SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iir'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		3 / 3 ALA A 197
VAL A 213
TRP A 195
 None
 0.93A 1bdwA-1iirA:
undetectable
1bdwB-1iirA:
undetectable		 1bdwA-1iirA:
3.93
1bdwB-1iirA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 12 TYR A 120
GLY A 189
PRO A 131
VAL A 130
LEU A 210
 None
 1.08A 1gseB-1iirA:
1.7		 1gseB-1iirA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GYX_A_BEZA1077_0
(HYPOTHETICAL PROTEIN
YDCE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		4 / 7 PHE A 124
TYR A 135
PRO A 127
SER A 128
 None
 1.47A 1gyxA-1iirA:
0.0
1gyxB-1iirA:
0.5		 1gyxA-1iirA:
13.30
1gyxB-1iirA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 12 PHE A 121
LEU A  20
VAL A  24
VAL A  98
THR A 100
 None
 0.88A 1q23B-1iirA:
0.0		 1q23B-1iirA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 11 PHE A 121
LEU A  20
VAL A  24
VAL A  98
THR A 100
 None
 0.91A 1q23F-1iirA:
0.4		 1q23F-1iirA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		3 / 3 ARG A 157
ILE A 151
TRP A 155
 None
 1.15A 1qomA-1iirA:
0.0		 1qomA-1iirA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		3 / 3 ARG A   2
ARG A  32
ILE A 118
 None
 0.72A 1uobA-1iirA:
0.0		 1uobA-1iirA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 12 GLY A 249
HIS A 295
TYR A 242
LEU A 243
LEU A 327
 None
 1.47A 1zgyA-1iirA:
undetectable		 1zgyA-1iirA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 11 GLY A 351
SER A 358
ILE A 325
ALA A 366
THR A 371
 None
 1.07A 2nnhA-1iirA:
0.0		 2nnhA-1iirA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 12 ILE A 382
ALA A 379
GLY A 321
VAL A 340
ARG A 339
 None
 0.83A 2qe6A-1iirA:
3.6		 2qe6A-1iirA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		4 / 7 ALA A  79
THR A  82
ALA A  81
PRO A  55
 None
 0.97A 2ql8A-1iirA:
undetectable
2ql8B-1iirA:
undetectable		 2ql8A-1iirA:
17.66
2ql8B-1iirA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		4 / 7 PHE A 233
GLY A 237
ASP A 286
ARG A 263
 None
 0.99A 3aruA-1iirA:
undetectable		 3aruA-1iirA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		3 / 3 ARG A 157
ILE A 151
TRP A 155
 None
 1.07A 3e7iB-1iirA:
0.1		 3e7iB-1iirA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		4 / 8 SER A 272
PHE A 245
VAL A 257
PRO A 251
 None
 1.12A 3jq7C-1iirA:
7.9		 3jq7C-1iirA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		4 / 6 PRO A  16
GLY A 101
ALA A 197
GLN A  83
 None
 1.09A 4g0uA-1iirA:
2.3		 4g0uA-1iirA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 12 ALA A 387
ALA A 390
ALA A 391
VAL A   3
LEU A   5
 None
 1.11A 4j6dA-1iirA:
0.0		 4j6dA-1iirA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 12 ALA A 387
ALA A 390
ALA A 391
VAL A   3
LEU A   5
 None
 1.10A 4j6dB-1iirA:
undetectable		 4j6dB-1iirA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 12 LEU A 359
GLY A 346
ALA A 362
LEU A 363
GLY A 338
 None
 0.93A 4n09C-1iirA:
6.7		 4n09C-1iirA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 12 GLU A  70
THR A  77
HIS A 173
SER A 172
GLY A 168
 None
 0.95A 4q15A-1iirA:
4.5		 4q15A-1iirA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		4 / 5 LEU A  17
ALA A  35
VAL A 109
ILE A  87
 None
 0.89A 4xe3A-1iirA:
0.0		 4xe3A-1iirA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		4 / 5 LEU A  17
ALA A  35
VAL A 109
ILE A  87
 None
 0.87A 4xe3B-1iirA:
0.0		 4xe3B-1iirA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 12 GLU A  70
THR A  77
HIS A 173
SER A 172
GLY A 168
 None
 1.00A 4ydqB-1iirA:
3.5		 4ydqB-1iirA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		3 / 3 ASN A 159
LEU A 210
PHE A 188
 None
 0.82A 5dsgA-1iirA:
undetectable		 5dsgA-1iirA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		4 / 6 PRO A 251
ALA A 362
LEU A 363
TYR A 242
 None
 1.09A 5igiA-1iirA:
undetectable		 5igiA-1iirA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 11 ILE A 219
GLY A 386
PRO A 200
VAL A 201
ILE A 382
 None
 1.21A 5kr2B-1iirA:
undetectable		 5kr2B-1iirA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 9 GLY A 300
VAL A 302
ASN A 294
VAL A 293
LEU A 230
 None
 1.05A 5lw1H-1iirA:
undetectable		 5lw1H-1iirA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 12 GLU A  70
THR A  77
HIS A 173
SER A 172
GLY A 167
 None
 1.13A 5xipA-1iirA:
3.5		 5xipA-1iirA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 12 GLU A  70
THR A  77
HIS A 173
SER A 172
GLY A 168
 None
 1.00A 5xipA-1iirA:
3.5		 5xipA-1iirA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 12 VAL A 196
GLY A 338
VAL A 340
THR A 313
GLY A 312
 None
None
None
SO4  A1403 (-3.8A)
SO4  A1403 (-3.3A)
 0.81A 6brdC-1iirA:
0.8		 6brdC-1iirA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 1iir GLYCOSYLTRANSFERASE
GTFB
(Amycolatopsis
orientalis) 		5 / 12 LEU A 169
GLY A 168
TYR A 166
ILE A  80
ALA A 104
 None
 1.37A 6qyaB-1iirA:
0.0		 6qyaB-1iirA:
20.19