SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ik6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 8 THR A  60
GLY A  32
GLY A  65
LEU A  62
GLY A  69
 None
 1.37A 1jhqA-1ik6A:
undetectable		 1jhqA-1ik6A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 8 THR A  60
GLY A  32
GLY A  65
LEU A  62
GLY A  69
 None
 1.32A 1jhvA-1ik6A:
undetectable		 1jhvA-1ik6A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		4 / 7 VAL A 235
VAL A 274
LEU A 277
LEU A 237
 None
 0.71A 1pthA-1ik6A:
0.0		 1pthA-1ik6A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		4 / 7 VAL A 235
VAL A 274
LEU A 277
LEU A 237
 None
 0.70A 1pthB-1ik6A:
0.0		 1pthB-1ik6A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		3 / 3 GLU A 273
GLU A 138
LEU A 147
 None
 0.78A 1v8bB-1ik6A:
undetectable		 1v8bB-1ik6A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  67
GLY A  69
PRO A  81
VAL A  29
ILE A  58
 None
 0.90A 2o4sA-1ik6A:
undetectable		 2o4sA-1ik6A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		4 / 7 GLY A  69
GLY A  65
THR A  60
ALA A  71
 None
 0.78A 3fpjB-1ik6A:
2.9		 3fpjB-1ik6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 11 ILE A  67
GLY A  69
PRO A  81
VAL A  29
ILE A  58
 None
 1.03A 3lzvB-1ik6A:
undetectable		 3lzvB-1ik6A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  67
GLY A  69
PRO A  81
VAL A  29
ILE A  58
 None
 0.97A 3nu3A-1ik6A:
undetectable		 3nu3A-1ik6A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 10 ILE A  67
GLY A  69
PRO A  81
VAL A  29
ILE A  58
 None
 0.99A 3nujA-1ik6A:
undetectable		 3nujA-1ik6A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 9 ILE A  67
GLY A  69
PRO A  81
VAL A  29
ILE A  58
 None
 0.95A 3nuoA-1ik6A:
undetectable		 3nuoA-1ik6A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 10 ILE A  67
GLY A  69
PRO A  81
VAL A  29
ILE A  58
 None
 1.04A 3oxvB-1ik6A:
undetectable		 3oxvB-1ik6A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 11 ILE A  67
GLY A  69
PRO A  81
VAL A  29
ILE A  58
 None
 1.03A 3oxvD-1ik6A:
undetectable		 3oxvD-1ik6A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		3 / 3 HIS A  19
ARG A  51
GLU A  50
 None
 0.76A 3qf1A-1ik6A:
0.2		 3qf1A-1ik6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		4 / 7 VAL A 173
PHE A  87
LEU A  99
ILE A 140
 None
 0.93A 3rfmA-1ik6A:
undetectable		 3rfmA-1ik6A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		4 / 5 ALA A  95
ILE A  85
LEU A  68
LYS A  93
 None
 1.19A 4g19A-1ik6A:
0.0		 4g19A-1ik6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 LEU A  18
GLU A 176
ASN A   9
ALA A 158
ASN A 157
 None
 1.34A 4pclB-1ik6A:
2.7		 4pclB-1ik6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		3 / 3 VAL A 218
LEU A 222
VAL A 234
 None
 0.44A 4wq4A-1ik6A:
undetectable		 4wq4A-1ik6A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 GLY A  69
ALA A  71
GLU A  97
GLU A  64
THR A  60
 None
 1.32A 4xt8A-1ik6A:
undetectable		 4xt8A-1ik6A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 9 ILE A  67
GLY A  69
PRO A  81
VAL A  29
ILE A  58
 None
 1.04A 5kr0A-1ik6A:
undetectable		 5kr0A-1ik6A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 ALA A 158
VAL A 218
VAL A 195
ASP A 236
ALA A 203
 None
 1.09A 5xxiA-1ik6A:
0.0		 5xxiA-1ik6A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 10 ILE A  67
GLY A  69
PRO A  81
VAL A  29
ILE A  58
 None
 0.97A 6dj2A-1ik6A:
undetectable		 6dj2A-1ik6A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		3 / 3 VAL A 274
GLU A 273
ILE A 260
 None
 0.66A 6f7lB-1ik6A:
undetectable		 6f7lB-1ik6A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1ik6 PYRUVATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		4 / 5 LEU A 237
TYR A 214
ILE A 317
GLY A 271
 None
 0.64A 6hd6A-1ik6A:
undetectable		 6hd6A-1ik6A:
11.57