SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ikt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1ikt ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Homo
sapiens) 		4 / 6 ILE A  72
TRP A  36
PHE A  12
GLU A  35
 None
 1.43A 1nsiA-1iktA:
0.0
1nsiB-1iktA:
0.0		 1nsiA-1iktA:
14.83
1nsiB-1iktA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1ikt ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Homo
sapiens) 		4 / 6 TRP A  36
PHE A  12
GLU A  35
ILE A  72
 None
 1.40A 1nsiA-1iktA:
0.0
1nsiB-1iktA:
0.0		 1nsiA-1iktA:
14.83
1nsiB-1iktA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1ikt ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Homo
sapiens) 		4 / 7 ILE A  72
TRP A  36
PHE A  12
GLU A  35
 None
 1.45A 2nsiC-1iktA:
0.0
2nsiD-1iktA:
0.0		 2nsiC-1iktA:
14.83
2nsiD-1iktA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1ikt ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Homo
sapiens) 		4 / 7 ILE A  72
TRP A  36
PHE A  12
GLU A  35
 None
 1.40A 3e7gA-1iktA:
0.0
3e7gB-1iktA:
0.0		 3e7gA-1iktA:
15.67
3e7gB-1iktA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1ikt ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Homo
sapiens) 		4 / 7 TRP A  36
PHE A  12
GLU A  35
ILE A  72
 None
 1.41A 3e7gA-1iktA:
0.0
3e7gB-1iktA:
0.0		 3e7gA-1iktA:
15.67
3e7gB-1iktA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1ikt ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Homo
sapiens) 		4 / 8 TRP A  36
PHE A  12
GLU A  35
ILE A  72
 None
 1.44A 3e7gC-1iktA:
undetectable
3e7gD-1iktA:
0.0		 3e7gC-1iktA:
15.67
3e7gD-1iktA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ikt ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Homo
sapiens) 		4 / 7 ILE A  44
PHE A  12
PHE A  79
GLY A  41
 None
None
OXN  A 123 ( 4.4A)
None
 0.70A 3em0B-1iktA:
0.1		 3em0B-1iktA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ikt ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Homo
sapiens) 		4 / 7 ILE A  44
PHE A  12
PHE A  79
GLY A  42
 None
None
OXN  A 123 ( 4.4A)
None
 1.10A 3em0B-1iktA:
0.1		 3em0B-1iktA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1ikt ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Homo
sapiens) 		5 / 12 THR A  70
THR A  71
HIS A  37
LEU A 110
VAL A  30
 None
None
None
OXN  A 123 ( 4.9A)
None
 1.14A 3sp9A-1iktA:
undetectable		 3sp9A-1iktA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1ikt ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Homo
sapiens) 		5 / 12 THR A  70
THR A  71
HIS A  37
LEU A 110
VAL A  30
 None
None
None
OXN  A 123 ( 4.9A)
None
 1.17A 3sp9B-1iktA:
0.0		 3sp9B-1iktA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1ikt ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Homo
sapiens) 		4 / 7 TRP A  36
PHE A  12
GLU A  35
ILE A  72
 None
 1.49A 4cx7C-1iktA:
0.0
4cx7D-1iktA:
0.0		 4cx7C-1iktA:
14.83
4cx7D-1iktA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1ikt ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Homo
sapiens) 		4 / 7 ILE A  72
TRP A  36
PHE A  12
GLU A  35
 None
 1.44A 4nosC-1iktA:
0.0
4nosD-1iktA:
0.0		 4nosC-1iktA:
15.67
4nosD-1iktA:
15.67