SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1im4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 1im4 DBH
(Sulfolobus
solfataricus) 		5 / 12 GLY A 165
GLY A 144
ILE A 167
ALA A 146
SER A 159
 None
 1.15A 1ri4A-1im4A:
undetectable		 1ri4A-1im4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1im4 DBH
(Sulfolobus
solfataricus) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 SO4  A2002 ( 4.7A)
None
SO4  A2002 (-3.5A)
 0.71A 1w2zA-1im4A:
undetectable		 1w2zA-1im4A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 1im4 DBH
(Sulfolobus
solfataricus) 		3 / 3 LEU A 198
ARG A 194
ILE A 200
 None
 0.39A 2xn5B-1im4A:
0.0		 2xn5B-1im4A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 1im4 DBH
(Sulfolobus
solfataricus) 		5 / 10 LEU A 109
VAL A 145
ILE A 123
VAL A   6
ILE A   4
 None
 0.99A 3em3B-1im4A:
undetectable		 3em3B-1im4A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 1im4 DBH
(Sulfolobus
solfataricus) 		5 / 12 GLY A 144
GLY A 165
VAL A 166
MET A  89
ILE A 123
 None
 1.28A 3h52B-1im4A:
undetectable		 3h52B-1im4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1im4 DBH
(Sulfolobus
solfataricus) 		3 / 3 HIS A   1
HIS A  -3
HIS A   0
 None
SO4  A2002 ( 4.7A)
SO4  A2002 (-3.5A)
 0.84A 3mihA-1im4A:
0.0		 3mihA-1im4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1im4 DBH
(Sulfolobus
solfataricus) 		5 / 7 PRO A 185
LEU A 179
LEU A 176
ASN A 148
ILE A 150
 None
 1.31A 3u5jA-1im4A:
undetectable		 3u5jA-1im4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1im4 DBH
(Sulfolobus
solfataricus) 		5 / 8 PRO A 185
LEU A 179
LEU A 176
ASN A 148
ILE A 150
 None
 1.37A 3u5kA-1im4A:
undetectable		 3u5kA-1im4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1im4 DBH
(Sulfolobus
solfataricus) 		4 / 7 ARG A 127
ALA A 126
ILE A 123
GLY A 165
 None
 0.97A 3v4tH-1im4A:
undetectable		 3v4tH-1im4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1im4 DBH
(Sulfolobus
solfataricus) 		5 / 9 PRO A 185
LEU A 179
LEU A 176
ASN A 148
ILE A 150
 None
 1.30A 4c66A-1im4A:
undetectable		 4c66A-1im4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 1im4 DBH
(Sulfolobus
solfataricus) 		4 / 7 THR A 142
ASP A   7
ASP A   9
TYR A  48
 None
SO4  A2001 ( 4.3A)
SO4  A2001 (-4.9A)
None
 0.97A 5hwaA-1im4A:
undetectable		 5hwaA-1im4A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1im4 DBH
(Sulfolobus
solfataricus) 		5 / 8 PRO A 185
LEU A 179
LEU A 176
ASN A 148
ILE A 150
 None
 1.25A 5y1yA-1im4A:
undetectable		 5y1yA-1im4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 1im4 DBH
(Sulfolobus
solfataricus) 		5 / 11 GLU A 120
GLY A 144
ALA A 146
PRO A 147
ILE A 167
 None
 1.01A 5yk2A-1im4A:
0.2		 5yk2A-1im4A:
19.43