SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ii8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1ii8 RAD50 ABC-ATPASE
(Pyrococcus
furiosus) 		4 / 8 LEU B 745
ALA B 752
GLY B 801
VAL B 769
 None
 0.78A 1d4sB-1ii8B:
undetectable		 1d4sB-1ii8B:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_1
(ALCOHOL
DEHYDROGENASE)		 1ii8 RAD50 ABC-ATPASE
RAD50 ABC-ATPASE
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 4 GLU B 815
MET A   1
LEU B 818
SER B 817
 None
 1.29A 1ee2B-1ii8B:
0.7		 1ee2B-1ii8B:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1ii8 RAD50 ABC-ATPASE
RAD50 ABC-ATPASE
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 GLN A 142
LEU A 163
VAL B 769
ALA A 145
VAL B 776
 None
 1.40A 2g70B-1ii8A:
undetectable		 2g70B-1ii8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1ii8 RAD50 ABC-ATPASE
RAD50 ABC-ATPASE
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 GLN A 142
LEU A 163
ILE B 748
VAL B 769
VAL B 776
 None
 1.31A 2g72B-1ii8A:
undetectable		 2g72B-1ii8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1ii8 RAD50 ABC-ATPASE
RAD50 ABC-ATPASE
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 10 GLU B 720
ILE A 184
LYS A 177
GLU B 727
ILE A 180
 None
 1.09A 2j9dD-1ii8B:
0.0
2j9dE-1ii8B:
0.0
2j9dF-1ii8B:
undetectable		 2j9dD-1ii8B:
25.15
2j9dE-1ii8B:
24.72
2j9dF-1ii8B:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1ii8 RAD50 ABC-ATPASE
RAD50 ABC-ATPASE
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 11 ALA B 752
MET B 808
GLY B 801
ILE A 146
VAL B 776
 None
 1.17A 2uxpB-1ii8B:
undetectable		 2uxpB-1ii8B:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1ii8 RAD50 ABC-ATPASE
(Pyrococcus
furiosus) 		4 / 8 LEU B 859
ILE B 837
LEU B 836
LEU B 852
 None
 0.80A 2xfhA-1ii8B:
undetectable		 2xfhA-1ii8B:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1ii8 RAD50 ABC-ATPASE
(Pyrococcus
furiosus) 		3 / 3 ARG A   5
ASP A  16
ASP A  72
 None
 0.81A 3jb3A-1ii8A:
0.0		 3jb3A-1ii8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1ii8 RAD50 ABC-ATPASE
(Pyrococcus
furiosus) 		5 / 10 ALA B 771
LEU A 163
VAL A 157
LEU B 812
ILE B 748
 None
 1.03A 3jw3A-1ii8B:
undetectable		 3jw3A-1ii8B:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 1ii8 RAD50 ABC-ATPASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 143
ALA B 803
LEU B 802
LEU B 821
GLY B 749
 None
 1.08A 3ozwB-1ii8A:
undetectable		 3ozwB-1ii8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1ii8 RAD50 ABC-ATPASE
RAD50 ABC-ATPASE
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 ILE A 138
VAL A 160
ALA B 752
LEU B 778
VAL B 767
 None
 1.05A 3w67C-1ii8A:
undetectable		 3w67C-1ii8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1ii8 RAD50 ABC-ATPASE
RAD50 ABC-ATPASE
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 VAL A 160
ALA B 752
ILE A 146
LEU B 778
VAL B 767
 None
 1.09A 3w67C-1ii8A:
undetectable		 3w67C-1ii8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1ii8 RAD50 ABC-ATPASE
(Pyrococcus
furiosus) 		4 / 7 GLU B 786
GLU B 766
PHE B 779
VAL A 157
 None
 1.09A 4a97A-1ii8B:
undetectable		 4a97A-1ii8B:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ii8 RAD50 ABC-ATPASE
(Pyrococcus
furiosus) 		3 / 3 LEU A 176
ILE A 180
ARG A 183
 None
 0.67A 4mk4B-1ii8A:
undetectable		 4mk4B-1ii8A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1ii8 RAD50 ABC-ATPASE
(Pyrococcus
furiosus) 		5 / 8 ILE B 798
ILE B 851
ILE A  43
ILE A  28
ASP B 822
 None
 1.08A 5hi2A-1ii8B:
undetectable		 5hi2A-1ii8B:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ii8 RAD50 ABC-ATPASE
(Pyrococcus
furiosus) 		5 / 9 LEU B 859
ILE A  25
ILE B 798
GLU B 831
GLU B 823
 None
 1.25A 5igzA-1ii8B:
0.3		 5igzA-1ii8B:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1ii8 RAD50 ABC-ATPASE
RAD50 ABC-ATPASE
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		3 / 3 VAL A  19
GLU A  20
ILE B 867
 None
 0.64A 6f7lB-1ii8A:
undetectable		 6f7lB-1ii8A:
20.42