASP A 241
ALA A 232
ILE A 315
TYR A 310
 None
 1.40A 3aptB-1ii2A:
undetectable		 3aptB-1ii2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		4 / 6 GLY A  42
GLU A 284
GLY A 182
ASN A 305
 None
 1.06A 3e9rA-1ii2A:
undetectable		 3e9rA-1ii2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		4 / 6 GLY A  42
GLU A 284
GLY A 182
ASN A 305
 None
 1.09A 3e9rC-1ii2A:
undetectable		 3e9rC-1ii2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 224
GLY A 226
LEU A 222
ASN A 363
VAL A 364
 SO4  A   1 (-3.2A)
SO4  A   1 (-3.3A)
None
None
None
 1.01A 3eluA-1ii2A:
undetectable		 3eluA-1ii2A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		3 / 3 TYR A 259
TYR A 116
GLY A 182
 None
 0.57A 3eteB-1ii2A:
undetectable
3eteD-1ii2A:
undetectable
3eteF-1ii2A:
undetectable		 3eteB-1ii2A:
23.87
3eteD-1ii2A:
23.87
3eteF-1ii2A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 12 THR A 112
LEU A  33
GLN A  16
TYR A 116
LEU A 119
 None
 1.41A 3fsuA-1ii2A:
undetectable		 3fsuA-1ii2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		3 / 3 THR A 162
GLU A 183
HIS A 117
 None
 0.78A 3g1uB-1ii2A:
undetectable		 3g1uB-1ii2A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  30
THR A  41
ALA A 262
ILE A 295
LEU A 265
 None
 1.39A 3lcvB-1ii2A:
undetectable		 3lcvB-1ii2A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 12 LYS A 186
GLY A 221
GLY A 384
LEU A 230
ASP A 242
 None
 1.14A 4blvB-1ii2A:
undetectable		 4blvB-1ii2A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		3 / 3 ASP A 242
LEU A 312
VAL A 277
 None
 0.70A 4jecB-1ii2A:
undetectable		 4jecB-1ii2A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		3 / 3 LEU A 106
ASP A 140
TYR A 141
 None
 0.60A 4qc6B-1ii2A:
0.0		 4qc6B-1ii2A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		3 / 3 PHE A 496
THR A 225
LEU A 412
 None
 0.79A 4qztA-1ii2A:
0.0		 4qztA-1ii2A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		4 / 5 GLY A  42
TYR A  38
SER A  37
GLU A 183
 None
 1.21A 4xueA-1ii2A:
undetectable		 4xueA-1ii2A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 10 GLY A 366
VAL A 367
GLU A 368
THR A 372
VAL A 364
 None
 1.32A 4yb6A-1ii2A:
0.0
4yb6E-1ii2A:
0.0		 4yb6A-1ii2A:
22.41
4yb6E-1ii2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 10 GLY A 366
VAL A 367
GLU A 368
THR A 372
VAL A 364
 None
 1.29A 4yb6C-1ii2A:
undetectable
4yb6F-1ii2A:
1.2		 4yb6C-1ii2A:
22.41
4yb6F-1ii2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 10 GLY A 366
VAL A 367
GLU A 368
THR A 372
VAL A 364
 None
 1.32A 4yb6A-1ii2A:
0.0
4yb6D-1ii2A:
undetectable		 4yb6A-1ii2A:
22.41
4yb6D-1ii2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 10 GLY A 366
VAL A 367
GLU A 368
THR A 372
VAL A 364
 None
 1.28A 4yb6D-1ii2A:
undetectable
4yb6E-1ii2A:
0.0		 4yb6D-1ii2A:
22.41
4yb6E-1ii2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		4 / 6 TRP A  62
ILE A  50
ILE A 155
VAL A  77
 None
 0.93A 4zj8A-1ii2A:
undetectable		 4zj8A-1ii2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 7 ILE A 126
CYH A  96
LEU A 125
GLY A 257
GLY A 256
 None
 1.03A 5a06A-1ii2A:
undetectable		 5a06A-1ii2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		4 / 7 ILE A 126
CYH A  96
GLY A 257
GLY A 256
 None
 0.83A 5a06B-1ii2A:
undetectable		 5a06B-1ii2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 7 ILE A 126
CYH A  96
LEU A 125
GLY A 257
GLY A 256
 None
 1.01A 5a06C-1ii2A:
undetectable		 5a06C-1ii2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 7 ILE A 126
CYH A  96
LEU A 125
GLY A 257
GLY A 256
 None
 1.03A 5a06E-1ii2A:
undetectable		 5a06E-1ii2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 7 ILE A 126
CYH A  96
LEU A 125
GLY A 257
GLY A 256
 None
 1.02A 5a06F-1ii2A:
undetectable		 5a06F-1ii2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		3 / 3 PRO A  12
ARG A 122
GLU A  13
 None
 0.84A 5j6hA-1ii2A:
0.0		 5j6hA-1ii2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		4 / 8 LEU A 472
ALA A 426
VAL A 468
MET A 429
 None
 0.89A 5nu7A-1ii2A:
0.0		 5nu7A-1ii2A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		3 / 3 GLY A 458
THR A 415
PRO A 342
 None
 0.60A 5v5zA-1ii2A:
0.0		 5v5zA-1ii2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		5 / 12 GLU A 284
VAL A 282
GLU A 255
ARG A 307
HIS A 205
 None
 1.50A 5xipB-1ii2A:
undetectable		 5xipB-1ii2A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Trypanosoma
cruzi) 		4 / 5 TYR A 395
GLY A 396
HIS A 391
ASP A  61
 None
 1.20A 6gh9A-1ii2A:
undetectable		 6gh9A-1ii2A:
9.54