SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1iko EPHRIN-B2
(Mus
musculus) 		4 / 5 ILE P 115
ILE P  94
ILE P 163
MET P 165
 None
 0.87A 1zgyA-1ikoP:
undetectable		 1zgyA-1ikoP:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1iko EPHRIN-B2
(Mus
musculus) 		4 / 8 ILE P  31
LEU P  33
VAL P 167
GLY P 168
 None
 0.81A 3w1wA-1ikoP:
undetectable		 3w1wA-1ikoP:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1iko EPHRIN-B2
(Mus
musculus) 		3 / 3 LEU P  33
ASP P  62
ILE P  57
 None
 0.67A 4xi3D-1ikoP:
undetectable		 4xi3D-1ikoP:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 1iko EPHRIN-B2
(Mus
musculus) 		5 / 11 LEU P  61
LEU P 101
LEU P 102
MET P 165
LEU P 127
 None
 1.32A 4zn7B-1ikoP:
undetectable		 4zn7B-1ikoP:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1iko EPHRIN-B2
(Mus
musculus) 		3 / 3 TYR P  76
LEU P 145
ASP P 149
 None
 0.86A 5zv2B-1ikoP:
undetectable		 5zv2B-1ikoP:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1iko EPHRIN-B2
(Mus
musculus) 		3 / 3 LEU P  61
ASN P  39
LEU P 102
 None
NAG  P   1 (-1.8A)
None
 0.45A 6exiA-1ikoP:
undetectable		 6exiA-1ikoP:
15.76