SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iid'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 329
LEU A 380
ALA A 384
ALA A 388
LEU A 306
 None
 1.27A 1cbrA-1iidA:
undetectable		 1cbrA-1iidA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 329
LEU A 380
ALA A 384
ALA A 388
LEU A 306
 None
 1.27A 1cbrB-1iidA:
undetectable		 1cbrB-1iidA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 327
ILE A 381
LEU A 411
CYH A 385
LEU A 261
 None
 1.26A 2jn3A-1iidA:
0.0		 2jn3A-1iidA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 287
PHE A 289
PHE A 276
GLY A 451
 None
 1.41A 2qmzA-1iidA:
undetectable
2qmzB-1iidA:
undetectable		 2qmzA-1iidA:
17.42
2qmzB-1iidA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 8 ALA A 429
GLU A  56
LEU A 424
LEU A 203
VAL A 452
 None
 1.46A 2uxpA-1iidA:
undetectable		 2uxpA-1iidA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 276
SER A 313
PHE A 283
ILE A 311
 None
 1.26A 2v0mD-1iidA:
0.0		 2v0mD-1iidA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 221
ASN A 397
ILE A 347
PHE A 234
 None
 1.33A 3ccfB-1iidA:
undetectable		 3ccfB-1iidA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 342
ILE A 347
GLY A 346
ASN A 392
PHE A 334
 None
 1.12A 4rvgA-1iidA:
undetectable		 4rvgA-1iidA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 9 THR A 183
VAL A 173
VAL A 137
PHE A 148
LEU A 171
 NHM  A 500 (-3.7A)
NHM  A 500 (-4.3A)
None
None
NHM  A 500 (-4.1A)
 1.50A 4wnvA-1iidA:
0.0		 4wnvA-1iidA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 328
ASP A 403
ARG A 282
GLY A 451
 None
 1.03A 5cdqA-1iidA:
0.0
5cdqC-1iidA:
undetectable
5cdqD-1iidA:
undetectable		 5cdqA-1iidA:
21.37
5cdqC-1iidA:
21.37
5cdqD-1iidA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 451
ASN A 297
PHE A 294
THR A 290
VAL A 272
 None
 1.30A 5d0yA-1iidA:
0.0		 5d0yA-1iidA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 404
LEU A 373
PHE A 327
 None
 0.82A 5dsgA-1iidA:
undetectable		 5dsgA-1iidA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 447
GLY A 435
THR A 405
ASN A 449
 None
 0.98A 5hwaA-1iidA:
0.0		 5hwaA-1iidA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 329
SER A 313
ASN A 404
ASP A 403
 None
 1.34A 5kpcA-1iidA:
0.1		 5kpcA-1iidA:
20.96